Dr. Chernov joined the staff of Roswell Park Comprehensive Cancer Center (Roswell Park) in July of 2007, as a Director of Small Molecule Screening Core Facility in the Department of Cell Stress biology.
Dr. Chernov earned an MS degree in Biochemistry and Physiology from Moscow State University (Moscow Russia) and his Ph.D. in Biochemistry in 1987 from the Cancer Research Center (Moscow Russia).
Dr. Chernov has authored or co-authored more than 30 journal publications, and abstracts.
Dr. Chernov's research interest focuses on the study of regulation and function of p53 tumor suppressor and development and utilization of cell based readout systems for drug discovery.
Regulation of p53 tumor suppressor, modulation of p53 activity by small molecules
Development and utilization of cell based assays for high throughput chemical screenings
Antoch MP, Chernov MV. Pharmacological modulators of the circadian clock as potential therapeutic drugs. Mutation research. Genetic toxicology and environmental mutagenesis 2009; 680(1-2):109-115
Hu Y, Spengler ML, Kuropatwinski KK, Comas-Soberats M, Jackson M, Chernov MV, Gleiberman AS, Fedtsova N, Rustum YM, Gudkov AV, Antoch MP, Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1. Oncotarget 2011; 2(12):1279-1290
Jegede O, Khodyakova A, Chernov M, Weber J, Menendez-Arias L, Gudkov A, Quinones-Mateu ME. Identification of low molecular weight inhibitors of HIV 1 reverse transcriptase using a cell based high throughput screening system. Antiviral research 2011; 91(2):94-98
Saha S, Wang J, Buckley B, Wang Q, Lilly B, Chernov M, Kashina A. Small molecule inhibitors of arginyltransferase regulate arginylation dependent protein degradation cell motility and angiogenesis. Biochemical pharmacology 2012; 83 (7):866-873
Luo W, Karpf AR, Chernov M, Johnson C, Trump D. Protein kinase CK2 contributes to 1, 25-dihydroxyvitamin D3-mediated CYP24A1 gene expression in prostate cancer cells. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #942