Policy

The flowchart below illustrates the timeline of a typical chemical library screening project. It can be roughly divided into three phases: preparation, library screening, and data analysis/hit selection/pickup.

We recommend scheduling a preliminary meeting early during the planning phase of your project to discuss estimated costs and assay requirements and controls for the high throughput format. By doing this early, you will save time and cost by avoiding unnecessary and repeated experiments later on. In the Links section of this website you will find general information about chemical screenings, requirements end evaluation of readouts to be used in high throughput screening and information about statistical analysis of readouts and HTS data. This information can be very helpful at the early stage of screening project planning.

To initiate the project you will need to complete the request for service form. Completion and submission of this form via e-mail will indicate your commitment and readiness to complete the screening. Plates and reagents required for screening should be provided by the investigator (types and amounts of consumables will be discussed at preliminary meeting). All screening experiments should be scheduled (via e-mail) at least one week in advance. If you need to cancel or reschedule for another day, please, give us at least 24-hours notice (via e-mail).

Handling of library plates will be performed only by facility staff members. The process of the library plate preparation is covered by the set-up fee.

The facility will provide 0.5 ul of primary hits for verification purposes at minimal cost. Reordering the compound for follow up experiments is the responsibility of the researcher (contact us for more information).

Original screening data will be stored on the facility computers. We guarantee the confidentiality of this data. In cases where sharing of data is beneficial, such as if the project can benefit from cross-referencing the data between different screenings, or the investigator using the facility would like to obtain data about similar or related screenings, sharing of screening information is possible given the consent of all involved parties.

The rates for services provided by the Small Molecule Screening Facility are summarized in this table. All prices are estimates and can be adjusted depending on the particular procedures the project requires.

Return to SMSC Home