Research & Education
Cancer Can't Win
MM-121 is a material called an anti-ErbB3 human monoclonal antibody. A monoclonal antibody is a type of protein made in the laboratory. Starting with an actual cell, duplicate antibody proteins are made to be exactly like the original ("monoclonal"). An antibody is a type of protein that is made in the body in response to a foreign substance. Antibodies can locate and bind to substances in the body, including tumor cells. MM-121 is an antibody that binds to a specific protein found on the surface of the cells. This protein, ErbB3, is involved with cell growth. In laboratory studies, MM-121 has been shown to bind to ErbB3 and hinder tumor cell growth. This study is going to look at the effects in humans.
In this study, MM-121 will be used in combination with a FDA approved drug called erlotinib (Tarceva). Erlotinib is approved for the treatment of non-small cell lung cancer, but not in combination with another treatment. In laboratory studies, the combination of MM-121 and erlotinib was shown to be more effective at reducing tumor size than using either drug by itself.