(COG ACCL0933) A Randomized Open-Label Trial of Caspofungin Versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML)
Description: 

This study will utilize a two-arm, open-label randomized design to evaluate the efficacy of prophylaxis with caspofungin in comparison with fluconazole in children with de novo, relapsed or secondary AML. Study agent will begin following completion of each course of chemotherapy and continue through periods of neutropenia. It will also evaluate the usefulness of the Platelia EIA Aspergillus galactomannan (GM) assay as well as the beta-D glucan testing in early diagnosis of IFI.

Study Number: 

NCG 206811

Phase: 
III
Principal Investigator: 
ClinicalTrials.Gov ID: 
NCT01307579

To inquire about participating in these studies, call 1-877-ASK-RPCI (1-877-275-7724) or e-mail askrpci@roswellpark.org.