Correlation of Deuterated Phenanthrene Metabolism with Bronchoepitheial Dysplasia and Metaplasia in Smokers at High Risk for Lung Cancer

Title Correlation of Deuterated Phenanthrene Metabolism with Bronchoepitheial Dysplasia and Metaplasia in Smokers at High Risk for Lung Cancer

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Principal Investigator Alex Adjei, MD PhD

Study Number 194611

PhasePilot

Summary

The purpose of this study is to see if how an individual processes deuterated phenanthrene can help predict who is at higher risk of developing abnormalities that can be detected with bronchoscopy and therefore may be a higher risk of developing tobacco smoke-related lung cancer.

Eligibility

Inclusion Criteria:

Enrolled in the HRLC Screening Program
Eligible for bronchoscopy or have undergone screening bronchoscoy in the past
Age >= 18
Current smoker of at least 10 cigarettes daily
Able to provide written consent indicating an understanding of the investigational nature of the study
Willing to take [D10] phenanthrene in water with 20% ethanol

Exclusion Criteria:

Previous aerodigestive tract cancer
Currently attempting to cut down or quit smoking
Major medical co-morbidities, for example, renal dysfunction, heart failure, and diabetes, to be adjudicated by the study physicians
Pregnant women, women intending to become pregnant, or women who are breast feeding

For more information about the clinical study go to Clinicaltrial.Gov