Over the past 30 years, I have focused my clinical research in expanding our understanding of the immunobiology of human cancer and the development of new immune therapies. Our NCI funded clinical trials were aimed at minimizing regulatory and suppressive pathways and enhancing existent tumor-specific immune function.
I did my cancer immunology and immunotherapy training with John M. Kirkwood while at Yale University. I continued to develop my experience and qualifications as a translational immunotherapy clinical scientist while at Yale and the University of Pittsburgh and Pittsburgh Cancer Institute. I was a cadre member of the both CALGB and ECOG melanoma programs and am currently a member of the Alliance Experimental Therapeutics Program.
I am currently the Geisel PI on the Cancer Immunotherapy Trial Network and on the executive council of the Cytokine Working Group. I have published over 200 original research manuscripts in the areas of renal cell cancer, melanoma and immune therapy strategies including cytokine therapies, dendritic cell vaccines, immune checkpoint inhibition, targeted therapies and ex vivo expanded effector cells for adoptive transfer. My laboratory has developed phenotypic, functional and molecular assays which enable us to explore the immune response to disease and therapy. While at the University of Pittsburgh and the Pittsburgh Cancer Institute, I was the Director of the Hematology/Oncology Fellowship Program and PI on a T32 Training award from the NCI.
Over the years, I have successfully mentored five medical students, ten residents, 39 postdoctoral/fellows, and 18 junior faculty. I was Staff Physician at the Taussig Cancer Institute, Cleveland Clinic Foundation and Director of the Melanoma Program and Professor in the Cleveland Clinic Lerner School of Medicine. In 2016, I assumed the role of Professor and Chair, Department of Medicine, Senior Vice President for Clinical Investigation, The Katherine Anne Gioia Chair of Medicine, Roswell Park Cancer Institute and Professor and Chief of the Section of Oncology at the University of Buffalo.