A Phase I Clinical Trial of Oral Calcitriol with Fixed Dose of Cisplatin and Gemcitabine in Patients with Advanced Solid Tumors

To determine the maximum tolerated dose of oral calcitriol when combined with a standard dose of gemcitabine and cisplatin in a 28-day cycle. Secondary Objective: Describe the toxicity of this combination using CTCAE version 4.0. Study the pharmacokinetics of calcitriol at the MTD in an expanded cohort of 6 patients. Describe the clinical activity associated with this regimen in this advanced solid tumor population.

Study Number: 

I 163509

Principal Investigator: 
ClinicalTrials.Gov ID: 

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