Genetics and Genomics

Program Leaders

John Krolewski, MD, PhD
Co-Leader
Genetics and Genomics CCSG Program
Erik Knudsen, PhD
Co-Leader
Genetics and Genomics CCSG Program

The Genetics and Genomics Program is committed to fostering intra- and inter-programmatic and collaborative innovative studies that focus on functional genomics. The overall goal of the Genetics and Genomics Program is to identify and characterize genetic and genomic changes that drive and/or predict cancer initiation, progression or therapeutic response, thus developing new therapeutic targets. Historically, much of the focus in this Program has been in basic research and discovery; more recently the goal has been broadened to encourage involvement by Program members in translational and clinical studies. The Program’s central themes are:

  1. Interrogating genetic drivers of tumor hallmarks
  2. Delineating epigenetic states as biomarkers and targets in cancer
  3. Translation of genetic and epigenetic discovery toward clinical application

The program is led by John Krolewski, MD, PhD and Erik Knudsen, PhD. The Genetics and Genomics Program has longstanding strength in basic cancer genetic discovery and functional genomics research. Innovative new projects are promoted by the establishment of cutting-edge genetic screening, sequencing and bioinformatics platforms, and by Genetics and Genomics-led projects that emphasize highly collaborative studies that will yield new grants and/or high-impact publications.

The Genetics and Genomics Program has 27 members with expertise in mouse models of cancer, molecular analysis of human cancer, genetics and pathways controlling metastasis, epigenomics, bioinformatics and molecular pathology, all of which are fully integrated into the themes within the Program. The Program members come from ten departments at Roswell Park.

Program Members

Andrei Bakin, PhD
Associate Professor of Oncology
Department of Cancer Genetics and Genomics
Bora Baysal, MD, PhD
Associate Professor of Oncology
Department of Pathology & Laboratory Medicine
Kevin Hasegawa Eng, PhD
Associate Professor of Oncology
Department of Biostatistics and Bioinformatics
Jia Fang, PhD
Associate Professor of Oncology
Pharmacology and Therapeutics
Thomas Furlani, PhD
Chief Information Officer
Information Technology
Irwin Gelman, PhD
Director
Research Integration
David Goodrich, PhD
Member
Genetics and Genomics CCSG Program
Kenneth Gross, PhD
Emeritus Faculty
Department of Molecular and Cellular Biology
Michael Higgins, PhD
Associate Professor of Oncology
Department of Molecular and Cellular Biology
Erik Kauffman, MD
Assistant Professor of Oncology
Department of Urology
Erik Knudsen, PhD
Co-Leader
Genetics and Genomics CCSG Program
John Krolewski, MD, PhD
Co-Leader
Genetics and Genomics CCSG Program
Charles LeVea, MD, PhD
Chair
Department of Pathology and Laboratory Medicine
Qiang John Li, MD, PhD
Assistant Professor of Oncology
Department of Urology
Song Liu, PhD
Director
Bioinformatics
Martin Morgan, PhD
Director
R/Bioconductor Project
Carl Morrison, MD, DVM
Senior Vice President
Scientific Development and Integrative Medicine
Kent Nastiuk, PhD
Assistant Professor of Oncology
Department of Cancer Genetics and Genomics
Joyce Ohm, PhD
Associate Professor of Oncology
Department of Cancer Genetics and Genomics
Nicoletta Sacchi, PhD
Professor of Oncology
Department of Cancer Genetics and Genomics
Santosh Patnaik, MD, PhD
Assistant Professor of Oncology
Department of Thoracic Surgery
Jianmin Wang, PhD
Co-Director
Bioinformatics Core Resource
Lei Wei, PhD
Co-Director
Bioinformatics Shared Resource
Agnieszka Witkiewicz, MD
Director
Center for Personalized Medicine
Anna Woloszynska, PhD
Assistant Professor of Oncology
Department of Pharmacology and Therapeutics
Bo Xu, MD, PhD
Associate Professor of Oncology
Department of Pathology & Laboratory Medicine
Edwin Yau, MD, PhD
Assistant Professor of Oncology
Department of Cancer Genetics & Genomics
Sai Yendamuri, MD, FACS
Chair
Department of Thoracic Surgery
Y. Eugene Yu, PhD
Professor of Oncology
Department of Cancer Genetics and Genomics
Jianmin Zhang, PhD
Associate Professor of Oncology
Department of Cancer Genetics and Genomics
Qianqian Zhu, PhD
Co-Director
Biostatistics and Statistical Genomics Division

Contact Person

Ellen Sanders-Noonan
Administrator
Tel: 716 845-8654
Fax: 716 845-1698
Ellen.Sanders@RoswellPark.org