Patients with small peripheral NSCLC will be randomly assigned to either lobectomy or a sublobar resection (wedge resection or segmentectomy). The surgeon will determine if the tumor is the correct size (<2cm) during surgery to qualify a patient for this protocol. At that time the information will be entered into the computer program to randomize the patient to a lobectomy or to sublobar resection. Patients will be followed yearly up to 5 years to determine whether disease free survival (DFS) is non-inferior following sublobar resection compared to lobectomy.
An imaging substudy is also embedded in this protocol to compare pre-operative CT or PET scan imaging characteristics with survival rate and rate of tumor recurrence outcomes.
PRE REGISTRATION CRITERIA
- Peripheral lung nodule < or = 2cm on CT and presumed to be lung cancer
- Tumor location suitable for either lobar or sublobar resection
- ECOG PS: 0-2
- No prior malignancy within 3 years
- No prior chemotherapy or radiation therapy for this malignancy
- No evidence of locally advanced or metastatic disease
- Age > or = 18 years
INTRA-OPERATIVE RANDOMIZATION CRITERIA
- Histologic confirmation of NSCLC
- Confirmation of N0 status