Mikhail Chernov, PhD, Director

Mission statement:
To provide investigators with the possibility of screening chemical libraries in a variety of readout systems for new bioactive compounds, prospective therapeutics and research tools.

Introduction:
The establishment of the Small Molecule Screening Core Facility created a unique opportunity for members of the RPCI research team to screen a collection of small “drug-like” molecules for new research tools and prospective diagnostic and therapeutic compounds. Now researchers at RPCI and other biomedical institutions in the Buffalo area can get assistance with the design and execution of chemical screenings in a variety of readout systems.

Located on the RPCI campus, the SMSC facility provides easy access to investigators during all stages of the screening project: design and adjustment of readout, high throughput screening, hit selection and conformation, preliminary hit characterization and structure-activity relationship (SAR) analysis. The collection of chemicals at SMSC totals more than 58,000 compounds. Sophisticated automated liquid handling equipment is used to ensure accurate delivery of this library in both the 96- and 384-well format, and our detection equipment allows for screening using either cell based or biochemical assays.

Contact:
Mikhail Chernov, Ph.D.
Office: 716-845-3404
Lab: 716-845-4697
Fax: 716-845-3944
E-mail: mikhail.chernov@roswellpark.org

Location:
BLSC, First floor, L1-111

Personnel:
Anatoly Prokvolit, MS, Translational Research Scientist
Lab: 716-845-4697
E-mail: anatoly.Prokvolit@RoswellPark.org

Operating Hours:
Monday-Friday, 9:00am-5:00pm