John Krolewski, MD, PhD - Program Leader
Contact Person: Ellen Sanders-Noonan
Tel: 716 845-8654
Fax: 716 845-1698
The Genetics and Genomics Program is committed to fostering intra- and inter-programmatic and collaborative innovative studies that focus on functional genomics. The overall goal of the Genetics and Genomics Program is to identify and characterize genetic and genomic changes that drive and/or predict cancer initiation, progression or therapeutic response, thus developing new therapeutic targets. Historically, much of the focus in this Program has been in basic research and discovery; more recently the goal has been broadened to encourage involvement by Program members in translational and clinical studies. The Program’s central themes are:
1) Interrogating genetic drivers of tumor hallmarks
2) Delineating epigenetic states as biomarkers and targets in cancer
3) Translation of genetic and epigenetic discovery toward clinical application
The program is led by John Krolewski, MD, PhD and Erik Knudsen, PhD. The Genetics and Genomics Program has longstanding strength in basic cancer genetic discovery and functional genomics research. Innovative new projects are promoted by the establishment of cutting-edge genetic screening, sequencing and bioinformatics platforms, and by Genetics and Genomics-led projects that emphasize highly collaborative studies that will yield new grants and/or high-impact publications.
The Genetics and Genomics Program has 27 members with expertise in mouse models of cancer, molecular analysis of human cancer, genetics and pathways controlling metastasis, epigenomics, bioinformatics and molecular pathology, all of which are fully integrated into the themes within the Program. The Program members come from ten departments at Roswell Park.