Dr. Aimin Jiang joined the faculty of Roswell Park Comprehensive Cancer Center (RPCI) in 2008 as an Assistant Member in the Department of Immunology. Dr. Jiang came to RPCI from Yale University School of Medicine, New Haven, CT, where he served in the Department of Immunology.
Dr. Jiang earned his doctoral degree in the Department of Microbiology (2002) from the University of Washington, Seattle, WA.
Dr. Jiang’s research interests include intracellular and intercellular signaling in dendritic cell function which regulates the body’s immune response to pathogens. Dr. Jiang and colleagues had recently uncovered a novel mechanism which matures dendritic cells but renders them unable to mount immune responses to foreign pathogens. His current research is focused on understanding the role of regulation of dendritic cells in immunity and tolerance in autoimmune diseases and cancer with the goal of developing new therapeutic treatments.
Dr. Jiang has authored or co-authored more than 20 journal abstracts, papers and book chapters.
Investigate the role of beta-catenin signaling in DC-mediated tolerance against tumor and anti-tumor immunity.
Defining cellular and molecular mechanisms for the regulation of autoimmunity by beta-catenin.
Fu C, Liang X, Cui W, Ober-Blobaum JL, Vazzana J, Shrikant PA, Clausen BE, Lee KP, Mellman I, and Jiang A. beta-catenin in dendritic cells exerts opposite function in cross-priming and maintenance of CD8+ T cells through regulation of IL-10. Proceedings of the National Academy of Sciences. 112(9): 2823-2828, 2015
Liang X, Fu C, Cui W, Ober-Blobaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, and Jiang A. beta-Catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8+ T cells. Journal of Leukocyte Biology. 95: 179-190, 2014
Fu C and Jiang A. Generation of tolerogenic dendritic cells via the E-cadherin/beta-catenin-signaling pathway. Immunologic Research. 46, 72-78, 2010
Jiang A, Bloom O, Ono S, Cui W, Unternaehrer J, Jiang S, Whitney JA, Connolly J, Banchereau J, and Mellman I. Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity. 27: 610-624, 2007
Jiang A, Craxton A, Kurosaki T, and Clark EA. Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal Kinase 1, and p38 mitogen-activated protein kinase. Journal of Experimental Medicine. 188:1297-1306, 1998