Title Genetic Signature for Progression of Barrett's Esophagus to Esophageal Adenocarcinoma. A Pilot Study
Principal Investigator Michael Schiff, MD
Study Number 170810
Summary This is a research study that will look at genetic information in tissue to help find out more information about Barrett's esophagus and the development of dysplasia (pre-cancer) and esophageal cancer arising from within the Barett's esophagus. This is a disease that is increasing in frequency. Barrett's esophagus is a condition where the superficial lining of the esophagus changes and is associated with higher risk of developing cancer of the esophagus. Presently patients with Barrett's esophagus require surveillance endoscopies and biopsies on a regular basis. Only some patients however progress to cancer and it is unclear what differentiates those who progress to cancer from those that do not. This study is aimed at finding markers in the tissues to help identify patients more or less likely to progress. Esophageal adenocarinoma (EAC), a lethal cancer with very high mortality rates, is increasing alarmingly in incidence and results from dysplastic progression of Barrett's esophagus (BE). Patients with BE have a 30-125 increased risk of developing EAC compared to the general population.
- Patients undergoing upper GI (EGD) for BE surveillance
- Patients undergoing endoscopy for evaluation and/or treatment of HGD arising from a BE
- Patients undergoing evaluation and/or treatment for EAC arising from a BE
- Patients referred for another endoscopy at a later date may be entered into the study repeatedly