Pharmacology and Therapeutics Publications


Adjei AA, Mandrekar SJ, Dy GK, Molina JR, Gandara DR, Ziegler KL, Stella PJ, Rowland KM, Jr., Schild SE, Zinner RG. Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. J Clin Oncol, 28:614-619, 2010.

Adjei AA, Salavaggione OE, Mandrekar SJ, Dy GK, Ziegler KL, Endo C, Molina JR, Schild SE, Adjei AA. Correlation between Polymorphisms of the Reduced Folate Carrier Gene (SLC19A1) and Survival after Pemetrexed-Based Therapy in Non-small Cell Lung Cancer (NSCLC): An NCCTG Based Study. J Thorac Oncol, 2010 Sep;5(9):1346-53. PMID: 20651609.

Adreeff M, Goodrich DW, Koeffler HP. Cell Proliferation and Differentiation.  In Cancer Medicine, eighth edition Hong, Bast, Hait, Kufe, Pollock, Weichselbaum, Holland, Frei eds PMPH-USA, Shelton, CT, 2010.

Akers SN, Odunsi K, Karpf AR. Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy. Future Oncol, 6:717-732, 2010. PMID: 20465387.

Battaglia S, Thorne J, Hornung LB, Doig CL, Liu S, Sucheston LE, Bianchi A, Khanim F, Gommersall LM, Coulter HSC, Rhaka S, Giddings I, Cooper C, McCabe CJ, Bunce CM, Campbell MJ. Elevated NCOR1 disrupts PPAR signaling in prostate cancer and forms a targetable epigenetic lesion. Carcinogenesis, 31:1650-1660, 2010. PMID: 20466759

Bhaskarla A, Tang P, Mashtare T, Demmy TL, Nwogu C, Adjei AA, Reid M, Yendamuri S. Synchronous non small cell cancers should not be classified as Stage IV - A Seer Database analysis. J Surg Res, 158:173, 2010.

Gangavarapu KJ, Huss WJ. Isolation and applications of prostate side population cells based on dye cycle violet efflux. Current Protocols in Toxicology, (In press).

Graham KA, Kulawiec M, Owens KM, Li X, Desouki MM, Chandra D, Singh KK. NADPH oxidase 4 is an oncoprotein localized to mitochondria.  Cancer Biol Ther, 10:223-231, 2010.

Hidalgo AA, Trump DL, Johnson CS. Glucocorticoid regulation of the vitamin D receptor. J Steroid Mol Biol, 121:372-375, 2010.   PMCID: PMC2907065

Jain RK, Trump DL, Egorin MJ, Fernandez M, Johnson CS, Ramanathan RK. A phase I study of the vitamin D3 analogue ILX23-7553 administered orally to patients with advanced solid tumors. Investigational New Drugs, 2010 July 26. [Epub ahead of print] PMID: 20661623.

Konduri S, Medisetty R, Liu W, Kaiparettu BA, Srivastava P, Brauch H, Fritz P, Swetzig WM, Gardner AE, Khan SA, Das GM. Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. Proc Natl Acad Sci (USA), 107:15081-15086, 2010.   PMID: 20696891

Lee X, Fox A, Sufrin JR, Hugues H, Majcherczyk P, Haas D, Reimman C. Identification of the biosynthetic gene cluster for the Pseudomonas aeruginosa antimetabolite L-2-Amino-4-methoxy-trans-3-butenoic acid. J Bacteriol, 192:4251-4255, 2010. PMID: 20543073.

Li F, Cheng Q, Ling X, Stablewski A, Tang L, Foster BA, Johnson CS, Rustum YM, Porter CW. Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers. Am J Pathol, 176:1629-1638, 2010.

Ling X, Calinski D, Chanan-Khan AA, Zhou M, Li F. Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types. J Exp Clin Cancer Res, 29:1-10, 2010. PMID: 20096120.

Luo W, Karpf AR, Deeb KK, Muindi J, Morrison CD, Johnson CS, Trump DL. Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 gene expression in human prostate cancer. Cancer Res, 70:5953-5962, 2010. PMID: 20587525.

Ma Y, Yu W-D, Trump DL, Johnson CS. 1,25D3 enhances antitumor activity of gemcitabine and cisplatin in human bladder cancer models. Cancer, 116:3294-3303, 2010. PMCID: PMC2891990.

Maguire O, Campbell MJ. Vitamin D and p53 – Differentiating their relationship in AML. Cancer Biol Ther, 10, 2010 Sep 8;10(5). [Epub ahead of print]. PMID: 20592491.

Mandrekar SJ, Qi Y, Hillman SL, Allen Ziegler KL, Reuter NF, Rowland KM, Jr., Kuross SA, Marks RS, Schild SE, Adjei AA. Endpoints in phase II trials for advanced non-small cell lung cancer. J Thorac Oncol, 5:3-9, 2010.

Morey Kinney SR, Moser MT, Pascual M, Greally JM, Foster BA, Karpf AR. Opposing roles of Dnmt1 in early and late stage murine prostate cancer.  Mol Cell Biol, 2010 Sep; 30(17): 4159-74. PMID: 20584988.

Muindi JR, Yu W-D, Ma Y, Engler KL, Kong R-X, Trump DL, Johnson CS. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology 2010 Jun 30. [Epub ahead of print] PMID: 20591973.

Rai K, Jafri IF, Chidester S, James SR, Karpf AR, Cairns BR, Jones DA. Dnmt3 and G9a Cooperate for Tissue-specific Development in Zebrafish. J Biol Chem, 285:4110-4121, 2010.

Ramakrishnan V, Timm M, Haug JL, Kimlinger TK, Wellik LE, Witzig TE, Rajkumar SV, Adjei AA, Kumar S. Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs. Oncogene, 29:1190-1199, 2010.

Starlard-Davenport A, Tryndyak VP, James SR, Karpf AR, Latendresse JR, Beland FA, Pogribny IP. Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats. Carcinogenesis, 31:376-381, 2010.

Watkins RJ, Read ML, Smith VE, Sharma N, Reynolds GM, Buckley L, Doig C, Campbell MJ, Lewy G, Eggo MC, Loubiere L, Franklyn JA, Boelaert K, McCabe CJ. Pituitary tumor transforming gene binding factor - a new gene in breast cancer. Cancer Res, 70:3739-3749, 2010. PMID: 20406982.

Woloszynska-Read A, James SR, Song C, Jin B, Odunsi K, Karpf AR. BORIS/CTCFL expression is insufficient for cancer-germline antigen gene expression and DNA hypomethylation in ovarian cell lines. Cancer Immunity, 10:6, 2010. PMCID: PMC2916237.

Xiao H, Zhang X, Goodrich DW. Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse. Genesis, 48:121-126, 2010.

Yu S, Khor TO, Cheung KL, Li W, Wu TY, Huang Y, Foster BA, Kan YW, AN K. Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PLoS One, 2010 Jan 5;5(1):e8579.

Yu W-D, Ma Y, Flynn G, Muindi J, Kong R-X, Trump DL, Johnson CS. Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system. Cell Cycle, 9:3022-3029, 2010. PMID: 20699664.