Alejandro Godoy

Alejandro Godoy

PhD

About Me

Biography:

Dr. Godoy earned his PhD in Cellular and Molecular Biology from the University of Concepción, Concepción, Chile. He completed a research fellowship, and post-doctoral fellowship training in Cancer Biology at Roswell Park.

Dr. Godoy has received numerous awards and fellowships. Most recently, he received the Outstanding Post-Doctoral Fellow Presentation award in 2010 from Roswell Park’s GU Program Research Retreat. Dr. Godoy also received the Post-Doctoral Prostate Cancer Training Award from the Department of Defense (2008-2010) for his work as Principal Investigator on the study, “Androgen Effects on Human Prostate Endothelial Cells.

Currently, Dr. Godoy is the Principal Investigator on the study, “Role of Fructose in Prostate Cancer.” For this study, he was recognized with the Idea Development Award (New Investigator) by the Department of Defense. The goal of this project is to understand the biological role of fructose and fructose transporters in the development and progression of prostate cancer.

Dr. Godoy presently has two patents pending, and is an ad hoc reviewer for the Journal of Cellular and Molecular Medicine, PLoS One, Molecular Medicine and Neoplasia. He has also been published in many peer-reviewed journals and has contributed to a book chapter in Recent Advances in Prostate Cancer: Basic Science Discoveries and Clinical Advances.

Dr. Godoy is an Associate Member of the American Associate for Cancer Research, In-Training Member of the Society for Basic Urologic Research, and Co-founder and Executive Committee Member (2008-2009) of the Association of Post-Doctoral Scholars at Roswell Park Comprehensive Cancer Center.


Credentials

Positions

Roswell Park Comprehensive Cancer Center
  • HRI Scientist (Junior Faculty)

Publications

Godoy A, Salazar K, Figueroa C, Smith GJ, de los Angeles Garcia M, Nualart FJ. Nutritional channels in breast cancer. Journal of cellular and molecular medicine 2009; 13(9B):3973-3984

Mathew G, Timm Jr EA, Sotomayor P, Godoy A, Montecinos VP, Smith GJ, Huss WJ. ABCG2-mediated DyeCycle Violet efflux defined side population in benign and malignant prostate. Cell cycle (Georgetown, Tex.) 2009; 8(7):1053-1061

Sotomayor P, Godoy A, Smith GJ, Huss WJ. Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. Prostate 2009; 69(4):401-410

Godoy A, Montecinos VP, Gray DR, Sotomayor P, Yau JM, Vethanayagam RR, Singh S, Mohler JL, Smith GJ. Androgen deprivation induces rapid involution and recovery of human prostate vasculature. American journal of physiology. Endocrinology and metabolism 2011; 300(2):E263-E275

Tanner MJ, Welliver Jr RC, Chen M, Shtutman M, Godoy A, Smith G, Mian BM, Buttyan R. Effects of androgen receptor and androgen on gene expression in prostate stromal fibroblasts and paracrine signaling to prostate cancer cells.PloS one 2011; 6(1):e16027

Godoy A, Kawinski E, Li Y, Oka D, Alexiev B, Azzouni F, Titus MA, Mohler JL.5alpha-reductase type 3 expression in human benign and malignant tissues: a comparative analysis during prostate cancer progression. Prostate 2011;71(10):1033-1046

Godoy A, Watts A, Sotomayor P, Montecinos VP, Huss WJ, Onate SA, Smith GJ. Androgen receptor is causally involved in the homeostasis of the human prostate endothelial cell. Endocrinology 2008; 149(6):2959-2969

Cano P, Godoy A, Escamilla R, Dhir R, Onate SA. Stromal-epithelial cell interactions and androgen receptor-coregulator recruitment is altered in the tissue microenvironment of prostate cancer. Cancer research 2007; 67(2):511-519

Godoy A, Rivas CI, Carcamo JG, Reyes AM, Onate SA, Aguayo LG, Villagran M, Guzman C, Mardones L, Montecinos V, Vasquez O, Barra V, Sotomayor P, Zuniga FA, Moraga-Cid G, Ormazabal V, Vera JC. Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by sodium and absolute dependence on bivalent cations.Journal of biological chemistry 2007; 282(1):615-624

Montecinos V, Vasquez O, Gallardo V, van Zundert B, Bono MR, Onate SA, Bustamante M, Carcamo JG, Rivas CI, Guzman C, Sotomayor P, Guzman P, Barra V, Villagran M, Munoz-Montesino C, Sotomayor K, Escobar E, Godoy A, Mardones L, Vera JC. Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione. Journal of biological chemistry2007; 282(21):15506-15515

Chadha KC, Nair BB, Chakravarthi S, Zhou R, Godoy A, Mohler JL, Aalinkeel R, Schwartz SA, Smith GJ. Enzymatic activity of free-prostate-specific antigen (f-PSA) is not required for some of its physiological activities. Prostate 2011;71(15):1680-1690

Hidalgo AA, Trump D, Johnson C, Pantoja D, Tovar H, McNerney EM, Godoy AS, Paredes R, Montecinos VP, Onate SA. Biochemical characterization of nuclear receptors for vitamin D3 and glucocorticoids in prostate stroma cell microenvironment. Biochemical and biophysical research communications2011; 412(1):13-19

Godoy AS, Sotomayor P, Warts A, Montecinos VP, Vethanayagam RR, Smith GJ. Androgen-ablation modulates human prostate endothelial cell phenotype.Proceedings of the American Association for Cancer Research Annual Meeting2008; 49:257

Godoy AS, Watts A, Sotomayor PC, Montecinos VP, Huss WJ, Smith GJ.Functional characterization of androgen receptor in human prostate endothelial cells. Proceedings of the American Association for Cancer Research Annual Meeting 2007; 48:1094

Godoy AS, Watts A, Sotomayor PC, Montecinos VP, Onate SA, Huss WJ, Smith GJ. Human prostate endothelial cells as a first-line target for androgens.BJU international 2007; 100(Suppl. 3):8

Montecinos VP, Godoy AS, Stafford JA, Huss WJ, Smith GJ. Rapid angiogenesis in an in vivo model of primary human prostate xenografts.Proceedings of the American Association for Cancer Research Annual Meeting2007; 48:725

Montecinos VP, Stafford J, Godoy A, Smith GJ. Role of microenvironmental VEGF distribution in human prostate angiogenesis. BJU international 2007;100(Suppl. 3):33

Sotomayor P, Godoy A, Smith G, Huss W. Oct4 expression in benign and prostate cancer neuroendocrine cells. BJU international 2007; 100(Suppl. 3):40

Montecinos VP, Godoy A, Hinklin J, Vethanayagam RR, Smith GJ. Primary xenografts of human prostate tissue as a model to study angiogenesis induced by reactive stroma. PloS one 2012; 7(1):e29623

Reinicke K, Sotomayor P, Cisterna P, Delgado C, Nualart F, Godoy A. Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue. Journal of cellular biochemistry 2012; 113(2):553-562

Azzouni F, Godoy A, Li Y, Mohler J. The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. Advances in urology2012; 2012 :530121

Godoy AS, Sotomayor PC, Villagran M, Yacoub R, Montecinos VP, McNerney EM, Moser M, Foster BA, Onate SA. Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression. Biochemical and biophysical research communications 2012; 423(3):564-570