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Publications
Recent Publications Resulting from Use of the Gene Expression Resource
1. Cao S, Durrani FA, Rustum YM. Synergistic antitumor activity of capecitabine in combination with irinotecan against human tumor xenografts. Clin Colorectal Cancer 2005; 4(5): 336-343
2. Chaar Z, O'Reilly P, Gelman I, Sabourin LA. V-SRC-dependent down-regulation of the Ste20-like kinase SLK by casein Kinase II. J Biol Chem 2006; 281(38): 28193-28199
3. Cowell JK, Hawthorn L. The application of microarray technology to the analysis of the cancer genome. Current Molec Med 7:1:103-120, 2007.
4. Diaz-Meyer N, Day CD, Khatod K, Maher ER, Cooper W, Reik W, Junien C, Graham G, Algar E, Der Kaloustian VM, Higgins MJ. Silencing of CDKN1C (p57KIP2) is associated with hypomethylation at KvDMR1 in Beckwith-Wiedemann syndrome. J Med Genet 2003; 40: 797-801
5. Dolnick R, Wu Q, Angelino NJ, Stephanie LV, Chow K-C, Sufrin JR, Dolnick BJ. Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells. Cancer Res 2005; 65(13): 5917-5924
6. Dong Y, Zhang H, Gao AC, Marshall JR, Ip C. Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer specific biomarkers. Mol Cancer Ther 2005; 4(7): 1047-1055
7. Dong Y, Zhang H, Hawthorn L, Ganther HE, Ip C. Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Res 2003; 63(1): 52-59
8. Ewart-Toland Am, Dai Q, Gao Y-T, Nagase H, Dunlop MG, Farrington SM, Barnetson RA, Anton-Culver A, Peel D, Ziogas A, Lin D, Miao X, Sun T, Ostrander EA, Stanford JL, Langlios M, Chan JM, Yuan J, Harris C, Bowman E, Clayman GL, Lippman SM, Lee JJ, Zheng W, Balmain A.. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis 2005; 26(8): 1368-1373
9. Ford RJ, Shen L, Lin-Lee YC, Pham LV, Multani A, Zhou H-J, Tamayo AT, Zhang CJ, Hawthorn L, Cowell J, Ambrus JL. Development of a murine model for mantle cell lymphoma. Blood. 2007 Feb 20; [Epub ahead of print]
10. Hansel DE, Rahman A, Hidalgo M, Thuluvath PJ, Lillemoe KD, Shulick R, Ku JL, Park JG, Miyazaki K, Ashfaq R, Wistuba II, Varma R, Hawthorn L, Geradts J, Argani P, Maitra A. Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol 2003; 163(1): 217-229
11. Hawthorn L, Stein L, Panzarella J, Loewen GM, Baumann H. Characterization of cell-type specific profiles in tissues and isolated cells from squamous cell carcinomas of the lung. Lung Cancer 2006; 53(2): 129-142
12. Hawthorn L, Stein L, Varma R, Wiseman S, Loree T, Tan D. TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma. Head Neck 2004; 12: 1063-1083
13. Huang H, Groth J, Sossey-Alaoui K, Hawthorn L, Beall S, Geradts J. Aberrant expression of novel and previously described cell membrane markers in human breast cancer cells lines and tumors. Clin Cancer Res 2005; 11 (12): 4357-4364
14. Ionov Y, Nowak N, Perucho M, Markowitz S, Cowell JK. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability. Oncogene 2004; 23(3): 639-645
15. Ivanov I, Hawthorn L, Cowell JK, Ionov Y. Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated MRNA decay in colon cancer cells. Oncogene In Press on 11/6/2006
16. Kasyapa CS, Kunapuli P, Hawthorn L, Cowell JK. Induction of the plasminogen activator inhibitor-2 in cells expressing the ZNF198/FGFR1 fusion kinase that is involved in a typical myeloproliferative disease. Blood 2006; 107(9): 3693-3699
17. Kimura MT, Mori T, Conroy J, Nowak NJ, Satomi S, Tamai K, Nagase H. Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) co-ordinately increase esophageal cancer. Cancer Res 2005; 65(9): 3548-3554
18. Kunapuli P, Chitta KS, Hawthorn L, Cowell JK. LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the Erk1/2 pathway. J Biol Chem 2004; 279(22): 23151-23157
19. Liu Y, Gao L, Gelman IH. SSeCKS/Gravin/AKAP 12 attenuates expression of proliferative and angiogenetic genes during suppression of v-Src-induced oncogenesis. BMC Cancer 2006; 6: 105
20. Liu W, Konduri SD, Bansal S, Nayak BK, Rajasekaran SA, Karuppayil SM, Rajasekaran AK, Das GM. Estrogen receptor-(alpha) binds p53 tumor suppressor protein directoy and represses its function. J Biol Chem 2006; 281(15): 9837-9984
21. Lo KC, Rossi MR, Burkhardt T, Pomeroy SL, Cowell JK. Overlay analysis of the oligonucleotide array gene expression profiles and copy number abnormalities as determined by array comparative genomic hybridization in medulloblastomas. Genes Chromosomes Cancer 2007; 46(1): 53-66
22. Lo KC, Rossi MR, LaDuca J, Hicks DG, Turpaz Y, Hawthorn L, Cowell JK. Candidate glioblastoma development gene identification using concordance between copy number abnormalities as define by array comparative genomic hybridization and gene expression level changes. Genes Chromosomes Cancer Submitted on 1/10/2007
23. Maitra A, Hansel DE, Argani P, Ashfaq R, Rahman A, Naji A, Deng S, Geradts J, Hawthorn L, House MG, Yeo CJ. Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. Clin Cancer Res 2003; 9(16 Pt 1): 5988-5995
24. Matsuyama T, Kimura MT, Koike K, Abe T, Nakano T, Asami T, Ebisuzaki T, Held WA, Yoshida S, Nagase H. Global methylation screening in the Arabidopsis thaliana and Mus musculus genome: Applications of virtual image restriction landmark genomic scanning (Vi-RLGS). Nucleic Acids Res 2003; 31(15): 4490-4496
25. Pan L, Gross KW. Transcriptional regulation of renin. An update. Hypertension 2005; 45: 3-8
26. Ramachandran L, Burhans DT, Laun P, Wang J, Liang P, Weinberger M, Wissing S, Jarolim S, Suter B, Madeo F, Breitenbach M, Burhans WC . Evidence for ORC-dependent repression of budding yeast genes induced by starvation and other stresses. FEMS Yeast Res 2006; 6: 763-776
27. Rossi MR, Hawthorn L, Platt J, Burkhardt T, Cowell JK, Ionov Y. Identification of inactivitating mutations in the JAK1, SYNJ2 and CLPTM1 genes in prostate cancer cells using inhibition of nonsense mediated decay and microarray analysis. Cancer Genet Cytogenet 2005; 161(2): 97-103
28. Rossi MR, Ionov Y, Bakin AV, Cowell JK. Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells. Cancer Genet Cytogenet 2005; 163(2): 123-129
29. Rossi MR, LaDuca J, Matsui S-I, Nowak NJ; Hawthorn L, Cowell JK. Novel amplicons on the short arm of chromosome 7 identified using high resolution array CGH define over expressed genes in addition to EGFR in glioblastoma multiiforme. Genes Chromosomes Cancer 2005; 44(4): 392-404
30. Shah YM, Al-Dhaheri M, Dong Y, Ip C, Jones FE, Rowan BG. Selenium disrupts estrogen receptor alpha signaling and potentiates tamoxifen antagonism in endometrial cancer cells and tamoxifen-resistant breast cancer cells. Mol Cancer Ther 2005; 4(8): 1239-1249
31. Tu LC, Matsui S-I, Beerman TA. The monofunctional DNA alkylator hedamycin induces persistent DNA breaks that activate H2AX in a PIKK independent manner and does not require DNA replication fork movement. Mol Cancer Ther 2005; 4(8): 1175-1185
32. Varma RR, Hector SM, Clark K, Greco WR, Hawthorn L, Pendyala L. Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10. Oncol Rep 2005; 14(4): 925-932
33. Varma R, Hector S, Greco W, Clark K, Hawthorn L, Porter C, Pendyala L. Platinum drug effects on the expression of gene in polyamine pathway-time course and dose response analysis of the Affymetrix gene expression profiling in A2780 ovarian carcinoma cells. Cancer Chemother Pharmacol 2007; 59(6): 711-723
34. Singh U, Sun T, Larsson T, Elliott RW, Kostka G, Fundele RH. Expression and functional analysis of Fibulin-1 (Fbln1) during normal and abnormal placental development of the mouse. Placenta 2006; 27(9-10): 1014-1021
35. Zhang H, Dong Y, Zhao H, Brooks JD, Hawthorn L, Nowak N, Marshall JR, Gao AC, Ip C. Microarray data mining for potential selenium targets in chemoprevention of prostate cancer. Cancer Genomics Proteomics 2005; 2(2): 97-113
36. Zu K, Hawthorn L, Ip C. Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by alpha-tocopheryl succinate in human prostate cancer cells. Mol Cancer Ther 2005; 4(1): 43-50
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