How is Sorafenib Administered?
Sorafenib comes as a 200 mg tablet, which is taken by mouth. The typical dose is (2) 200 mg tablets twice a day. Your doctor will determine the appropriate dose and schedule to treat your disease.
What is it Used For?
Sorafenib is approved by the FDA (Food and Drug Administration) to treat kidney and liver cancers. Sorafenib is also used to treat leukemia that has a mutation in a gene called FLT-3. This is an off-label use because sorafenib is approved for use against other cancers, not for acute myeloid leukemia (AML). The FDA allows doctors to use medications off label and it is a common practice when the cancer is hard to treat or has no standard therapy.
How Does it Work?
Sorafenib is a type of targeted therapy, rather than traditional chemotherapy. Specifically, it is a tyrosine kinase inhibitor (TKI).
Cancer is a group of diseases in which abnormal cells multiply without control. Traditional chemotherapy agents identify cancer cells by their rapid rate of multiplication– and then attack those cells. Unfortunately, it also attacks normal cells that multiply quickly. Targeted therapy identifies other differences between normal cells and cancer cells, and then uses that difference to attack the cancer cells, sparing the normal cells.
Sorafenib works by blocking the action of the abnormal FLT-3 gene that signals leukemia cells to multiply.