Bladder Cancer Research

  • There is a lot of evidence that if you expose cancer cells to high-dose vitamin D along with chemotherapy, it will kill cancer cells. Vitamin D and chemo are better together than alone. - Donald Trump, MD, FACP, Roswell Park President and CEO

Any new treatment undergoes years, even decades, of study and clinical studies, which involve people, encompass the final phases of cancer treatment research. Participating in a clinical study may be an important treatment option for many patients, who may be among the first to benefit from a new drug or therapy. About 50 percent of Roswell Park patients are eligible for a clinical study.

Cancer Vaccine: RPCI recently launched a Phase I trial to test the efficacy and safety of a dendritic cell vaccine designed to both eradicate cancer cells and prevent disease relapse. Dendritic cells are the gatekeepers of the human immune system, defending against invaders like bacteria, viruses and cancer. The vaccine is expected to show great promise in patients with bladder, brain, breast, esophageal, gastrointestinal, hepatocellular, kidney, lung, melanoma, ovarian, prostate, sarcoma and uterine tumors. Developed at RPCI, the NY-ESO-1 dendritic cell vaccine will be manufactured in the Institute’s new Therapeutic Cell Production Facility using a unique FDA-approved process.

Broccoli Sprout Extract: This Phase I study is examining the side effects of broccoli sprout extract in treating patients with transitional cell bladder cancer who will undergo surgery. Broccoli sprout extract contains ingredients that may prevent or slow the growth of certain cancers.

Vitamin D Therapy: In one of the highest nationally funded programs at Roswell Park, Donald Trump, MD, President and CEO of RPCI — and a practicing medical oncologist — and his colleague Candace Johnson, PhD, the Robert, Anne, and Lew Wallace Chair in Translational Research, are analyzing the potential of vitamin D in cancer prevention and treatment.

Dr. Trump has significant experience with the clinical aspects of vitamin D in the treatment of solid tumors and has performed more cancer clinical trials with vitamin D than anyone else in the world.

A Phase I study will determine the safety of combining oral calcitriol (vitamin D) with the conventional chemotherapy agents cisplatin and gemcitabine, drugs used to treat bladder cancer.

A Phase II study will follow to examine the benefits of giving vitamin D plus chemotherapy prior to removal of the bladder in patients with bladder cancer that has penetrated the muscle. Studies thus far have shown significant delay in cancer cell growth, delay in the progression of tumors and prolonged survival when vitamin D is incorporated into treatment.

Participate In a Clinical Trial

Clinical research studies are available to patients with all stages of bladder cancer. Search available clinical research studies for bladder cancer patients at Roswell Park, or call 1-877-ASK-RPCI (1-877-275-7724).