Anurag Singh, MD

Wong RKW, Zhang Q, Sagar S, Wyatt G, Nguyen-Tan PF, Singh AK, Lukaszczyk B, Cardinale F, Yeh AM, Ang KK. Phase II Results of RTOG 0537: A Phase II/III Study Comparing Acupuncture-like Transcutaneous Electrical Nerve Stimulation Versus Pilocarpine in Treating Early Radiation-Induced Xerostomia. Accepted Cancer October 2011.

*Martin KL, Gomez J, Nazareth DP, Warren GW, Singh AK. Quantification of Incidental Mediastinal and Hilar Irraditiation Delivered During Definitive Stereotactic Body Radiation Therapy for Peripheral Non-Small Cell Lung Cancer. Accepted Med Dosim June 2011.

*Krieger A, Iordachita I, Guion P, Singh AK, Kaushal A, Menard C, Pinto PA, Fichtinger G, Whitcomb LL. A MRI-Compatible Robotic System with Hybrid Tracking for MRI-Guided Prostate Intervention. IEEE Trans Biomed Engineering. (58) In Press 2011.

*Platek ME, Reid ME, Wilding GE, Jaggernauth W, Rigual NR, Hicks WL, Popat SR, Warren GW, Sullivan M, Thorstad WL, Loree TR, Singh AK. Pretreatment nutritional status of head and neck cancer patients receiving definitive concurrent chemoradiation therapy predicts recurrence. Accepted H&N September 2010.

Sen A, Capitano ML, Spernyak JA, Schoeckler JT, Thomas S, Singh AK, Evans SS, Hylander B, Repasky E. Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia, and enhances the efficacy of radiotherapy in murine tumor models. Cancer Research. 71(11):3872-80. 2011.

*Platek ME, Merzianu M, Mashtare TL, Popat SR, Rigual NR, Warren GW, Singh AK. Improved Survival Following Surgery and Radiation Therapy for Olfactory Neuroblastoma: Analysis of the SEER Database. Radiation Oncology 6: 41. 2011.

Schildkraut JS, Prosser N, Savakis A, Gomez J, Nazareth D, Singh AK, Malhotra HK. Level Set Segmentation of Pulmonary Nodules in Megavolt Electronic Portal Images using a CT Prior. Med Phys. 37(11):5703-1. 2010.

Singh AK, Mashtare TL, *McCloskey SA, *Mikelus S, Kim HL, *Salerno KS. Increasing age and treatment modality are predictors for subsequent diagnosis of bladder cancer following prostate cancer diagnosis. Int J Radiat Oncol Biol Phys 78(4):1086-94. 2010.

Van Waes C, Allen C, Citrin D, Gius D, Colevas AD, Harold N, Rudy S, Muir C, Chen Z, Singh AK, Albert P, Dancy J, Morris JC. Molecular and Clinical Responses to Gefitinib Combined with Paclitaxel and Radiation in Patients with Locally Advanced Head and Neck Cancers from a Pilot Phase I Clinical Study. Int J Radiat Oncol Biol Phys. 77(2):447-54. 2010.

Singh AK, Chen J, Calado R, Sowers A, Mitchell JB, Barrett AJ. Total Body Irradiation With Lung Dose-Reduction Does Not Improve Hematopoietic Cell Homing to Bone Marrow During Allogeneic Transplantation. Bone Marrow Transplant. 45(1):25-30. 2010.

*McCloskey SA, Jaggernauth W, Schwarz JK, Mashtare TL, Khan MK, Hicks WL, Popat SR, Rigual NR, Loree TR, Singh AK. Radiation Treatment Interruptions Greater than 1 week and Low Hemoglobin Levels (12 gm/dl) are Predictors of Local Regional Failure Following Definitive Concurrent Chemotherapy and IMRT for Squamous Cell Carcinoma of the Head and Neck. Am Jn of Clin Oncol. 32(6):587-9. 2009.

Tchabo, NE, McCloskey SA, Mhawech-Fauceglia P, Mashtare TL, Andrews C, Singh AK, Odunski K, Lele S, Jaggernauth W. Treatment of early stage uterine papillary serous carcinoma at Roswell Park Cancer Institute, 1992-2006. Gyn Onc. 115(2):249-56. 2009.

*Simone NL, Singh AK, Cowan JE, *Soule BP, Carroll PR, Litwin MS. Pre-treatment Predictors of Death From Other Causes in Men With Prostate Cancer. J Urol. 180(6): 2447-51. 2008.

Xu S, Kruecker J, Turkbey B, Glossop N, Singh AK, Choyke P, Pinto P, Wood BJ. Real-time MRI-TRUS Fusion for Targeted Prostate Biopsy Guidance. Comput Aided Surgery. 13(5): 255-64. 2008.

*Sharp H, Morris JC, VanWaes C, Gius D, Karimpour SE, Cooley-Zgela T, Singh AK. High Incidence of Oral Dysesthesias on a Trial of Gefitinib, Paclitaxel and Concurrent External Beam Radiation for Locally Advanced Head and Neck Cancers. Am Jn of Clin Oncol. 31: 557-560. 2008.

Singh AK. Editorial comment on: contrast-enhanced ultrasound and prostate cancer; a multicentre European research coordination project. Eur Urol. 54(5): 993. 2008.

Esthappan J, Chaudhari S, Santanam L, Mutic S, Olsen J, MacDonald D, Low DA, Singh AK, Grigsby PW. Prospective Clinical Trial of PET/CT Image-guided IMRT for Cervical Carcinoma with Positive Para-aortic Lymph Nodes. Int J Radiat Oncol Biol Phys 72(4): 1134-1139. 2008.

Singh AK, Kreucker J, Xu S, Glossop N, Guion P, Ullman K, Choyke PL, Wood BJ. Initial Clinical Experience with real time ultrasound-MRI fusion guided prostate biopsy. BJU Int 101(7):841-5. 2008.

Singh AK, *Krieger A, *Latouf JB, Guion P, Grubb RL, Albert PS, Metzger G, Ullman K, Smith S, Fichtinger G, Ocak I, Choyke P, Ménard C, Coleman J. Patient selection determines prostate cancer yield of dynamic contrast enhanced, MRI-guided trans-rectal biopsies in a closed 3 Tesla Scanner. BJU Int 101(2):181-5. 2008.

*Simone NL, *Soule BP, Ménard C, Guion P, Smith S, Crouse NS, Godette DJ, Cooley-Zgela T, Sciuto LC, Albert PS, Camphausen K, Coleman CN, Singh AK. Intrarectal Amifostine During External Beam Radiation Therapy for Prostate Cancer Produces Significant Improvements in Acute and Late Rectal Toxicity Measured by EPIC Score. Int J Radiat Oncol Biol Phys 70(1):90-5. 2008.

*Mishra MV, Singh AK. A Second Transient Prostate-Specific Antigen Elevation Following External Beam Radiation Therapy and Fractionated MRI Guided High Dose Rate Brachytherapy Boost: Case Report and Review of the Literature. Clinical Genitourinary Cancer 5(6):406-8. 2007.

Savani BN, Donohue T, Kozanas E, Shenoy A, Singh AK, Childs RW, Barrett AJ. Absolute lymphocyte count on day 30 is strongly predictive for outcome after T-cell depleted allogeneic stem cell transplantation for hematological malignancy. Biol of Blood and Marrow Transplant (10):1216-23. 2007.

Singh AK, Guion P, Crouse NS, Ullman K, Smith S, Albert PS, Fichtinger G, Choyke PL, Xu S, Kruecker J, Wood BJ, Krieger A, Ning H. Simultaneous Integrated Boost of Biopsy Proven, MRI Defined Dominant Intra-prostatic Lesions to 95 Gray with IMRT: Early Results of a Phase I NCI Study. Radiation Oncology 2(36). 2007.

*Soule BP, *Simone NL, Savani B, Ning H, Albert PS, Barrett AJ, Singh AK. Pulmonary function following total body irradiation (with or without lung shielding) and allogeneic peripheral blood stem cell transplant. Bone Marrow Transplant. 40(6):573-8. 2007.

*Savani BN, Donohue T, Kozanas E, Shenoy A, Singh AK, Childs RW, Barrett AJ. Increased Risk of Bone Loss Without Fracture Risk in Long Term Survivors After Allogeneic Stem Cell Transplantation. Biol of Blood and Marrow Transplant. 13(5) 517-520. 2007.

*Lattouf JB, Grubb RL, Lee JM, Bjurlin M, Albert PS, Singh AK, *Ocak I, Choyke P, Coleman J. Yield of MRI Directed Trans-rectal Ultrasound Biopsies of the Prostate in Patients at High Risk of Having Prostate Cancer. BJU Int. 99(5): 1041-6. 2007.

Singh AK, *Savani BN, Albert PS, Barrett AJ. Efficacy of CD34 Positive Stem Cell Dose In Patients Undergoing Allogeneic Peripheral Blood Stem Cell Transplant May Differ With Presence of Lung Dose Reduced Total Body Irradiation. Biol of Blood and Marrow Transplant. 13(3). 339-44. 2007.

Krieger A, Csoma C, Iordachital II, Guion P, Singh AK, Fichtinger G, Whitcomb LL. Design and preliminary accuracy studies of an MRI-guided transrectal prostate intervention system. Med Image Comput Comput Assist Interv.10(Pt 2):59-67. 2007.

Xu S, Kruecker J, Guion P, Glossop N, Neeman Z, Choyke P, Singh AK, Wood BJ. Closed-loop control in TRUS-guided prostate biopsy. MICCAI 2007. LNCS, vol. 4791, pp. 128–135. Springer, Heidelberg (2007).

Singh AK, Karimpour SE, *Savani BN, Guion P, *Hope AJ, *Mansueti JR, Ning H, Altemus RM, Wu CO, Barrett AJ. Pretransplant Pulmonary Function Tests Predict Risk of Mortality Following Fractionated Total Body Irradiation and Allogeneic Peripheral Blood Stem Cell Transplant. Int J Radiat Oncol Biol Phys. 66(2). 520-7. 2006.

Singh AK, *Tierney RM, Low DA, *Parikh PJ, Myerson RJ, Deasey JO, *Wu CS, Pereira GC, *Wahab S, Mutic S, Grigsby PW, *Hope AJ. A Prospective Study of Duodenum and Small Bowel Motion Between Radiation Treatments: Implications for Conformal Radiation Therapy. Radiation Oncology 1(32).1-5. 2006.

Singh AK, Guion P, Susil RC, Citrin DE, Ning H, Miller RW, Ullman K, Smith S, Crouse NS, Godette DJ, *Stall BR, Coleman CN, Camphausen K, Menard C. Early Observed Transient Prostate-Specific Antigen Elevations On a Pilot Study of External Beam Radiation Therapy and Fractionated MRI Guided High Dose Rate Brachytherapy Boost. Radiation Oncology 1(28). 1-5. 2006.

Savani BN, Montero A, Srinivasan R, Singh A, Shenoy A, Mielke S, Rezvani R, Karimpour SE, Childs R, Barrett AJ. Chronic GVHD and pre-transplant pulmonary damage are the main determinants of pulmonary function defects 5 years or more after stem cell transplantation. Biol of Blood and Marrow Transplantation. (12) 1261-1269. 2006.

*Anders JC, Grigsby PW, Singh AK. Cisplatin Chemotherapy (Without Erythropoietin) and Risk of Life-Threatening Thromboembolic Events In Carcinoma of The Uterine Cervix: The Tip of the Iceberg? A Review of the Literature. Radiation Oncology. 1 (1) 14: 1-5. 2006.

Singh AK, Ménard C, Guion P, *Simone NL, Smith S, Crouse NS, Godette DJ, Cooley-Zgela T, Sciuto LC, Coleman J, Pinto P, Albert PS, Camphausen K, Coleman CN. Intrarectal Amifostine Suspension May Protect Against Acute Proctitis During Radiation Therapy for Prostate Cancer: A Pilot Study. Int J Radiat Oncol Biol Phys, 65(4): 1008-1013, 2006.

*Brown MW and Singh AK. Alkaline Phosphatase Rise With Initiation of Hormone Therapy For Prostate Cancer Portends Poor Prognosis With Rapid Progression To Bone Metastases: A Case Report and Review of the Literature. Clinical Genitourinary Cancer. Vol 4 (4): 293-5, 2006.

Myerson RJ, Singh AK, Bigott H, Englebach J, Kim J, Lamoreaux WT, Moros EG, Novak P, Sharp T, Straube WL, Welch MJ, Xu M. Monitoring the Effect of Mild Hyperthermia on Tumor Hypoxia by Cu-ATSM PET Scanning. Int. J Hyperthermia, 22, 93-116, 2006.

Novak P, Moros EG, Parry JJ, Rogers BE, Myerson RJ, *Zeug A, Locke JE, Rossin R, Welch MJ, Straube WL, Singh AK. Experience with a Small Animal Hyperthermia Ultrasound System (SAHUS): Report on 83 Tumors. Biology, Physics and Medicine. 50(21): 5127-39, 2005.

Cengiz M, Singh AK, Grigsby PW. Postoperative Vaginal Brachytherapy Alone is the Treatment of Choice for Grade 1-2, Stage IC Endometrial Cancer. Int J Gyn Cancer (15) 921-926. 2005.

Locke J, Zeug A, Thompson D Jr, Allan J, Mazzeralla K, Novak P, Hanson D, Singh AK, Moros EG, Pandita TK. Localized versus regional hyperthermia: Comparison of xenotransplants treated with a small ultrasound system and waterbath limb immersion. Int J Hyperthermia, 21(3): 271-81. 2005.

Lu W, Parikh PJ, El Naqa I, Nystrom M, Hubenschmidt J, Wahab S, Singh AK, Christensen G, Mutic S, Bradley J, Low D. Quantitation of the four-dimensional computed tomography process. Medical Physics 32(4): 890-901. 2005.

Jagsi R, Buck DA, Singh AK, Engelman M, Thakkar V, Frank S. Results of the 2003 Association of Residents in Radiation Oncology (ARRO) Survey. Int J Radiat Oncol Biol Phys 61(3): 642-8. 2005.

Singh AK, Grigsby PW, Rader JS, Mutch DG, Powell MA. Cervical Carcinoma, Concurrent Chemoradiation & Salvage of Isolated Para-aortic Lymph Node Recurrences. Int J Radiat Oncol Biol Phys, 61(2): 450-5. 2005.

Grigsby PW, Singh AK, Rader JS, Siegel BA, Zoberi IZ. Lymph Node Control in Carcinoma of the Cervix. Int J Radiat Oncol Biol Phys, 59(3): 706-12. 2004.

Crane CH, Phan T, Skibber J, Janjan N, Singh AK, Birnbaum EH, Fleshman JW, Kodner IJ, Lockett MA, Picus J, Lin EH, Read TE, and Myerson RJ. The Addition of Continuous Infusion 5-FU to Preoperative Radiotherapy Increases Response, Sphincter Preservation, and Overall Survival in Locally Advanced Rectal Cancer. Int J Radiat Oncol Biol Phys, 57(1):84-9. 2003.

Singh AK, Moros EG, Novak P, Straube WE, Locke JE, Zeug A, Myerson RJ. A Micro-PET Compatible, Small Animal Hyperthermia Ultrasound System (SAHUS) for Sustainable, Collimated and Controlled Hyperthermia of Subcutaneously Implanted Tumors. Int J Hyperthermia, 20(1) 32-44. 2003.

Singh AK, Grigsby PW, Siegel BA, Dehdashti F. FDG-PET Lymph Node Staging and Survival of Patients with FIGO Stage IIIB Cervical Carcinoma. Int J Radiat Oncol Biol Phys, 56(2): 489–493, 2003.

Singh AK, Lockett MA, Bradley JD. Analysis of Clinical and Dosimetric Predictors of Radiation-Induced Esophageal Toxicity in Patients with Non Small Cell Lung Cancer Treated With Three Dimensional Conformal Radiation Therapy. Int J Radiat Oncol Biol Phys, 55(2): 337-341. 2003.

Myerson RJ, Singh A, Birnbaum E, Fleshman J, Fry R, Kodner I, Lockett M, Picus J, Walz B, Read T. Pre Treatment Clinical Findings Predict Outcome For Patients Receiving Preoperative Radiation For Rectal Cancer. Int J Radiat Oncol Biol Phys, 50(3): 665-74. 2001.

Singh AK, Myerson RJ, Kodner IJ, Read TA, Fleshman JW, Birnbaum EH. Outcome of Patients with Rectal Adenocarcinoma and Localized Pelvic Non-Nodal Metastatic Foci. Diseases of Colon and Rectum, 43(9): 1217-21. 2000.

Kreucker J, Xu S, Glossop N, Guion P, Choyke P, Singh AK, Wood BJ. Fusion of real-time transrectal ultrasound with pre-acquired MRI for multi-modality prostate imaging. Proc of SPIE (8752) February 12-17 2007, 912-923.

Low DA, Parikh PJ, El Naqa IM, Nystrom MM, Lu W, Hubenschmidt JP, Wahab SH, Mutic S, Singh AK, Christensen G, and Bradley JD. Quantitative 4-D CT using a multislice CT scanner, Proceedings of the 14th International Conference on the Use of Computers in Radiation Therapy, Seoul, Korea, May 9-14, 2004, 57-61.

El Naqa IM, Low DA, Christensen G, Parikh PJ, Song JH, Nystrom M, Lu W, Deasey JO, Hubenschmidt J, Wahab S, Mutic S, Singh AK, Bradley JD. Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, Proc of SPIE (5369), San Diego CA, Feb 15-17 2004, 100-106.

Research Projects:

09/2009 -- Present

Radiation therapy Oncology Group (RTOG) A Randomized Phase II Study, A Randomized Phase II Study Comparing 2 Sterotactic Body Radiation Therapy (SBRT) Schedules for Medically Inoperable Patients with Stage I, Peripheral Non-Small Cell Lung Cancer (34 Gy x 1 vs 12 Gy x 4) (co-PI with G. Videtic and J. Chang)

11/2008 -- Present

RPCI-A feasibility of study of re-irradiation using SBRT, A feasibility of study of re-irradiation using stereotactic body radiation therapy (SBRT) and concurrent cisplatin, fluorouracil, and cetuximab for recurrent squamous cell carcinoma of the head and neck (SCCHN)

04/2008 -- Present

RPCI- A Phase II Randomized Study of 2 SBRT Regimens, A Phase II Randomized Study of 2 Sterotactic Body Radiation Therapy (SBRT) Regimens for Medically Inoperable Patients with Node Negative, Peripheral Non-Small Cell Lung Cancer (30 Gy x 1 vs 20 Gy x 3)

09/2007 -- Present

RPCI MR Imaging to Stratify Prostate Cancer Progression Risk, MR Imaging to Stratify Prostate Cancer Progression Risk in Patients On Active Surveillance

09/2005 -- Present

NCI-A Pilot Study of Image Guided Prostate and Pelvic Irradiation, National Cancer Institute (NCI) - A Pilot Study of Image Guided Prostate and Pelvic Nodal Irradiation with Intensity Modulated Radiation Therapy (IMRT) (Current PI: A Kaushal)

05/2005 -- Present

NCI-A Phase I Study of Image Guided Dose Escalation with IMRT, National Cancer Institute (NCI) A Phase 1 Study of Image Guided Dose Escalation with Intensity Modulated Radiation Therapy (IMRT) to Histologically Confirmed Regions of Prostate Cancer (Current PI: A Kaushal)

06/2003 -- Present

Wash.Univ.- A Phase II study of extended field external beam irradiation, Washington University, Saint Louis - A Phase II study of extended field external beam irradiation and intracavitary brachytherapy with concurrent weekly cisplatin in patients with stage 1-IV a cervical cancer who have FDG-PET positive pelvic or para-aortic nodes (Current PI: P Grigsby)

Grants:

A Phase 2 Placebo-Controlled Randomized Study of the Effect of Samital on Incidence, Duration and Severity of Oropharyngeal Mucositis Induced by Chemoradiation for Squamous Cell Carcinoma of the Head and Neck (SCCHN), Indena SPA, Principal Investigator, $1,186,478, 12/2010 -- 12/2015, Active

Hybrid Imaging Technique (HIT) Guided Biopsy to Map Prostatic Adenocarcinoma in Patients Undergoing Prostatectomy, Roswell Park Alliance Foundation, Co-Investigator, $99,956, 07/2009 -- 12/2011, Active

A Phase II Randomized Study of 2 Sterotactic Body Radiation Therapy (SBRT) Regimens for Medically Inoperable Patients with Node Negative, Peripheral Non-Small Cell Lung Cancer, Roswell Park Alliance Foundation, Co-Investigator, $97,963, 04/2008 -- 06/2012, Active

MR Imaging to Stratify Prostate Cancer Progression Risk in Patients on Active Surveillance, Roswell Park Alliance Foundation, Principal Investigator, $100,000, 09/2007 Present, Active

Development of Prostate and Breast Cancer magnetic Resonance Imaging and Image Guided Therapy, Center for Clinical Research, NCI Intramural Grant, Principal Investigator, $280,000, 07/2005 -- 07/2007, Complete