Robert Fenstermaker, MD

Professor of Neurosurgery and Oncology

Chair, Department of Neurosurgery

Director, Neuro-Oncology Program

Roswell Park Cancer Institute

Professor of Neurosurgery and Oncology

School of Medicine and Biomedical Sciences, State University of New York at Buffalo

Profile

Areas of Expertise:

Brain Tumor Surgery

Skull Base Surgery

Pituitary Tumor Surgery

Trigeminal Neuralgia

Gamma Knife Radiosurgery

Research

Research Interests:

Immunotherapy for the treatment of malignant brain tumors

Selected Publications:

1. Antitumor cytotoxic T-cell response induced by a survivin peptide mimic. Ciesielski MJ, Ahluwalia MS, Munich SA, Orton M, Barone T, Chanan-Khan A, Fenstermaker RA. Cancer Immunol Immunother. 2010 Aug;59(8):1211-21. Epub 2010 Apr 27.

2. Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors. Yang W, Barth RF, Wu G, Huo T, Tjarks W, Ciesielski M, Fenstermaker RA, Ross BD, Wikstrand CJ, Riley KJ, Binns PJ. J Neurooncol. 2009 Dec;95(3):355-65. Epub 2009 Jul 9.

3. Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting. Paul AK, Ciesielski MJ, Sajjad M, Wang X, Ferrone S, Abdel-Nabi H, Fenstermaker RA. J Neurooncol. 2009 Aug;94(1):21-30. Epub 2009 Jan 20.

4. Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells. Wierzbicki A, Gil M, Ciesielski M, Fenstermaker RA, Kaneko Y, Rokita H, Lau JT, Kozbor D. J Immunol. 2008 Nov 1;181(9):6644-53.

5. EGFR Intron Recombination in Human Gliomas: Inappropriate Diversion of V(D)J Recombination? Fenstermaker RA, Ciesielski MJ. Curr Genomics. 2007 May;8(3):163-70.

6. Central nervous system cancers. Brem SS, Bierman PJ, Black P, Brem H, Chamberlain MC, Chiocca EA, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Glass J, Grossman SA, Heimberger AB, Junck L, Linette GP, Loeffler JJ, Maor MH, Moots P, Mrugala M, Nabors LB, Newton HB, Olivi A, Portnow J, Prados M, Raizer JJ, Shrieve DC, Sills AK Jr. J Natl Compr Canc Netw. 2008 May;6(5):456-504.

7. Therapeutic effect of a T helper cell supported CTL response induced by a survivin peptide vaccine against murine cerebral glioma. Ciesielski MJ, Kozbor D, Castanaro CA, Barone TA, Fenstermaker RA. Cancer Immunol Immunother. 2008 Dec;57(12):1827-35. Epub 2008 Apr 26.

Background Information

Education and Training:

MD - Northeastern Ohio Universities College of Medicine, Rootstown, OH

Residency:

University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, OH

Board Certification:

Neurological Surgery, American Board of Neurological Surgery

Fellowships:

Case Western Reserve University School of Medicine (Biochemistry and Pharmacology) Cleveland, OH

Publications

Publications:

Ciesielski MJ, Ahluwalia MS, Munich SA, Orton M, Barone T, Chanan-Khan A, Fenstermaker RA. Antitumor cytotoxic T-cell response induced by a survivin peptide mimic. Cancer immunology, immunotherapy : CII 2010; 59(8):1211-1221
Ciesielski MJ, Munich SA, Clements JL, Hangauer DG, Dyster LM, Barnett A, Fenstermaker RA. KX02 a novel therapeutic for glioma. Proceedings of the American Association for Cancer Research Annual Meeting 2010; 51:1358
Fabiano AJ, Rigual NR, Belber CS, Fenstermaker RA. Endoscopic sellar floor reconstruction with concha bullosa bone autograft and nasal septal flap: technical case report. Minimally invasive neurosurgery : MIN 2009; 52(2):86-88
Paul AK, Ciesielski MJ, Sajjad M, Wang X, Ferrone S, Abdel-Nabi H, Fenstermaker RA. Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting. Journal of neuro-oncology 2009; 94(1):21-30
Yang W, Riley KJ, Wikstrand CJ, Ross BD, Fenstermaker RA, Ciesielski M, Tjarks W, Huo T, Wu G, Barth RF, Binns PJ. Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors. Journal of neuro-oncology 2009; 95(3):355-365
Brem SS, Michael M, Moots PL, Morrison T, Mrugala M, Nabors LB, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK Jr, Vrionis FD, Maor MH, Loeffler JS, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Chiocca EA, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Junck L, Linette GP, Wen PY. Central nervous system cancers. Journal of the National Comprehensive Cancer Network : JNCCN 2011; 9(4):352-400
Ciesielski MJ, Kozbor D, Castanaro CA, Barone TA, Fenstermaker RA. Therapeutic effect of a T helper cell supported CTL response induced by a survivin peptide vaccine against murine cerebral glioma. Cancer immunology, immunotherapy : CII 2008; 57(12):1827-1835
Karampelas I, Podgorsak MB, Plunkett RJ, Fenstermaker RA. Subthalamic nucleus metastasis causing hemichorea-hemiballism treated by gamma knife stereotactic radiosurgery. Acta neurochirurgica 2008; 150(4):395-396; discussion 397
Wierzbicki A, Gil M, Ciesielski M, Fenstermaker RA, Kaneko Y, Rokita H, Lau JT, Kozbor D. Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells. Journal of immunology (Baltimore, Md. : 1950) 2008; 181(9):6644-6653
Yang W, Fenstermaker RA, Ciesielski MJ, Riley KJ, Binns PJ, Sferra TJ, Moeschberger M, Tordoff K, Tjarks W, Bandyopadhyaya AK, Swindall MR, Barth RF, Wu G, Wikstrand CJ. Molecular targeting and treatment of composite EGFR and EGFRvIII-positive gliomas using boronated monoclonal antibodies. Clinical cancer research 2008; 14(3):883-891
Fenstermaker RA, Ciesielski MJ. EGFR Intron Recombination in Human Gliomas: Inappropriate Diversion of V(D)J Recombination? . Current genomics 2007; 8(3):163-170
Karampelas I, Alberico RA, Plunkett RJ, Fenstermaker RA. Intratumoral hemorrhage after remote subtotal microsurgical resection and gamma knife radiosurgery for vestibular schwannoma. Acta neurochirurgica 2007; 149(3):313-316; discussion 316-7
Karampelas I, Cole PM, Kuensting JM, Fenstermaker RA. Diagnosis and conservative management of an arteriovenous fistula of the scalp following awake craniotomy for tumor resection. Acta neurochirurgica 2007; 149(7):727-728; discussion 728
Kowalczyk A, Ciesielski M, Brecher M, Fenstermaker R, Repasky E, Rokita H, Kaneko Y, Bambach B, Gil M, Wierzbicki A, Kozbor D. Induction of protective immune responses against NXS2 neuroblastoma challenge in mice by immunotherapy with GD2 mimotope vaccine and IL-15 and IL-21 gene delivery. Cancer immunology, immunotherapy : CII 2007; 56(9):1443-1458
Wu G, Ciesielski MJ, Riley KJ, Binns PJ, Sferra TJ, Christoforidis GA, Yang M, Ferketich AK, Blue TE, Khorsandi B, Tjarks W, Bandyopadhyaya AK, Swindall M, Kawabata S, Barth RF, Yang W, Fenstermaker RA. Molecular targeting and treatment of an epidermal growth factor receptor-positive glioma using boronated cetuximab. Clinical cancer research 2007; 13(4):1260-1268
Chen Y, Oseroff A, Fenstermaker R, Kadish KM, Fukuzumi S, Erin T, Baumann H, Ciesielski M, Pandey SK, Liu W, Wenbo E, Zhang M, Ohkubo K, Pandey RK. Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy. Photochemical and photobiological sciences 2007; 6(12):1257-1267
Reddy N, Karampelas I, Chanan-Khan A, Fenstermaker R, Padmanabhan S. Aggressive relapse of multiple myeloma with intracerebral extension and associated hemorrhage. Leukemia and lymphoma 2007; 48(6):1228-1230
Gruber TJ, Fabiano AJ, Deeb G, Lele SB, Fenstermaker RA. Intracranial meningiomas in patients with uterine sarcoma treated with long-term megestrol acetate therapy. World neurosurgery 2011; 76(5):477.e16-477.e20
Fabiano AJ, Rigual N, Munich S, Fenstermaker RA. Esthesioneuroblastoma resection via the expanded endonasal endoscopic approach. Neuro-oncology 2011; 13(Suppl. 3):156-157
Jarrett SG, Novak M, Dabernat S, Daniel JY, Mellon I, Zhang Q, Harris N, Ciesielski MJ, Fenstermaker RA, Kovacic D, Slominski A, Kaetzel DM. Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis. Cancer research 2012; 72(1):133-143
Shen L, Ciesielski M, Ramakrishnan S, Miles KM, Ellis L, Sotomayor P, Shrikant P, Fenstermaker R, Pili R. Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models. PloS one 2012; 7(1):e30815
Shen L, Ciesielski M, Ellis L, Fenstermaker R, Pili R. Selective class I HDAC inhibitor SNDX-275 enhances anti-tumor survivin vaccine therapy by suppressing regulatory T cells in a model of prostate cancer. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #1792
Ciesielski M, Castanaro C, Barone T, Fenstermaker R. Therapeutic CTL response induced by a survivin molecular mimic vaccine against human glioma. Neuro-oncology 2008; 10(5):809
Qiu JX, Fenstermaker R, Fabiano A. Tumoral Bing-Neel Syndrome Presenting as a Cerebellar Mass. Journal of neuropathology and experimental neurology 2012; 71(6):600 (Abstract #194)

Referral

Email:

Robert.Fenstermaker@RoswellPark.org

Mobile phone:

716-572-1154

Fax:

716-845-8980