2009 Pharmacology and Therapeutics Publications

Abedin SA, Thorne J, Battaglia S, Maguire O, Hornung L, Doherty AP, Mills IG, Campbell MJ. Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells Carcinogenesis 2009; 30:449-456.

Adjei AA, Mandrekar SJ, Dy GK, Molina JR, Adjei AA, Gandara D, Ziegler KL, Stella PJ, Rowland Jr. KM, Schild SE, Zinner R. A phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small cell lung cancer (NSCLC): An NCCTG and SWOG study. J Clinical Oncology, 2009 [E-pub ahead of print].

Beerman TA, Gawron L, Shin S, Shen B, McHugh M. C-1027, a radiomimetic enediyne anti-cancer drug, preferrentially targets hypoxic cells. Cancer Res 2009; 69:593-598.       

Bistulfi G, Diegelman P, Foster BA, Kramer DL, Porter CW, Smiraglia DJ. Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools. FASEB J, 2009; 23:2888-2897.

Campbell MJ. Myeloid differentiation continues to reveal the complexity of nuclear receptor signaling. Cell Cycle 2009; 8:675.

Choi J-Y, James SR, Link PA, McCann SE, Hong C-C, Davis W, Nesline MK, Ambrosone CB, Karpf AR. Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis 2009;30:1889-1897. (PMID: 19584139)

Chung I, Han G, Seshadri M, Gillard B, Yu W-D, Foster BA, Trump DL, Johnson CS. Role of VDR in Anti-proliferative Effects of Calcitriol in Tumor-Derived Endothelial Cells and Tumor Angiogenesis in vivo. Cancer Research 2009; 69:967-975.

den Hollander A, McGee TL, Ziviello C, Banfi S, Dryja TP, Gonzalez-Fernandez F, Ghosh D, Berson E. A homozygous missense mutation in the IRBP gene (RBP3) associated with autosomal recessive retinitis pigmentosa. Invest Ophthalmol Vis Sci 2009; 50:1864-1872.

Fakih MG, Trump DL, Johnson CS, Tian L, Muindi J, Sunga AY. Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer. Int J Colorectal Disease 2009; 24:219-224.

Ghosh D, Griswold J, Erman M, Pangborn W. Structural Basis for Androgen Specificity and Oestrogen Synthesis in Human Aromatase. Nature 2009; 457:219-223.

Ghosh D, Griswold J, Erman M, Pangborn W. X-ray Structure of Human Aromatase Reveals An Androgen-Specific Active Site. J Steroid Biochem Mol Biol, 2009 Oct 4 [Epub ahead of print]. 

Gonzalez-Fernandez F, Bevilacqua T, Lee K, Chandrashekhar R, Hsu L, Garlipp MA, Griswold JB, Crouch R, Ghosh D. Retinol-binding site in interphotoreceptor retinoid-binding protein (IRBP): a novel hydrophobic cavity. Invest Ophthalmol & Vis Sci 2009; 50:5577-5586. 

Hildebrandt M, Adjei A, Weinshilboum R, Johnson JA, Berlin DS, Klein TE, Altman RB. Very important pharmacogene summary: sulfotransferase 1A1. Pharmacogenet Genomics 2009; 19:404-406.

Hsu Y-C, Meng X, Ou L, Ip MM. Activation of the AMP-activated protein kinase – p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells Cellular Signalling, (In Press) doi:10.1016/j.cellsig.2009.11.011.

Jeter CR, Badeaux M, Choy G, Chandra D, Patrawala L, Liu C, Calhoun-Davis C, Zaehres H, Daley GQ, Tang DG. Functional evidence that the self-renewal gene NANOG regulates human tumor development (p N/A). Stem Cells 2009; 27:993-1005.

Karpf AR, Bai S, James SR, Mohler JL, Wilson EM. Promoter DNA hypomethylation and cyclic AMP regulation of androgen receptor coregulator MAGE-11 in prostate cancer. Molecular Cancer Research 2009;7:523-535.

Khoury T, Alrawi S, Ramnath N, Li Q, Grimm M, Black J, Tan D. Eukaryotic initiation factor-4E (eIF4E) and cyclin D1 expression associated with patient survival in lung cancer. Clinical Lung Cancer 2009; 10:58-66.

Li F. Every single cell clones from cancer cell lines growing tumors in vivo may not invalidate the cancer stem cell concept. Mol Cells 2009; 27:491-492.

Li F, Cheng Q, Ling X, Stablewski A, Tang L, Foster BA, Johnson CS, Rustum YM, Porter CW. Generation of a novel transgenic mouse model: Evidence for its versatile applications in research and drug development. Am J Pathology, (In press).

Ling X, He X, Apontes P, Cao F, Azrak RG, Li F. Enhancing effectiveness of the MDR-sensitive compound T138067 using advanced treatment with negative modulators of the drug-resistant protein survivin. Am J Translational Res 2009; 1:393-405.

Link PA, Gangisetty O, James SR, Woloszynska-Read A, Tachibana M, Shinkai Y, Karpf AR. Distinct roles for histone methyltransferases G9a and GLP in cancer germline antigen gene regulation in human cancer cells and     murine ES cells. Molecular Cancer Research 2009; 7:851-862.

Liu W, Ip MM, Podgorsak MB, Das GM. Disruption of estrogen receptor alpha- p53 interaction in breast tumors: A novel mechanism underlying the anti-tumor effect of radiation therapy. Breast Cancer Research and Treatment 2009; 115:43-50.

Mathew G, Timm EA, Sotomayor P, Godoy A, Montecinos VP, Smith GJ, Huss WJ. ABCG2-Mediated DyeCycle Violet Efflux Defined Side Population in Benign and Malignant Prostate. Cell Cycle 2009; 8:1053-1061.

Mavis CK, Morey Kinney SR, Foster BA, Karpf AR. Expression level and DNA methylation status of Glutathione S-transferase genes in normal murine prostate and TRAMP tumors. The Prostate 2009; 69:1312-1324.

McGuire JJ, Bartley DM, Tomsho JW, Haile WH, Coward JK. Inhibition of human folylpolyglutamate  synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate. Arch Biochem Biophys 2009; 488:140-145.

McGuire JJ, Haile WH. Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-Amino-4-deoxy-5,8,10-trideazapteroyl-D,L-4’-methyleneglutamic acid (CH-1504) and its analogs. Biochem Pharmacol 2009; 77:1161-1172.

McHugh MM, Beerman TA. An extraction-free method by which a single slot blot can be used to quantify intracellular DNA damage (crosslinks or strand breaks) and changes in replication or DNA damage response proteins. BioTechniques 2009; 46:126-129.

Mihich E.  Twentieth Annual Pezcoller Symposium: Molecular Biology of Cancer -- 20 Years of progress punctuated by the Pezcoller Symposia. Cancer Research 2009; 69:407-410.

Morey Kinney SR, Zhang W, Gillard B, Karasik E, Moser MT, Foster BA, Karpf AR. Lack of evidence for green tea polyphenols as DNA methylation inhibitors in murine prostate. Cancer Prevention Research 2009; 2:1065-1075.

Morrison CD, Cheney RT, Johnson CS, Smith GJ, Mohler JL. Central Quadrant Procurement of Radical Prostatectomy Specimens. Prostate 2009; 69:770-773.

Muindi JR, Johnson CS, Trump DL, Christy R, Engler KL, Fakih MG. A phase I and pharmacokinetics study of intravenous calcitriol in combination with oral dexamethasone and gefitinib in patients with advanced solid tumors. Cancer Chemother Pharmacol 2009; 65:33-40.

Oliver CM, Schaefer AL, Greenberg EP, Sufrin JR. Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas aeruginosa. J Med Chem 2009; 52:1569-1575.

Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, Janssen K-P, Robine S, Velcich A, Augenlicht LH, Black AR, Black JD. Protein kinase C α tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res 2009; 315:1415-1428.

Rai K, Jaffri I, Chidester S, James SR, Karpf AR, Cairns BR, Jones DA. Dnmt3 and G9a cooperate for tissue-specific development in zebrafish. J Biol Chem, 2009 Nov 29 (Epub ahead of print). (PMID 19946145).

Rassnick KM, Muindi JR, Johnson CS, Bailey DB, Balkman CE, Page RL, Trump DL. Oral bioavailability of DN101, a concentrated formulation of calcitriol, after administration of a single dose to tumor-bearing dogs. Cancer Chemother Pharmacol, (In press).

Shah DK, Shin BS, Veith J, Toth K, Bernacki RJ, Balthasar JP. Use of an anti-vascular endothelial growth factor antibody in a pharmacokinetic strategy to increase the efficacy of intraperitoneal chemotherapy. J Pharmacol Exp Ther 2009; 329:580-591.

Sotomayor P, Godoy A, Smith GJ, Huss WJ. Oct4A is Expressed by a Subpopulation of Prostate Neuroendocrine Cells. The Prostate 2009; 69:401-410.

Starlard-Davenport A, Tryndyak VP, James SR, Karpf AR, Latendresse JR, Beland FA, Pogribny IP. Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats. Carcinogenesis Advance Access, 2009 December 14 [Epub ahead of print] (PMID: 20008439).

Sufrin JR, Finckbeiner S, Oliver CM. Marine-derived metabolites of S-adenosylmethionine as templates for new anti-infectives. Marine Drugs 2009; 7:401-434.

Thorne J, Campbell MJ, Turner BM. Transcription factors, chromatin and cancer. Intl J Biochemistry and Cell Biology 2009; 41:164-175.

Trump DL, Chadha M, Sunga AY, Fakih MG, Ashraf U, Silliman CG, Hollis BW, Nesline MK, Tian L, Tan W, Johnson CS. Vitamin D Deficiency and Insufficiency among Patients with Prostate Cancer. British J Urol, 2009 Apr 4, [Epub ahead of print] PMID 19426195.

Wang X, Chinnam M, Wang J, Wang YP, Zhang X, Marcon E, Moens P, Goodrich DW. Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse. Mol Cell Biol 2009;29:2794-2803.

Warren MA, Shoemaker SF, Shealy DJ, Bshar W, Ip MM. TNF deficiency inhibits mammary tumorigenesis and a TNF neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice. Molecular Cancer Therapeutics 2009; 8:2655-2663.

Xiao H, Zhang X, Goodrich DW. Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse. Genesis, (In press).

Zahedi K, Lentsch AB, Okaya T, Barone S, Sakai N, Witte DP, Arend LJ, Ahonen L, Jell J, Janne J, Porter CW, Soleimani M. Spermidine/spermine N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice. Am J Physiol Gastrointest Liver Physiol 2009; 296:G899-909.