Title European Ewing Tumor Working Initiative of National Groups Ewing Tumor Studies 1999
Principal Investigator Martin Brecher, MD
Study Number 25104
Summary In patients with isolated pulmonary or pleural metastases at the initial diagnosis of Ewing sarcoma (R2 pulm) to compare event free (EFS) and overall survival (OS) in a randomized study of vincristine-actinomycin D-ifosfamide consolidation combined with whole lung irradiation vs. megatherapy using busulfan -melphalan conditioning followed by stem cell infusion.
- Patients must be less than 50 years old at time of study enrollment with isolated pulmonary or pleural metastases at the initial diagnosis of Ewing sarcoma
- No previous chemotherapy
- Adequate renal and cardiac function