Anurag Singh, MD

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Professor of Oncology
Director of Clinical Radiation Research
Director of Radiation Oncology Residency Program
Department of Radiation Medicine
Roswell Park Cancer Institute
Professor of Medicine
School of Medicine and Biomedical Sciences, State University of New York at Buffalo

Profile

Areas of Expertise: 
Breast cancer
Head and neck cancer
Lung cancer
Prostate cancer

Research

Research Interests: 
SBRT (Stereotactic Body Radiation Therapy)
Novel agents to improve radiation therapy
Novel agents to protect against side effects of radiation therapy
Development and implementation of imaging to improve radiation targeting
Methods to improve quality of life following radiation therapy
Impact of nutrition on patient outcomes

Background Information

Education and Training: 
MD - Washington University School of Medicine, St. Louis, MO
BS - Yale University
Residency: 
Mallinckrodt Institute of Radiology, St. Louis, MO
Professional Experience: 
07/2007 - Present: Associate Professor, Director of Radiation Medicine Residency Program, Director of Radiation Research, Roswell Park Cancer Institute, University at Buffalo
07/2004 - 06/2007: Attending Physician, Head of Molecular Imaging Section, Radiation Oncology Branch, National Cancer Institute
Board Certification: 
Radiation Oncology, American Board of Radiology
Honors and Awards: 
02/2011 Outstanding Accreditation Award from University at Buffalo, No citations and Commendable Practice ACGME Residency Program Review
06/2010 Educator of the Year (2009-2010), Association of Residents In Radiation Oncology (ARRO)
01/2006 CaPSure Mentor (for Nicole SImone)
05/1995 Magna Cum Laude Graduate, Yale University
01/1995 MENSA Research and Education Scholarship
01/1994 MENSA Research and Education Scholarship
01/1994 Xerox Technical Merit Scholarship

Publications

Publications: 
  • Singh AK, Chen J, Calado R, Sowers A, Mitchell JB, Barrett AJ. TBI with lung dose reduction does not improve hematopoietic cell homing to BM during allogeneic transplantation. Bone marrow transplantation 2010; 45(1):25-30
  • Warren GW, Singh A, Randall M, McGarry R, Kudrimoti M, Rangnekar V. Prognostication using Hif-1 alpha may require simultaneous nicotine assessment. Proceedings of the American Association for Cancer Research Annual Meeting 2010; 51:906
  • Fung-Kee-Fung SD , Hales L , Warren GW , Singh AK. Volumetric intensity modulated arc therapy vs. conventional IMRT in advanced head and neck cancer: a prospective, comparative dosimetric study using multiple organs at risk. International journal of radiation oncology, biology, physics 2010; 78(3 Suppl. 1):S439
  • Martin KL , Gomez J , Nazareth DP , Warren GW , Singh AK. Substantial dose is incidentally delivered to mediastinal and hilar nodes during stereotactic body radiation therapy for peripheral NSCLCA. International journal of radiation oncology, biology, physics 2010; 78(3 Suppl. 1):S512
  • May KS , Miller A , Fung-Kee-Fung SD , Singh AK. Salivary infiltrating ductal carcinoma: SEER database analysis of the impact of surgery, radiation, and lymph node involvement on survival. International journal of radiation oncology, biology, physics 2010; 78(3 Suppl. 1):S457
  • Schildkraut JS , Prosser N , Savakis A , Gomez J , Nazareth D , Singh AK , Malhotra HK. Level-set segmentation of pulmonary nodules in megavolt electronic portal images using a CT prior. Medical physics 2010; 37(11):5703-5710
  • Singh AK , Mashtare TL , McCloskey SA , Seixas-Mikelus SA , Kim HL , May KS. Increasing age and treatment modality are predictors for subsequent diagnosis of bladder cancer following prostate cancer diagnosis. International journal of radiation oncology, biology, physics 2010; 78(4):1086-1094
  • Wong RK , Yeh AM , Cardinale F , Lukaszczyk B , Singh AK , Nguyen-Tan PF , Wyatt G , Sagar S , James JL , Berk L. RTOG 0537 phase II/III study comparing acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) versus pilocarpine in treating early radiation-induced xerostomia (RIX): phase II results. International journal of radiation oncology, biology, physics 2010; 78(3 Suppl. 1):S79-S80
  • McCloskey SA, Loree TR, Khan MK, Mashtare TL, Sullivan M, Popat SR, Hicks WL, Rigual NR, Jaggernauth W, Singh AK. Radiation treatment interruptions greater than one week and low hemoglobin levels (12 g/dL) are predictors of local regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck. American journal of clinical oncology 2009; 32(6):587-591
  • Tchabo NE, McCloskey S, Mashtare TL, Andrews C, Singh AK, Mhawech-Fauceglia P, Odunsi K, Lele S, Jaggernauth W. Treatment of early-stage uterine papillary serous carcinoma at Roswell Park Cancer Institute, 1992-2006. Gynecologic oncology 2009; 115(2):249-256
  • Martin KL, Gomez J, Nazereth DP, Warren GW, Singh AK. Substantial incidental mediastinal and hilar irradiation is delivered during definitive stereotactic body radiation therapy for peripheral non-small cell lung cancer. Journal of thoracic oncology 2010; 5(12 Suppl. 7):S519
  • Platek ME, Merzianu M, Mashtare TL, Popat SR, Rigual NR, Warren GW, Singh AK. Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database. Radiation oncology (London, England) 2011; 6:41
  • Sen A, Capitano ML, Spernyak JA, Schueckler JT, Thomas S, Singh AK, Evans SS, Hylander BL, Repasky EA. Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer research 2011; 71(11):3872-3880
  • Sharp H, Morris JC, Van Waes C, Gius D, Cooley-Zgela T, Singh AK. High incidence of oral dysesthesias on a trial of gefitinib, Paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers. American journal of clinical oncology 2008; 31(6):557-560
  • Simone NL, Singh AK, Cowan JE, Soule BP, Carroll PR, Litwin MS. Pretreatment predictors of death from other causes in men with prostate cancer. Journal of urology 2008; 180(6):2447-2451; discussion 2451-2
  • Singh AK, Kruecker J, Xu S, Glossop N, Guion P, Ullman K, Choyke PL, Wood BJ. Initial clinical experience with real-time transrectal ultrasonography-magnetic resonance imaging fusion-guided prostate biopsy. BJU international 2008; 101(7):841-845
  • Singh AK, Krieger A, Wood BJ, Kruecker J, Xu S, Choyke PL, Fichtinger G, Albert PS, Smith S, Ullman K, Sears-Crouse N, Guion P, Ning H. Simultaneous integrated boost of biopsy proven, MRI defined dominant intra-prostatic lesions to 95 Gray with IMRT: early results of a phase I NCI study. Radiation oncology (London, England) 2007; 2:36
  • Housri N, Ondos J, Choyke PL, Barbara A, Ning H, Citrin D, Singh AK, Kaushal A. Tumor Nodule Location Predicts the Feasibility of Intraprostatic High-dose Irradiation in Men with Localized Prostate Cancer. International journal of radiation oncology, biology, physics 2009; 75(3 Suppl.):S143-S144
  • Jaggernauth WA, Tchabo N, Yang G, Yap J, Odunsi K, Rodabaugh K, Lele S, Singh A, Mc Closkey S. High distant failure rate despite good local control in high risk early stage endometrial cancer. International journal of radiation oncology, biology, physics 2008; 72(1 Suppl.):S366
  • McCloskey SA, Jaggernauth W, Schwarz JK, Mashtare TL, Khan MK, Hicks WL, Popat SR, Rigual NR, Loree TR, Singh AK. Radiation treatment interruptions greater than 1 week and low hemoglobin levels (12 gm/dl)) triple local regional failure following definitive concurrent chemotherapy and IMRT for squamous cell carcinoma of the head and neck. International journal of radiation oncology, biology, physics 2008; 72(1 Suppl.):S407
  • Platek ME, Mashtare TL, Popat SR, Merzianu M, Singh AK. Improved Survival following Surgery and Radiation for Olfactory Neuroblastoma: Analysis of the SEER Database. International journal of radiation oncology, biology, physics 2009; 75(3 Suppl.):S396
  • Singh AK, Mashtare TL, McCloskey SA, Seixas-Mikelus S, May KS. Following prostate cancer diagnosis, the incidence of bladder cancer increases after either surgery or irradiation, and is highest after surgery and adjuvant radiation. International journal of radiation oncology, biology, physics 2008; 72(1 Suppl.):S94
  • Krieger A, Iordachita II, Guion P, Singh AK, Kaushal A, Menard C, Pinto PA, Camphausen K, Fichtinger G, Whitcomb LL. An MRI-compatible robotic system with hybrid tracking for MRI-guided prostate intervention. IEEE transactions on bio-medical engineering 2011; 58(11):3049-3060
  • Kudrimoti MR, Arnold SM, Valentino J, Gal T, Hyland A, Singh A, Rangnekar V, Cummings KM, Marshall JR, Warren GW. The accuracy of tobacco assessment during definitive radiotherapy or chemoradiotherapy in patients with head and neck cancer : ASCO Meeting Abstracts Part 1. Journal of clinical oncology 2011; 29(15 Suppl.):1556
  • Platek ME, Reid ME, Wilding GE, Jaggernauth W, Rigual NR, Hicks WL Jr, Popat SR, Warren GW, Sullivan M, Thorstad WL, Khan MK, Loree TR, Singh AK. Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy. Head and neck 2011; 33(11):1561-1568
  • Ko CJ, Menard C, Ning H, Lita E, Smith S, Pinto P, Singh AK, Coleman C, Camphausen K, Kaushal A. Intrarectal Amifostine Suspension During External Beam Radiotherapy For Prostate Cancer May Protect Against Long-term Toxicity. International journal of radiation oncology, biology, physics 2011; 81(2 Suppl.):S443
  • Platek ME, Cruz M, Sharma N, Burke M, Popat S, Loree T, Rigual N, Hicks W, Warren G, Singh A. Impact of Percentage of Pre-Treatment Ideal Body Weight On Outcomes of Head and Neck Cancer Patients Receiving Definitive Concurrent Chemoradiation Therapy. International journal of radiation oncology, biology, physics 2011; 81(2 Suppl.):S547
  • Platek ME, Cruz M, Sharma N, Burke M, Popat S, Loree T, Rigual N, Hicks W, Warren G, Singh A. Quantification of the Effect of Treatment Duration on Local Regional Failure after Definitive Concurrent Chemotherapy and Intensity Modulated Radiation Therapy (IMRT) for Squamous Cell Carcinoma of the Head and Neck (SCCHN). International journal of radiation oncology, biology, physics 2011; 81(2 Suppl.):S542-S543
  • Esthappan J, Chaudhari S, Santanam L, Mutic S, Olsen J, MacDonald DM, Low DA, Singh AK, Grigsby PW. Prospective clinical trial of positron emission tomography/computed tomography image-guided intensity-modulated radiation therapy for cervical carcinoma with positive para-aortic lymph nodes. International journal of radiation oncology, biology, physics 2008; 72(4):1134-1139
  • Mishra MV, Singh AK. A second transient prostate-specific antigen elevation after external-beam radiation therapy and fractionated magnetic resonance imaging-guided high-dose rate brachytherapy boost. Clinical genitourinary cancer 2007; 5(6):406-408
  • Savani BN, Donohue T, Kozanas E, Shenoy A, Singh AK, Childs RW, Barrett AJ. Increased risk of bone loss without fracture risk in long-term survivors after allogeneic stem cell transplantation. Biology of blood and marrow transplantation 2007; 13(5):517-520
  • Savani BN, Mielke S, Rezvani K, Montero A, Yong AS, Wish L, Superata J, Kurlander R, Singh A, Childs R, Barrett AJ. Absolute lymphocyte count on day 30 is a surrogate for robust hematopoietic recovery and strongly predicts outcome after T cell-depleted allogeneic stem cell transplantation. Biology of blood and marrow transplantation 2007; 13(10):1216-1223
  • Simone NL, Menard C, Soule BP, Albert PS, Guion P, Smith S, Godette D, Crouse NS, Sciuto LC, Cooley-Zgela T, Camphausen K, Coleman CN, Singh AK. Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. International journal of radiation oncology, biology, physics 2008; 70(1):90-95
  • Singh AK. Editorial comment on: contrast-enhanced ultrasound and prostate cancer; a multicentre European research coordination project. European urology 2008; 54(5):993
  • Singh AK, Krieger A, Lattouf J-B, Guion P, Grubb III RL, Albert PS, Metzger G, Ullman K, Smith S, Fichtinger G, Ocak I, Choyke P, Menard C, Coleman J. Patient selection determines the prostate cancer yield of dynamic contrast-enhanced magnetic resonance imaging-guided transrectal biopsies in a closed 3-Tesla scanner. BJU international 2008; 101(2):181-185
  • Singh AK, Savani BN, Albert PS, Barrett AJ. Efficacy of CD34+ stem cell dose in patients undergoing allogeneic peripheral blood stem cell transplantation after total body irradiation. Biology of blood and marrow transplantation 2007; 13(3):339-344
  • Soule BP, Simone NL, Savani BN, Ning H, Albert PS, Barrett AJ, Singh AK. Pulmonary function following total body irradiation (with or without lung shielding) and allogeneic peripheral blood stem cell transplant. Bone marrow transplantation 2007; 40(6):573-578
  • Van Waes C, Allen CT, Citrin D, Gius D, Colevas AD, Harold NA, Rudy S, Nottingham L, Muir C, Chen Z, Singh AK, Dancey J, Morris JC. Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer. International journal of radiation oncology, biology, physics 2010; 77(2):447-454
  • Xu S, Kruecker J, Turkbey B, Glossop N, Singh AK, Choyke P, Pinto P, Wood BJ. Real-time MRI-TRUS fusion for guidance of targeted prostate biopsies. Computer aided surgery 2008; 13(5):255-264
  • Lattouf J-B, Grubb III RL, Lee SJ, Bjurlin MA, Albert P, Singh AK, Ocak I, Choyke P, Coleman JA. Magnetic resonance imaging-directed transrectal ultrasonography-guided biopsies in patients at risk of prostate cancer. BJU international 2007; 99(5):1041-1046
  • Warren GW, Singh A, Randall M, McGarry R, Kudrimoti M, Rangnekar V. Prognostication using Hif-1 alpha may require simultaneous nicotine assessment . Proceedings of the American Association for Cancer Research Annual Meeting 2010; 51:Abstract #3729
  • Warren GW, Arnold SM, Valentino JP, Gal TJ, Hyland AJ, Singh AK, Rangnekar VM, Cummings KM, Marshall JR, Kudrimoti MR. Accuracy of self-reported tobacco assessments in a head and neck cancer treatment population. Radiotherapy and oncology 2012; 103(1):45-48
  • Fung-Kee-Fung SD, Hackett R, Hales L, Warren G, Singh AK. A prospective trial of volumetric intensity-modulated arc therapy vs conventional intensity modulated radiation therapy in advanced head and neck cancer. World journal of clinical oncology 2012; 3(4):57-62
  • Martin KL, Gomez J, Nazareth DP, Warren GW, Singh AK. Quantification of incidental mediastinal and hilar irradiation delivered during definitive stereotactic body radiation therapy for peripheral non-small cell lung cancer. Medical dosimetry 2012; 37(2):182-185
  • Wong RKW, James JL, Sagar S, Wyatt G, Nguyen-Tan PF, Singh AK, Lukaszczyk B, Cardinale F, Yeh AM, Berk L. Phase 2 results from Radiation Therapy Oncology Group Study 0537: A phase 2/3 study comparing acupuncture-like transcutaneous electrical nerve stimulation versus pilocarpine in treating early radiation-induced xerostomia. Cancer 2012; 118(17):4244-4252
  • Zhu M, Need AC, Han Y, Ge D, Maia JM, Zhu Q, Heinzen EL, Cirulli ET, Pelak K, He M, Ruzzo EK, Gumbs C, Singh, A, Feng S, Shianna KV, Goldstein DB. Using ERDS to infer copy-number variants in high-coverage genomes. American journal of human genetics 2012; 91(3):408-421
  • Warren GW, Romano MA, Kudrimoti MR, Randall ME, McGarry RC, Singh AK, Rangnekar VM. Nicotinic modulation of therapeutic response in vitro and in vivo. International journal of cancer 2012; 131(11):2519-2527