Published on Roswell Park Cancer Institute (http://www.roswellpark.org)

Associate Professor, Department of Pathology & Laboratory Medicine
Roswell Park Cancer Institute
Assistant Professor of Pathology & Anatomic Sciences
Academic Scholar
School of Medicine and Biomedical Sciences, State University of New York at Buffalo
Profile
Areas of Expertise: 
Breast pathology
Research
Research Interests: 
Breast cancer
Her2 testing
Background Information
Education and Training: 
MD - University of Damascus, Damascus, Syria
Residency: 
University of Damascus, Damascus, Syria
School of Medicine and Biomedical Sciences, State University of New York at Buffalo
Board Certification: 
Anatomic Pathology, American Board of Pathology
Clinical pathology, American Board of Surgery
Fellowships: 
Roswell Park Cancer Institute, Buffalo, NY
Publications
Publications: 
  • Al-Agha OM, Liu W, Chandrasekhar R, Wilding G, Tan D, Alrawi S, Khoury T. CD138 (Syndecan-1) in thymic neoplasms: correlation with various World Health Organization types and clinical outcome. Laboratory investigation 2010; 90(Suppl. 1):408A
  • Kumar PRG, Grossman Z, Scorza L, Khoury T, Nayyar R. Isolated extramedullary relapse of acute lymphoblastic leukemia in the breast of an adolescent girl: radiologic findings and discussion. Pediatric radiology 2010; 40(5):773-776
  • Xu B, Thong N, Tan D, Khoury T. Expression of thyroid transcription factor-1 in colorectal carcinoma. Applied immunohistochemistry and molecular morphology : AIMM 2010; 18(3):244-249
  • Khoury T, Nowak N, Conroy J, Morrison C, Cheney R, Mojica W, Ademuyiwa F, Wang D, Kanehira K, Liu S. Breast carcinoma with amplified HER2: a gene expression signature specific for trastuzumab resistance and poor prognosis. Modern pathology 2010; 23(10):1364-1378
  • Liu W, Iqbal J, Khoury T. Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases. Journal of cutaneous pathology 2010; 37(11):1145-1149
  • Dhingra S, Feng W, Zhou D, Khoury T, Brown RE, Tan D. Expression of stem cell markers in human gastric adenocarcinoma and non-neoplastic gastric mucosa, a study of 209 cases. Laboratory investigation 2010; 90(Suppl. 1):143A
  • Kanchira K, Zakharia Y, Tan W, Liu W, Wilding G, Edge S, Tan D, Khoury T. Frozen section versus touch preparation for intraoperative detection of sentinel lymph node metastases from breast cancer: A single institution experience of 396 cases. Laboratory investigation 2010; 90(Suppl. 1):54A
  • Khoury T, Kanehira K, Wang D, Ademuyiwa F, Liu S. Gene expression signature as a predictor for trastuzumab resistance in breast carcinoma with amplified HER2. Laboratory investigation 2010; 90(Suppl. 1):55A-56A
  • Khoury T, Zakharia Y, Hwang H, Liu W, Edge S, Tan D, Morrison C. HER2 testing: How to get high concordance rate between immunohistochemistry and fluorescence in situ hybridization. Laboratory investigation 2010; 90(Suppl. 1):56A
  • Liu W, Zakharia Y, Tan W, Wilding G, Edge S, Tan D, Khoury T. Intraoperative detection of sentinel lymph node metastases from breast cancer: Does the pathologist experience, subspecialty or the surgeon experience matter?. Laboratory investigation 2010; 90(Suppl. 1):59A
  • Qiu J, Kulkarni S, Chandrasekhar R, Rees M, Hyde R, Wilding G, Tan D, Khoury T. Delay to formalin fixation effect on estrogen and progesterone receptors in breast cancer: A study of three different clones. Laboratory investigation 2010; 90(Suppl. 1):66A
  • Zhang S, Kasznica J, Chandrasekhar R, Wilding G, Khoury T. Fibroepithelial lesion with cellular stroma: Topoisomerase 2 is a helpful marker to differentiate fibroadenoma from phyllodes tumor on needle core biopsy. Laboratory investigation 2010; 90(Suppl. 1):80A
  • Zhang S, Zakharia Y, Tan W, Wilding G, Edge S, Liu W, Tan D, Khoury T. Breast hormonal receptors test should be repeated on excisional biopsies after negative core biopsy. Laboratory investigation 2010; 90(Suppl. 1):80A
  • Khoury T , Malik D , Fan C , Tan D , Kulkarni S. Modified Alcian blue enhances the intraoperative diagnosis of sentinel lymph node metastasis in invasive lobular carcinoma: a prospective study. Archives of pathology and laboratory medicine 2010; 134(10):1513-1519
  • Merzianu M , Khoury T. Gastrointestinal signet-ring cell carcinoma vs metastatic lobular carcinoma to gastrointestinal tract: an immunohistochemical differential diagnostic strategy. American journal of clinical pathology 2010; 134(4):59
  • Qiu J , Kulkarni S , Chandrasekhar R , Rees M , Hyde K , Wilding G , Tan D , Khoury T. Effect of delayed formalin fixation on estrogen and progesterone receptors in breast cancer: a study of three different clones. American journal of clinical pathology 2010; 134(5):813-819
  • Wang X , Clay TM , Lyerly HK , Barry WT , Hsu DS , Khoury T , Chivukula M , Brufsky A , McCarthy JB , Katayama A , Sakakura K , Yu L , Wang Y , Osada T , Ferrone S. CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer. Journal of the National Cancer Institute 2010; 102(19):1496-1512
  • Kanehira K, Khoury T. Neuroendocrine markers expression in pancreatic serous cystadenoma. Applied immunohistochemistry and molecular morphology : AIMM 2011; 19(2):141-146
  • Khoury T, Kanehira K, Wang D, Ademuyiwa FO, Mojica W, Conroy J, Nowak N, Liu S. Breast carcinoma with amplified HER2: A gene expression signature specific for trastuzumab resistance and poor prognosis. Journal of clinical oncology 2010; 28(15 Suppl.):657
  • Starostik P, Azrak S, Liang P, Wilding GE, Ademuyiwa FO, Khoury T. HER2 testing in breast cancer by universally primed quantitative multiplex PCR short fluorescent fragments (upQMPSF). Journal of clinical oncology 2010; 28(15 Suppl.):e11049
  • Feng W, Zhang W, Xie K, Yao JC, Khoury T, Li W, Truong CD, Song SW, Ylip A, Tan D. Potential signature molecular biomarkers of prognosis of gastric adenocarcinoma: A genome-wide study of 106 cases : 2010 Gastrointestinal Cancers Symposium. Journal of clinical oncology 2010; 28(15 Suppl.):Abstract #16
  • Hassid VJ, Orlando FA, Awad ZT, Dongfeng TAN, Khoury T, Ahmed BH, Alrawi SJ. Genetic and molecular abnormalities in cholangiocarcinogenesis. Anticancer research 2009; 29(4):1151-1156
  • Khoury T, Alrawi S, Ramnath N, Li Q, Grimm M, Black J, Tan D. Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer. Clinical lung cancer 2009; 10(1):58-66
  • Khoury T, Arshad A, Bogner P, Ramnath N, Zhang S, Chandrasekhar R, Wilding G, Alrawi S, Tan D. Apoptosis-related (survivin, Bcl-2), tumor suppressor gene (p53), proliferation (Ki-67), and non-receptor tyrosine kinase (Src) markers expression and correlation with clinicopathologic variables in 60 thymic neoplasms. Chest 2009; 136(1):220-228
  • Khoury T, Sait S, Hwang H, Chandrasekhar R, Wilding G, Tan D, Kulkarni S. Delay to formalin fixation effect on breast biomarkers. Modern pathology 2009; 22(11):1457-1467
  • Kulkarni SA, Seitz RS, Schreeder MT, Estopinal NC, Ring BZ, Beck RA, Khoury T, Hwang H, Murekeyisoni C, Watroba NL, Hicks DG, Ross DT. TLE3 as a candidate biomarker of response to taxane therapy. Breast cancer research : BCR 2009; 11(2):R17
  • Truong CD, Yao J, Xie K, Yu Y, Alrawi S, Li Q, Khoury T, Li W, Feng W, Tan D. Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A. Journal of experimental and clinical cancer research : CR 2009; 28:14
  • Khoury T, Chandrasekhar R, Wilding G, Tan D, Cheney RT. Tumour eosinophilia combined with an immunohistochemistry panel is useful in the differentiation of type B3 thymoma from thymic carcinoma. International journal of experimental pathology 2011; 92(2):87-96
  • Khoury T, Tan D, Monhollen L, Wang Y, Ferrone S, Deleo AB, Gregory W, Chandraseekhar R, Foluso A, Wang X. Association of breast cancer stem cells identified by aldehyde dehydrogenase-1A1 expression with poor prognosis in the conventional cytotoxic neoadjuvant chemotherapy. Laboratory investigation 2011; 91(Suppl. 1):193
  • Khoury T, Rivera L. Foregut duplication cysts: a report of two cases with emphasis on embryogenesis. World journal of gastroenterology : WJG 2011; 17(1):130-134
  • Khoury T, Tan D, Bshara W. HER2 testing: The equivocal category by immunohistochemistry should be expanded to include cases with any 2+ staining and cases with 3+ staining in < 70% instead of < 30% of tumor cells to have high concordance rate with FISH. Laboratory investigation 2011; 91(Suppl. 1):192
  • Khoury T, Zakharia Y, Tan W, Kulkarni S, Liu W, Zhang S, Wilding GE, Edge S. Breast hormonal receptors test should be repeated on excisional biopsy after negative core needle biopsy. Breast journal 2011; 17(2):180-186
  • Monhollen L, Kumar P, Chandrasekhar R, Wilding G, Khoury T. The histopathologic findings of magnetic resonance imaging enhancement of breast lesions with histologically mass-negative lesion: A single institution experience. Laboratory investigation 2011; 91(Suppl. 1):219
  • Monhollen L, Morrison C, Ademuyiwa F, Chanddrasekhar R, Wilding G, Khoury T. Invasive pleomorphic lobular carcinoma: A clinicopathologic and immunohistochemistry study of 40 cases. Laboratory investigation 2011; 91(Suppl. 1):217
  • Monhollen L, Morrison C, Ademuyiwa F, Chandrasekhar R, Wilding G, Khoury T. Pleomorphic lobular carcinoma: Immunohistochemistry study of 27 cases. Laboratory investigation 2011; 91(Suppl. 1):218
  • Turner BM, Kumar P, Chandraseekhar R, Wilding G, Khoury T. Unnecessary subsequent surgery might be avoided for a diagnosis of atypical ductal hyperplasia on a core needle biopsy by evaluating histologic features: A study of 71 cases. Laboratory investigation 2011; 91(Suppl. 1):269
  • Monhollen L, Morrison C, Ademuyiwa F, Chandrasekhar R, Wilding G, Khoury T. Pleomorphic Lobular Carcinoma: Immunohistochemistry Study of 27 Cases. Modern pathology 2011; 24(Suppl. 1):218
  • Orlando FA, Tan D, Baltodano JD, Khoury T, Gibbs JF, Hassid VJ, Ahmed BH, Alrawi SJ. Aberrant crypt foci as precursors in colorectal cancer progression. Journal of surgical oncology 2008; 98(3):207-213
  • Yang J, Li Y, Khoury T, Alrawi S, Goodrich DW, Tan D. Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer. Annals of clinical and laboratory science 2008; 38(2):105-112
  • Agrawal S, Kuvshinoff BW, Khoury T, Yu J, Javle MM, LeVea C, Groth J, Coignet LJ, Gibbs JF. CD24 expression is an independent prognostic marker in cholangiocarcinoma. Journal of gastrointestinal surgery 2007; 11(4):445-451
  • Ailawadhi S, Nagase H, Khoury T, Yu J, Tan D, Black J, Brattain M, Javle M. Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma. Hepato-gastroenterology 2007; 54(77):1339-1344
  • Foster J, Black J, LeVea C, Khoury T, Kuvshinoff B, Javle M, Gibbs JF. COX-2 expression in hepatocellular carcinoma is an initiation event; while EGF receptor expression with downstream pathway activation is a prognostic predictor of survival. Annals of surgical oncology 2007; 14(2):752-758
  • Javle MM, Gibbs JF, Iwata KK, Pak Y, Rutledge P, Yu J, Black JD, Tan D, Khoury T. Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer. Annals of surgical oncology 2007; 14(12):3527-3533
  • Feng W, Zhou Z, Peters JH, Khoury T, Zhai Q, Wei Q, Truong CD, Song SW, Tan D. Expression of insulin-like growth factor II mRNA-binding protein 3 in human esophageal adenocarcinoma and its precursor lesions. Archives of pathology and laboratory medicine 2011; 135(8):1024-1031
  • Khoury T, Kulkarni S, Morrison C, Bshara W, Zakharia Y, Edge S. HER2 Testing: How to Reach a High Concordance Rate Between Immunohistochemistry and Fluorescence In Situ Hybridization. Applied immunohistochemistry and molecular morphology : AIMM 2011; 19(5):424-430
  • Khoury T, Mojica W, Hicks D, Starostik P, Ademuyiwa F, Janarthanan B, Cheney RT. ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in invasive breast cancers overexpressing the ERBB2 gene. Modern pathology 2011; 24(8):1055-1059
  • Al-Agha OM, Liu W, Chandrasekhar R, Wilding G, Tan D, Alrawi S, Khoury T. CD138 (Syndecan-1) in thymic tumors: correlation with various World Health Organization types and clinical outcome. International journal of clinical and experimental pathology 2010; 3(3):280-287
  • Agrawal S, Kuvshmoff BW, Khoury T, Yu J, Javle MM, LeVea C, Groth J, Coignet LJ, Gibbs JF. CD24 expression is an independent prognostic marker in cholangiocarcinoma. Annals of surgical oncology 2007; 14(2 Suppl.):57
  • Alam N, Khoury T, Yu J, Javle M. CD 24 expression in cancer of the pancreas. Proceedings of the American Association for Cancer Research Annual Meeting 2007; 48:1039-1040
  • Azrak S, Ping L, Starostik P, Wilding G, Khoury T. Universally-Primed Quantitative Multiplex PCR Short Fluorescent Fragments (upQMPSF): A New Detection Method for HER2 Amplification in Breast Cancer. Laboratory investigation 2009; 89(Suppl. 1):28A (Abstract #113)
  • Bharthuar A, Khoury T, Haas KN, Mashtare T, Black J, Baer M, Yang G, Khushalani N, Iyer RV. Expression of breast cancer resistance protein (BCRP) in esophageal cancers (EC). Journal of clinical oncology 2009; 27(15 Suppl.):Abstract #e13529
  • Fan C, Malik D, Kulkartni S, Daoud N, Tan D, Khoury T. Modified Alcian Blue Enhances the Intraoperative Diagnosis of Sentinel Lymph Node Metastasis in Invasive Lobular Carcinoma: A Prospective Study. Laboratory investigation 2009; 89(Suppl. 1):39A (Abstract #164)
  • Feng W, Truong CD, Li W, Khoury T, Alrawi S, Xia K, Yao J, Tan D. Thyroid transcription factor 1 is not expressed in gastric adenocarcinoma: A study of 220 cases. Laboratory investigation 2008; 88(Suppl. 1):536
  • Khoury T, Argawal S, Yu J, Gibbs JF, Brattain MG, Javle MM, Kuvshinoff B, Zakharia Y, Hicks DG. CD24 expression predicts poor outcome in cholangiocarcinoma. Laboratory investigation 2007; 87(Suppl. 1):1300
  • Khoury T, Arshad A, Arnouk M, Tan D. D2-40, mesothelin, podoplanin and other mesothelioma-related markers in thymic tumors: A tissue Microarray analysis of 57 cases. Laboratory investigation 2008; 88(Suppl. 1):344A (Abstract #1569)
  • Khoury T, Arshad A, Arshad M, Arnouk M, Alrawi S, Tan D. Thymoma: Immunohistochemistry study with emphasis on lymphoid markers (CD57, CD20, CD3, and CD5) and clinicopathologic correlation. Laboratory investigation 2008; 88(Suppl. 1):260A (Abstract #1189)
  • Khoury T, Sait S, Wilding G, Chandrasekhar R, Daoud N, Kulkarni S. Delayed Formalin Fixation Effect on Breast Biomarkers. Laboratory investigation 2009; 89(Suppl. 1):50A (Abstract #215)
  • Khoury T, Wilding G, Chandrasekhar R, Alrawi S, Tan D. A Panel of Immunohistochemistry To Differentiate Various WHO Types of Thymic Neoplasms. Laboratory investigation 2009; 89(Suppl. 1):355A (Abstract #1609)
  • Khoury T, Yang J, Ramnath N, Zakharia Y, Zhang S. Cytoplasmic and nuclear expressions of survivin predict worse outcome of thymic neoplasms. Laboratory investigation 2007; 87(Suppl. 1):1493
  • Maddipatla S, Khoury T, Gibbs JF, Nasser E, Rutledge P, Iwata K, Black J, Javle M. Epithelial-mesenchymal transition (EMT) and role of p-Erk in surgically resected pancreatic cancer. Annals of surgical oncology 2007; 14(2 Suppl.):4
  • Seitz RS, Ross DT, Ring BZ, Beck RA, Khoury T, Vardarajan R, Iqbal J, Kulkarni S, Janarthanan BR, Hicks DG. Validation of an immunohistochemical biomarker for identifying Her2+patients at high risk of recurrence. Breast cancer research and treatment 2007; 106(Suppl. 1):S248
  • Truong CD, Feng W, Li W, Khoury T, Alwari S, Xia K, Yao J, Tan D. Characteristics of Epstein-Barr Virus-associated gastric cancer: 20-year experience in a single medical center. Laboratory investigation 2008; 88(Suppl. 1):625
  • Truong CD, Li W, Feng W, Cagle P, Khoury T, Alrawi S, Xia K, Yao J, Tan D. Alpha-Methylacyl-CoA racemase (AMACR) is upregulated in gastric cancer: A study of 220 cases. Laboratory investigation 2008; 88(Suppl. 1):624
  • Vinjamaram S, Gibbs J, Khoury T, Repasky E, Hylander B, Iyer R. In vivo translational drug development model in pancreatic cancer. American journal of gastroenterology 2008; 103(Suppl. 1):S84 (Abstract #218)
  • Zhang S, Yang J, Rammath N, Zakharia T, Khoury T. The prognostic value of p53 and Ki-67 expression in thymic neoplasm: A clinicopathological and immunohistochemical study of 60 thymic tumors. Laboratory investigation 2007; 87(Suppl. 1):1545
  • Dhingra S, Feng W, Brown RE, Zhou Z, Khoury T, Zhang R, Tan D. Clinicopathologic significance of putative stem cell markers, CD44 and nestin, in gastric adenocarcinoma. International journal of clinical and experimental pathology 2011; 4(8):733-741
  • Habib F, Syriac S, Wang D, Liu S, Karabakhtsian R, Tan D, Khoury T. High Grade Lobular Carcinoma In Situ in Breast Excision: Potential for Misdiagnosis as Solid Type DCIS or Classical LCIS. Laboratory investigation 2012; 92(Suppl. 1):42A
  • Khoury T, Ademuyiwa FO, Chandraseekhar R, Jabbour M, Deleo A, Ferrone S, Wang Y, Wang X. Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy. Modern pathology 2012; 25(3):388-397
  • Augoff K, Zhang L, Rivera L, Khoury T, Tian L, Groman A, Watroba N, Plow EF, Kulkarni S, Sossey-Alaoui K. Increased expression levels of WAVE3 are associated with breast cancer progression and metastasis. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #3206
  • Ademuyiwa FO, Khoury T, Warner J, Gannon J, Hwang H. An 81-year-old patient with distant metastasis of invasive lobular carcinoma occurring 41 years after mastectomy. Clinical breast cancer 2012; 12(4):293-295
  • Herko A, Pophali P, Wallace PK, Sharma P, Loud P, Khoury T, Battiwalla M. T-cell large granular lymphocytosis associated with malignant thymoma. Leukemia research 2012; 36(8):e187-e189
  • Monhollen L, Morrison C, Ademuyiwa FO, Chandrasekhar R, Khoury T. Pleomorphic lobular carcinoma: a distinctive clinical and molecular breast cancer type. Histopathology 2012; 61(3):365-377
  • Francescutti V, Khoury T, Kulkarni S. Foreign body reaction mimicking breast carcinoma in patient with stage IV ovarian cancer. Breast journal 2012; 18(5):490-491
  • Kulkarni S, Augoff K, Rivera L, McCue B, Khoury T, Groman A, Zhang L, Tian L, Sossey-Alaoui K. Increased expression levels of WAVE3 are associated with the progression and metastasis of Triple Negative Breast Cancer. PloS one 2012; 7(8):e42895
Source URL (retrieved on 05/19/2013 - 5:11am): http://www.roswellpark.org/thaer-khoury