Thanks to a National Cancer Institute (NCI) grant, I am leading a team of researchers at Roswell Park to study gender disparities in bladder cancer that will hopefully lead to bladder cancer prevention.
For several decades, it’s been known that bladder cancer is about four times more likely to occur in men than in women, but the reason why this happens is still a mystery. Some studies suggest that this phenomenon is related to the male hormone androgen. It appears that the androgen and the androgen receptor system somehow make the male bladder more sensitive to carcinogens. It’s also possible that the androgen and androgen receptor system affects the liver and this in turn causes more excretion of bladder carcinogens in the urine of men.
Our research will focus on two things. First, we hope to decipher the molecular basis for the increased risk of cancer in the male bladder. And second, we hope that the findings and knowledge we obtain from this research can be used to devise some method to prevent this disease.
We are very excited about this research and believe it will lead to increased knowledge of bladder cancer biology. This grant will provide much needed resources as we continue to study and strive for prevention.
It’s important to know the risk factors associated with bladder cancer. Men especially should become familiar with the following: