Taking Diagnosis to a New Level

Pathology: A Key Priority

Our dedicated team of board-certified hematopathologists performs stateof-the-art integrated diagnostic hematopathology—essential to diagnosing and classifying hematolymphoid neoplasms according to the most recent WHO classification.

Pathology is not just looking at cells under the microscope anymore. The integrated diagnostic approach is based on comprehensive clinical, morphologic, immunophenotypic, cytogenetic and molecular genetic studies of lymph node, bone marrow, blood and other extranodal and extramedullary tissue samples. George Deeb, MD, Assistant Professor, Director of Hematopathology, Department of Pathology & Laboratory Medicine; and Associate Director, Flow and Image Cytometry

Hematopathologists work closely with the Lymphoma clinical team and with other ancillary laboratories at RPCI to expedite prompt, comprehensive assessments. The ancillary laboratories incorporate the following:

  • Bone marrow laboratory
  • Immunohistochemistry laboratory with wide arrays of markers available
  • Flow and image cytometry laboratory with spectrum of comprehensive panels of markers to thoroughly characterize hematolymphoid neoplasms immunophenotypically
  • Cytogenetic laboratory with karyotypic analysis and large number of FISH probes for many types of genetic abnormalities
  • Molecular diagnostic laboratory with a plethora of PCR and sequencing-based analyses

Going with the Flow

RPCI’s Flow and Image Cytometry Facility—recognized as one of the nation’s first and finest—analyzes cell samples for RPCI clinicians and researchers, leading health centers and many National Institutes of Health clinical studies. This unique facility specializes in leukemias and lymphomas, identifying specific cancer types and subtypes by determining the specific antigen expression of the tumor using analyses with antibodies and sophisticated laser-activated flow cytometry.