Mass Spectrometry Scientist

Post #
Health Research Inc. (HRI) Roswell Park Division
Pharmacology & Therapeutics
Full-time; Days
HRI offers a competitive salary and comprehensive benefits package.
Description of Duties

The Mass Spectrometry Scientist performs a variety of routine and specialized laboratory procedures within the Bioanalytics, Metabolomics and Pharmacokinetics Shared Resource to support investigator-led studies, which typically contribute to larger collaborative research projects and grants. The Mass Spectrometry Scientist should have a strong working knowledge of chemistry and LC-MS/MS techniques in addition to sample processing techniques (e.g., protein precipitation, liquid/liquid extraction, solid phase extraction, and derivatizations). They will independently develop and validate analytical assays for anticancer drugs and their metabolites, biomarkers, and endogenous compounds in biological matrices (e.g., plasma, urine, cell pellets, tissues, formulated products, etc.) using LCMS/ MS, HPLC with UV and fluorescence detection, AA, or ELISA. They will also oversees the development of assays for new compounds including compound optimization, extraction procedures and chromatography. The Mass Spectrometry Scientist also develops and implements the necessary standard operating procedures, method outlines, validation reports and study reports for the associated projects, develops a thorough knowledge of each research study, operates various instruments for assay development with appropriate quality control, and oversees the workload of technical staff for the timely completion of project conduct; records and checks results for completeness and accuracy, and troubleshoots problems as necessary.


Applicants must have a Doctorate degree in Analytical Chemistry or a related field specializing in mass spectrometry; or a Master’s degree in Analytical Chemistry or a related field and the equivalent of three years of full-time experience specializing in mass spectrometry. The preferred candidate will have working knowledge of chemistry, HPLC, and mass spectrometry . The will also have additional capabilities regarding Sciex 5500 QTrap triple quadrupole, Sciex 5500 triple quadrupole, and Thermo Vantage mass spectrometers, and experience in bioanalytical analysis, GLP/GMP/SOP compliance, untargeted/targeted metabolomics, grant writing, and Microsoft Office Word and Excel.

This is a grant-funded position.  Compliance with funding requirements such as time and effort reporting, grant deliverables, and contract deliverables is required.

Health Research Incorporated (HRI) Roswell Park Division participates in the E-Verify program.

Affirmative Action/Equal Opportunity Employer/Qualified Individuals with Disabilities/Qualified Protected Veterans

Applicant Instructions

Applicants must reference the Posting # when applying for this position.

Interested applicants may apply by uploading a cover letter and resume below in Microsoft Word or PDF format.