Press Releases

Metastasis, or the spread of cancer from one site in the body to another, remains a leading cause of cancer-related deaths. Understanding how solid tumors spread is crucial to the effort to improve patient outcomes. A team of scientists led by Scott Abrams, PhD, at Roswell Park Comprehensive Cancer Center uncovered a pathway associated with metastases to the lung, a common site for cancer spread. The work, just published in the journal JCI Insight, has potentially significant implications that may point the way to new cancer therapies.

Approximately one-third of patients with non-small-cell lung cancer (NSCLC) who were treated with the targeted therapy sotorasib (brand name Lumakras) survived for at least two years after enrolling in a large clinical trial that evaluated the drug — significantly longer than what can be expected from patients treated with standard chemotherapy.

Little is known about how radiation therapy to kill cancer cells affects immune cells and other components of patient tumors. But a study out of Roswell Park Comprehensive Cancer Center is shedding light on that process, providing information that could be key for planning treatment regimens that combine immunotherapy and radiation therapy. The authors outline their findings in a new study in the Journal for ImmunoTherapy of Cancer.

A new approach to CAR T therapy has shown great promise against small cell lung cancer in a preclinical study. The findings cover new ground in our understanding of how CAR T can be employed against solid-tumor cancers, and provide support for further studies in cancer patients.

As the legalization of medicinal and recreational cannabis becomes more common in localities across the country, so does research on its use and effects. Results of an anonymous cancer patient and survivor survey conducted by a team from Roswell Park Comprehensive Cancer Center’s Center for Translational Research on Cannabis and Cancer (CTRCC) will be shared at the American Association for Cancer Research 2023 Annual Meeting in Orlando.

A recent research effort led by Sarbajit Mukherjee, MD, MS, Assistant Professor of Oncology at Roswell Park Comprehensive Cancer Center, demonstrated that a new chemotherapy combination — trifluridine/tipiracil (FTD/TPI) and oxaliplatin — is well tolerated and has activity among patients with esophageal cancer.

A large retrospective study conducted by physician researchers from Roswell Park Comprehensive Cancer Center reports benefits of chemotherapy for many patients with early-stage breast cancer with rare variant histology, or tumor anatomy. These findings will be presented by first author Arya Mariam Roy, MBBS, during the American Association for Cancer Research (AACR) annual meeting, continuing through April 19 in Orlando, Florida.

Research from Roswell Park Comprehensive Cancer Center shows that following the National Comprehensive Cancer Network (NCCN) clinical practice guidelines for the diagnosis and treatment of cancer results in better outcomes for patients — but adherence to the guidelines depends on where the patient is diagnosed and treated and what type of cancer is involved.

Roswell Park Comprehensive Cancer Center physician-scientists and researchers will present new research on emerging treatment options and population health at the 2023 annual meeting of the American Association for Cancer Research, taking place in Orlando, Florida, from April 14-19.