John M. Kane III, MD, FACS

John M. Kane III, MD, FACS

Professor of Oncology
Chair, Surgical Oncology
Chief, Melanoma/Sarcoma Service, Department of Surgical Oncology
Program Director, Surgical Oncology Fellowship
Roswell Park Comprehensive Cancer Center
Associate Professor of Surgery
Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
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Areas of Expertise: 
Surgical oncology
Soft tissue sarcomas at all anatomic locations: extremity, truncal, intra-abdominal/retroperitoneal, head and neck and gastrointestinal stromal tumors (GIST)
Rare soft tissue and skin tumors
Merkel cell carcinoma
Cytoreductive/Hyperthermic Intraperitoneal Chemotheraphy (HIPEC)
Carcinomatosis, primary peritoneal mesothelioma
Isolated regional therapy (Isolated limb perfusion (ILP) and isolated limb infusion (ILI))
Special Interests: 
Development of a novel fully recombinant heat shock protein-gp100 melanoma vaccine for a phase I clinical trial
Correlation of soft tissue sarcoma tissue microarray biomarker expression with patient outcome
Use of pre-clinical models to examine novel/combination therapies for isolated regional therapy and soft tissue sarcomas


I am an Associate Professor of Surgery and Chief of the Melanoma/Sarcoma service at Roswell Park Comprehensive Cancer Center. My interest in melanoma, sarcoma, and regional therapies dates back to the beginning of my practice in the year 2000. I am the main sarcoma surgeon at Roswell Park and treat soft tissue sarcomas at all anatomic locations; extremity, truncal, intra-abdominal/retroperitoneal, head and neck, and gastrointestinal stromal tumors (GIST). I am a member of major sarcoma groups including the NCCN Sarcoma Panel, the Connective Tissue Oncology Society, and the Radiation Therapy Oncology Group (RTOG) Sarcoma Committee. I have been the lead investigator for several sarcoma trials at Roswell Park, have authored multiple papers on the treatment of soft tissue sarcomas, and have been an invited speaker on this topic at national meetings. I oversee our weekly sarcoma/soft tissue tumor multidisciplinary conference where all new sarcoma and rare soft tissue tumor cases are discussed in order to develop the optimal treatment plan.

I also treat unusual benign and locally aggressive soft tissue tumors. These include desmoid/aggressive fibromatosis, dermatofibrosarcoma protuberans (DFSP), neurogenic tumors such as neurofibroma and schwannoma, large and atypical intramuscular lipomatous tumors, solitary fibrous tumor, ganglioneuroma, and adrenal myelolipoma. As noted above, our weekly multidisciplinary conference allows for a thorough discussion of the patients with these various tumors. In some cases, surgery may not even be necessary.

I have a significant clinical interest in melanoma and other aggressive cutaneous malignancies such as Merkel cell carcinoma. Our Institution has been offering sentinel lymph node biopsy since 1996 and I have personally performed over 450. For patients with nodal metastatic disease, I frequently perform axillary dissections (very different from what is done for breast cancer), superficial and deep groin dissections, and even less common lymphadenectomies in the epitrochlear and popliteal basins. I have advanced the regional therapies program at Roswell for patients with isolated extremity disease (in transit melanoma, Merkel cell carcinoma, and some sarcomas) that is no longer amenable to simple surgical excision. Isolated limb perfusion (ILP) or isolated limb infusion (ILI) can still be potentially curative in these situations. Roswell Park Comprehensive Cancer Center is one of only two institutions in New York State that performs these isolated regional therapies.

As another type of isolated regional therapy, I developed the cytoreduction/hyperthermic intraperitoneal chemoperfusion (HIPEC) program at Roswell Park Comprehensive Cancer Center in 2002. I routinely perform cytoreductive surgery/HIPEC for appendiceal neoplasms, colorectal cancer, mesothelioma, and other peritoneal surface malignancies. In addition to patients with these diseases in WNY, I have provided this treatment option for the province of Ontario.

Aside from my clinical responsibilities, I serve as the Surgical Oncology Fellowship Program Director and on the Executive Council of the Society of Surgical Oncology. I am a fellow of the American College of Surgeons and a member of multiple surgical and oncologic societies, including the Society of Surgical Oncology, the American Society of Clinical Oncology, and the Association for Academic Surgeons. I have served as the past president for both the WNY Chapter of the American College of Surgeons and the Buffalo Surgical Society. I was also previously the WNY State Chair for the ACS Commission on Cancer.


Education and Training: 
MD - Johns Hopkins School of Medicine, Baltimore, MD
Resident - Department of Surgery - University of Pittsburgh, Pittsburgh, PA
Research Fellowship - Department of Surgery, University of Pittsburgh, Pittsburgh, PA
Clinical Fellow (SSO approved) - Department of Surgical Oncology - Roswell Park Cancer Institute, Buffalo, NY
Board Certification: 
American Board of Surgery
Professional Memberships: 
Association for Academic Surgery
Fellow-Society of Surgical Oncology
Western New York American College of Surgeons
Radiation Therapy Oncology Group
Buffalo Surgical Society
Connective Tissue Oncology Society
Association for Surgical Education
American Society of Clinical Oncology
American College of Surgeons
American College of Surgeons Oncology Group
Honors and Awards: 
2010 - University at Buffalo Department of Surgery, Third Year Resident's Best Educational Surgical Rotation
2009 - Roswell Park Golden Apple Award, for the most outstanding Surgical Oncology faculty educator
2006 - University at Buffalo School of Medicine Commendation for Teaching Excellence Award
2005 - Roswell Park Golden Apple Award, for the most outstanding Surgical Oncology faculty educator
2000 - Roswell Park Holyoke Award for the most outstanding Surgical Oncology fellow
1999 - Berlex Oncology Foundation Award recipient, Clinical Pharmacology of Anticancer Agents Workshop; Lansdowne, VA
1991 - Alpha Omega Alpha
1991 - Johns Hopkins School of Medicine, Hewlett-Packard Top Medical Graduate Award
1987 - Summa Cum Laude, Allegheny College
1986 - Phi Beta Kappa

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