Vector Development and Production Facility

The Vector Development and Production Facility (VDPF) occupies 1331 sq. ft. of space on the 6th floor of Gratwick Basic Science Building (GBSB). Key to the Center for Immunotherapy (CFI), the VDPF generates clinical-grade vectors/reagents that allow the genetic engineering of a patient’s cells, boosting their ability to efficiently fight cancer. The facility follows current good manufacturing practices (cGMP), manufacturing products that meet specific requirements for identity, strength, quality, and purity in the pharmaceutical field, ensuring that the generated viral vector product is suitable for clinical use and compliant with FDA guidelines. The facility manufactures gamma-retroviral and lentiviral vectors required by different investigators or sponsors.

Equipment

Clinical Grade Vector for Gene Therapy Trial.
  • Tangential flow filtration and Diafiltration System (KMPI KROSFLO M.KROS and KLOSFLO R IIii)
  • Automated Hollow Fiber Bioreactor System
  • Isensix Alarm system
  • ChemiDoc
  • Synergy HTX Microplate absorbance reader
  • PCR cycler instruments
  • 6-foot biosafety cabinets
  • Heracell incubators
  • SORVALL centrifuges
  • Liquid Nitrogen storage containers
  • -80 C, -20 C freezers
  • Inverted microscopes

Staff

Richard C. Koya, MD, PhD
Director
Phone: 716-845-1300 ext. 6582
Email: richard.koya@roswellpark.org

Cindy Bonura, BS
Research Associate
Phone: 716-845-1300 ext. 6345
Email: cindy.bonura@roswellpark.org

Satoko Matsueda, PhD
Affiliate Member
Phone: 716-845-1300 ext. 5477
Email: satoko.matsueda@roswellpark.org

Bryan Pratt, MS
Laboratory Technician
Phone: 716-845-1300 ext. 6471
Email: bryan.pratt@roswellpark.org

Vikas Tahiliani, PhD
HRI Scientist
Phone: 716-845-1300 ext. 6075
Email: vikas.tahiliani@roswellpark.org