Video

JANUS automated handling workstation in action:

Files

• Request for Service Form
• General reviews on chemical screening:
  • Chemical Genetics: Ligand-Based Discovery of Gene Function
  • Exploring Biology with Small Organic Molecules
• Z-factor; evaluation and validation of HTS assay
• HTS data analysis
• Some examples of screenings using variety of readouts:
  • Example #1
    Utilization of yeast two-hybrid based assay for screening for the inhibitors of Myc-Max interaction.
  • Example #2 
    Utilization of cell based p53-reporter assay for screening for the compounds reactivating p53 in tumor cells.
  • Example #3
    Isolation of the inhibitors of p53 dependent apoptosis.
  • Example #4
    Isolation of modulators of the activity of P-glycoproteins.
  • Example #5
    Utilization of biochemical assay for screening for activators of RNase L.

Links

NCGC National Chemical Genomics Center

NCGC assay validation guidelines

Pricing

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