Lakshmi Pendyala, PhD
Director Preclinical/Clinical Drug Development Section
E-mail: lakshmi.pendyala@roswellpark.org

Josephia Muindi, PhD
Director, Steroid Hormone/Vitamin D Section
E-mail: josephia.muindi@roswellpark.org

Gerald Fetterly, PhD
Associate Director/Preclinical/Clinicla Pharmacology and PK/PD Modeling
Email: gerald.fetterly@roswellpark.org

Zengru Wu, PhD
Analytical Chemist/Mass Spectrometrist
E-mail: zengru.wu@RoswellPark.org

Joshua Prey, MS
Research Associate/Lab Manager
E-mail: joshua.prey@roswellpark.org

Kimberly Clark, MS
Research Associate
E-mail: kim.clark@roswellpark.org

Michelle Vinci, BS
Research Technologist
Email: michelle.vinci@roswellpark.org

Michael Murphy
Lab Technician
E-mail: michael.murphy@roswellpark.org

Mission

The mission of the Resource is to support clinical research and clinical/pre-clinical drug development at RPCI by providing state of the art analytical scientific data and PK/PD modeling and simulation services for PK/PD studies of cancer therapuetic and preventive agents with cost effectiveness. In addition, advise investigators on PK/PD study design, sample collection and handling, and guide dose selection for optimizing the therapeutic window of oncology drug products.

Description

The PK/PD Resource at RPCI is organized into two sections: 1:  The PK/PD section of preclinical/clinical drug development which covers the investigator-initiated pre-clinical, clinical studies including Phase I and Phase II clinical trials is directed by Lakshmi Pendyala, PhD, Department of Medicine. 2. The PK/PD section of steroid hormone/Vitamin-D program is directed by Josephia Muindi, MD, PhD, Department of Medicine. 

The PK/PD Resource provides complete services to investigators, ranging from study design consultation and methodology development, to storage, preparation and assay of samples, and data analysis. The Resource offers a wide variety of analytical assays along with the capabilities to develop and validate new methods. Using state-of-the-art techniques with LC/MS/MS, UPLC, HPLC,  and Atomic Absorption spectrophotometry, the PK/PD facility provides highly sensitive measurements for a wide array of chemotherapeutic agents and metabolites.  A recently acquired UV, fluorescence plate reader with 6 to 384-well read-capability for assays that require UV or fluorescence detection is also available for the PK/PD resource users.

PK/PD Resource is equipped with the following instrumentation:

• Thermo Scientific TSQ Quantum Ultra triple quadrupole ESI/APCI-LC/MS/MS
• Applied Biosystems API 3000 triple quadrupole LC/MS/MS
• Waters Ultra Performance Liquid Chromotagraphy System
• Waters High Performance Liquid Chromatography System
• Agilent  High Performance Liquid Chromatography System
• Perkin Elmer AAnalyst 600 Graphite Furnace Atomic Absorption
• Biotek Synergy Plate Reader providing flouresence and UV detection

 PK/PD Resource also is equiped with state of the art PK/PD modeling software including :

• WinNonlin Professional----for noncompartmental analysis and compartmental modeling for PK and/or PK/PD data
• ADAPT II---- for individual compartmental PK and PK/PD modeling
• NONMEM----nonlinear mixed effect modeling software for population analysis to ascertain sources of variability in both pharmacokinetics and pharmacodynamics of a drug
• WinPOPT----used to provide information for PK and/or PK/PD sampling strategies

Location

Basic Science Building, 3rd Floor
GCDC Building, 3rd Floor

Operating Schedule

Weekdays, 8:30 a.m. - 5:00 p.m.

Using the Facility

Investigators interested in the use of the facility should contact Drs. Pendyala, Muindi, or Fetterly,  or any of the staff listed above to discuss scheduling and procedures. You may also contact the team here: 

• Phone: 716-845-3303
• Fax: 716-845-1659

Services

Please see our services page for more details. Current assay list and price schedules are available here. PK/PD Resource also provides methods development and validation. Please contact our facility for any developmental needs.