Brand Names

Zofran®, Zofran® ODT, Zuplenz® (There may be other brand names for this medication.)

How is Ondansetron Given?

Ondansetron may be injected just under the skin (subcutaneous injection), usually in the abdomen. Ondansetron is also available to take by mouth as a tablet, a rapidly dissolving tablet, or a liquid. The first dose is usually given 30 minutes before starting chemotherapy, one to two hours before starting radiation therapy, or one hour before surgery.

What Is It Used For?

Ondansetron prevents nausea and vomiting caused by chemotherapy, radiation therapy, or surgery.

How Does it Work?

Ondansetron is in a class of medications called 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

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