Dr. Arindam Sen Dr. Arindam Sen

Arindam Sen

PhD

Special Interests:

Structure-function relationship of biological membranes Model membrane systems Biomolecules using biophysical techniques including microscopy, spectroscopy, x-ray Electron diffraction

Credentials

Positions

Roswell Park Comprehensive Cancer Center
  • Department of Immunology
  • Director of Graduate Studies and Admissions
  • Molecular and Cellular Biophysics and Biochemistry Graduate Program

Background

Education and Training:

  • BSc (Physics) Delhi University, Delhi, India
  • MSc (Physics) Delhi University, Delhi, India
  • PhD (Life Sciences) J. Nehru University, N. Delhi, India

Research

Research Overview:

My general research interests include structure-function relationship of biological membranes, model membrane systems and biomolecules using biophysical techniques including microscopy, spectroscopy, x-ray and electron diffraction. My specialization is in the area of electron, optical and atomic force microscopy and, uv/vis and infrared spectroscopic techniques. Specific interests include developing strategies for parenteral drug delivery including transdermal, lipidic nanoparticles and macromolecular assemblies as drug delivery systems, and the development of biosensors using planar immobilized assemblies of biomolecules. Further, we are investigating the physical barriers posed by the tumor microenvironment on effective chemo and radiation therapy, and possible approaches for overcoming those barriers.

Current Program:
Transdermal Drug Delivery and Analyte Monitoring

Lipidic Nanoparticles for Drug Delivery

Tumor Microenvironment

Development of biosensors


Publications

Rustum YM, T�th K, Seshadri M, Sen A, Durrani FA, Stott E, Morrison CD, Cao S, Bhattacharya A. Architectural heterogeneity in tumors caused by differentiation alters intratumoral drug distribution and affects therapeutic synergy of antiangiogenic organoselenium compound. Journal of oncology2010; 2010 :396286

Bhattacharya A, Toth K, Sen A, Seshadri M, Cao S, Durrani FA, Faber E, Repasky EA, Rustum YM. Inhibition of colon cancer growth by methylselenocysteine-induced angiogenic chemomodulation is influenced by histologic characteristics of the tumor. Clinical colorectal cancer 2009;8(3):155-162

Sen A, Capitano ML, Spernyak JA, Schueckler JT, Thomas S, Singh AK, Evans SS, Hylander BL, Repasky EA. Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer research 2011; 71(11):3872-3880

Sckolnick M, Hui SW, Sen A. Influence of DMPS on the water retention capacity of electroporated stratum corneum: ATR-FTIR study. International journal of pharmaceutics 2008; 350(1-2):138-144

Burgess SE, Zhao Y, Sen A, Hui SW. Resealing of electroporation of porcine epidermis using phospholipids and poloxamers. International journal of pharmaceutics 2007; 336(2):269-275

Xu Y, Choi J, Hylander B, Sen A, Evans SS, Kraybill WG, Repasky EA. Fever-range whole body hyperthermia increases the number of perfused tumor blood vessels and therapeutic efficacy of liposomally encapsulated doxorubicin.International journal of hyperthermia 2007; 23(6):513-527

Capitano ML, Schueckler JT, Jaggernauth W, Sen A, Repasky EA. Fever-range whole body hyperthermia increases the efficacy of radiation therapy by selectively increasing the percentage of perfused tumor blood vessels.Proceedings of the American Association for Cancer Research Annual Meeting2008; 49:1371

Srivatsan A, Rao KVR, Chen Y, Wang Y, Batt C, Morgan J, Sen A, Repasky E, Pandey RK. Effect of hyperthermia on PDT and imaging. Proceedings of SPIE : Biomedical Optics and Medical Imaging 2009; 7380:73805V