A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery


Study Number
924720
Phase
II
Age Group
Pediatric
Purpose

This phase II trial studies the side effects and how well nirogacestat works in treating patients with desmoid tumors that has grown after at least one form of treatment by mouth or in the vein that cannot be removed by surgery. Nirogacestat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Full Title

(ARST1921) A Safety, Pharmacokinetic and Efficacy Study of a gamma-Secretase Inhibitor, Nirogacestat (PF-03084014; IND# 146375),in Children and Adolescents with progressive, Surgically Unresectable Desmoid Tumors

ClinicalTrials.Gov ID
NCT04195399

To inquire about participating in these studies, call 1-800-ROSWELL (1-800-767-9355) or e-mail askroswell@roswellpark.org.