Dr. Zhang joined the Roswell Park faculty in 2016. He graduated from Chungbuk National University with a PhD degree in Molecular Embryology from one of the National research laboratories in South Korea. During his doctoral studies, he worked extensively on early embryo development and regulation of maternal gene expression, which led to 8 important publications (4 of which were first author papers) in the field. After finishing Ph.D studies, he did a short post-doctoral training at the University of Cincinnati College of Medicine, studying the role of MED1 and ARGLU1 in breast cancer, with a first author J. Biol. Chem. paper. He then joined MD Anderson Cancer Center as a postdoctoral fellow in February 2012. During his postdoctoral training at MDACC, he has published 8 papers (4 of which were first author papers). He was appointed to an Instructor position in 2015, and an Assistant Professor of Oncology in 2016. Currently, he is using genetic mouse models, cancer cell lines and xenografts, as well as human primary tumor samples to investigate the prostate development (epithelial biology) and prostate tumorigenesis and progression.
Zhang D*, Zhao S, Li X, Kirk JS, Tang DG. Prostate Luminal Progenitor Cells in Development and Cancer. Trends Cancer, 2018 Nov; 4(11):769-783.
Zhang D*, Tang DG. "Splice" a way towards neuroendocrine prostate cancer. EBioMedicine. 2018, pii: S2352-3964(18)30331-1.
Li Q, Deng Q, Chao HP, Liu X, Lu Y, Lin K, Liu B, Tang GW, Zhang D, Tracz A, Jeter C, Rycaj K, Calhoun-Davis T, Huang J, Rubin MA, Beltran H, Shen J, Chatta G, Puzanov I, Mohler JL, Wang J, Zhao R, Kirk J, Chen X, Tang DG*. Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nature Communications, 2018 Sep 6;9(1):3600.
Zhang D*., Tang DG., Rycaj K*. Cancer stem cells: Regulation programs, immunological properties and immunotherapy. Seminar in Cancer Biology. 2018, pii: S1044-579X(17)30280-8. (*Corresponding authors)
Zhang D*., Gong S., Lu Y., Jeter C., Tang DG*. Histone 2B-GFP Label-Retaining Prostate Luminal Cells Possess Progenitor Cell Properties and Are Intrinsically Resistant to Castration. Stem Cell Reports, 2018, 10(1):228–242. (*Corresponding authors) see Press Release
Liu C., Liu R., Zhang D., Deng Q., Liu B., Chao HP., Rycaj K., Takata Y., Lin K., Lu Y., Zhong Y., Krolewski J., Shen J., and Tang D. MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes. Nature Communications, 2017, 8:14270.
Zhang, D*., Lin, K., Lu, Y., Rycaj, K., Zhong, Y., Chao, H.P., Davis, T., Shen, J., and Tang, D.G*. Developing a Novel Two-Dimensional Culture System to Enrich Human Prostate Luminal Progenitors That Can Function as a Cell of Origin for Prostate Cancer. Stem Cells Translational Medicine, 2016, 5:1-13. (*Co-corresponding authors)
Zhang, D*., Park, D., Zhong, Y., Lu, Y., Gong, S., Chen, X., Liu, X., Chao, H.P., Whitney, P., Davis, T., Takata, Y., Shen, J., Iyer, V.R., Tang, D.G*. Stem cell and neurogenic gene expression profiles link prostate basal cells to aggressive prostate cancer. Nature Communications, 2016, 7:10798. (*Co-corresponding authors)
Zhang D*. Transcriptome profiling links the intrinsic properties of human prostate basal cells to prostate cancer aggressiveness. Molecular & Cellular Oncology, 2016, 3:3, e1168508. (*Corresponding author)
Zhang D, Jiang P, Xu Q, Zhang X. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. Journal of Biological Chemistry. 2011, 286(20):17746-54.
Zhang DX, Li XP, Sun SC, Shen XH, Cui XS, Kim NH. Involvement of ER-Ca2+ signaling in the regulation of porcine oocyte meiotic maturation and maternal gene expression. Molecular Reproduction and Development. 2010, 77(5):462-471.