Bonnie Hylander, PhD – Research Scientist
My primary focus in the lab is in developing our SCID mouse/ patient tumor xenograft program. This unique resource grows out of our being part of a Comprehensive Cancer Center and the desire of patients to help others by making tissue available for scientific research. By engrafting patient tumors into mice, we are able to create a clinically relevant model of human malignant disease that allows us to investigate the efficacy of novel therapeutics against actual patient tumors. Our goal is to understand the basis of sensitivity and resistance in order to inform future patient selection when these therapeutics reach the clinic. Since my PhD is in Anatomy, I have a particular interest in histological analyses of these specimens, including immunohistochemical analysis of tumor markers and signaling molecules. In particular, we are studying the mechanisms of sensitivity and resistance to Apo2L/TRAIL, a death inducing ligand that targets the apoptotic pathway in malignant cells.
Jeanne Prendergast – Lab Manager
I began working at Roswell Park as a Research Technologist and am now the Repasky Lab Manager. We always have a good mix of undergraduates, college students, Masters and PhD students, as well as PostDocs and Clinical Residents and Fellows. With the variety of people and projects, each day here is always fun and interesting.
Rose Pitoniak – Supervisor: SCID mouse colony
My background is in Nursing, and I was supervisor of the O.R. at Roswell Park Comprehensive Cancer Center for many years. Gradually, I developed an interest in Cancer Research and am now responsible for the day-to-day supervision of our SCID mouse/ patient tumor xenograft colony. In addition to carrying out experiments evaluating the anti-tumor potential of new therapeutics against these patient tumors, I help to teach these procedures to new technicians and students.
Diane Thompson - Project Coordinator
During the time I have worked at Roswell Park, I have been in several great labs. I am enjoying working in the Repasky lab coordinating special projects both in our lab and in the Immunology Department.
Katie Kokolus - Graduate Student
I was born and raised in Buffalo attending Nardin Academy for high school. I then moved to Pittsburgh and attended Duquesne University where I received by B.S in Biology and M.S. in Forensic Science and Law. As an avid Bills and Sabres fan I decided that 5 years in Pennsylvania was enough and moved back to Buffalo and entered the Immunology PhD program at Roswell Park. I am investigating how thermal stress impacts the anti-tumor immune response.
Recently Graduated PhD students:
2010: Melissa Grimm, PhD- now a Post Doc at Roswell Park Comprehensive Cancer Center, Dr. Brahm Segal’s lab
2010: Evan Zynda, PhD- now Post Doc at Roswell Park Comprehensive Cancer Center, Dr. Eugene Kandel’s lab
2011: Thomas Mace, PhD- Post Doc at The Ohio State University, Dr. Greg Lesinski’s lab
2012: Chen Ting (Kelly) Lee, PhD- now a Post Doc at Duke University, Dr. Mark Dewhirst’s lab
2012: Maegan Capitano, PhD- now a Post Doc at University of Indiana, Dr. Hal Broxmeyer’s lab