Exploring Current Smokers' Interest in Using Smokeless Tobacco Products Smokeless Tobacco Substitution for Cigarettes

Title Exploring Current Smokers' Interest in Using Smokeless Tobacco Products Smokeless Tobacco Substitution for Cigarettes
Principal Investigator Martin Mahoney, MD PhD
Study Number 165309
Phase1
Summary The research is concerned with the potential for forms of nicotine delivery, other than cigarettes, to speed up the elimination of cigarette smoking. It is well known that short term use of nicotine in the form of Nicotine Replacement therapy or NRT (e.g., gum, patches) can help smokers to quit. It is now known that a small percentage of those who use NRT to quit continue to use it long term. Some say they do so because they are now addicted to NRT, while others say they need to use the NRT to keep from relapsing to smoking. We know that long term use of NRT is much less harmful than smoking. Should we be encouraging those who could not quit altogether to continue using NRT? If we did, how many more smokers might adopt it as a strategy to avoid relapsing back to smoking? `New smokeless tobacco products modeled on pasteurized Swedish snus, are now available in the US market.  These products have been marketed by manufacturers and differ from the snuff and chew products traditionally sold and used in the US and appear to have lower levels of cancer causing chemicals.  Compressed tobacco lozenges have also been made available, and also appear low in cancer causing by-products.  Most of these products are marketed to smokers, but little is known about smokers' interest in using smokeless products as temporary substitute for cigarette smoking or willingness to switch over completely from cigarettes to smokeless tobacco.
Eligibility
  • Must be at least 18 years of age
  • Must currently smoke at least 10 cigarettes per day and been smoking for at least 1 year
  • Must not be planning to quit smoking in the next 30 days, nor tried to quit in the last 30 days
  • Must be able to read and speak English
  • Should not concurrently using other tobacco products or nicotine medications
  • Must be in good general health
  • Medically eligible to receive nicotine replacement products
  • No history of heart attack or stroke in last 2 weeks
  • No current use of Zyban, bupropion, Wellbutrin or Chantix or other smoking cessation medication
  • No history of chest pains in past month
  • No report of physician diagnosed arrhythmia/irregular heart beat or use of pacemaker
  • No report of physician diagnosed heart disease/coronary artery disease, untreated hypertension, stomach ulcer, diabetes, depression or asthma
  • No report of dental work, teeth or jaw problems such as TMJ
  • For females, not currently pregnant or breastfeeding; nor planning to become pregnant during the follow-up interval.