Zoledronic Acid

Brand Names

Zometa, Reclast® (There may be other brand names for this medication.)

How is it Administered?

Your medicine will be given intravenously, which means it will be given by injection into a vein, usually in your arm, wrist, hand or chest.

What is Zoledronic Acid Used For?

This drug is used to treat high blood calcium levels (hypercalcemia) that sometimes occur in people that have cancer; osteoporosis; and bone damage caused by multiple myeloma or cancers that have spread to the bones. Zoledronic acid is used to treat bone disease It will not slow or stop the spread of cancer.

How Does it Work?

There are two kinds of bone cells – osteoblasts that create bone and osteoclasts that break down bone. The creation and destruction of bone is generally kept balanced, though we do tend to lose bone mass as we age.

Some cancers cause the osteoclasts to speed up their destruction of bone. In addition to bone weakness, which increases the risk of a fracture, this can also cause pain and excess calcium to be released into the bloodstream. Calcium can affect your heart rate, among other bodily functions.

Zoledronic acid is in a class of medications called bisphosphonates. It works by slowing bone breakdown by the osteoclasts, increasing bone density (thickness), and decreasing the amount of calcium released from the bones.

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