Pemetrexed

Brand Names

Alimta® (There may be other brand names for this medication.)

How is Pemetrexed Administered?

Your medicine will be injected into a vein.

What is it Used For?

This drug is used to treat mesothelioma, a rare cancer of the membrane that covers most of the internal organs, and small-cell lung cancer.

How Does it Work?

Cancer is a group of diseases in which abnormal cells divide without control. Both normal and cancer cells go through cycles that include a resting phase, active growing phases, and division. Your chemotherapy schedule is based upon the type of cancer you have, the rate at which they divide, and the times when each drug is the most likely to be effective. This is why chemotherapy is typically given in cycles.

Pemetrexed is iin a class of drugs known as antimetabolites, drugs that interrupt the cell cycle. It is biologically similar to a substance normally found in the cell. The cancer cells take in the pemetrexed and it disrupts their growth and their ability to reproduce. If the cells are unable to divide, they die.

The faster cells are dividing (reproducing), the more likely it is that chemotherapy will damage/kill the cells. Unfortunately, chemotherapy does not know the difference between cancer cells and normal cells that reproduce frequently. The cells in your body that are the most likely to be affected by chemotherapy are the cells that line the digestive tract (mouth, stomach, intestines), hair follicles, and blood cells.

These normal cells will eventually grow back and be healthy. During treatment, however, you may experience side effects from the chemotherapy’s effects on these normally fast reproducing cells including nausea, vomiting, diarrhea, mouth sores, hair loss, and decreased blood counts. Low blood counts may cause fatigue, anemia, and a significant decrease in your ability to fight off infections.

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