Gene Expression Resource

Roswell Park Cancer Institute

Elm and Carlton Streets

Basic Life Science Center (BLSC)

L1-120 

Buffalo, NY 14263

Norma Nowak, PhD (Interim Director)

Telephone: (716) 845-7649

Fax: (716) 845-4928

Email: norma.nowak@roswellpark.org 

Jenniffer Rothschild (Panzarella)

Research Associate

Telephone: 845-3958

Email: Jenniffer.Rothschild@RoswellPark.org

 

Jesse Luce

Research Technologist

Telephone: 845-1740

Email: Jesse.Luce@RoswellPark.org

 

 

 

Monday-Friday, 9:00am-5:00pm

 

 

 

The Gene Expression Resource has been operational since January 2001 and primarily provides Affymetrix GeneChip technology to researchers at Roswell Park Cancer Institute (RPCI) and the University at Buffalo and their collaborators. The Resource aims to provide RPCI researchers with access to microarray technology and bioinformatics at an affordable cost, and to provide training to the research community through educational seminars for analysis of microarray data and programs designed to analyze large data sets. For information on GeneChip technology, the various types of GeneChips and organisms represented please visit http://affymetrix.com/index.affx.

 

The Resource maintains and provides training for real-time quantitative PCR for extension of GeneChip data and validation studies. Also available are, a Transgenomic Wave System which is used for mutation or polymorphism studies on relatively large strands of DNA (100-160 bp), and a Pyrosequencing System that is a high throughput instrument capable of identification and analysis of small nucleotide polymorphisms (SNPs) in short strands of DNA. Having access to these systems provides investigators high throughput platforms for researching any type of sequence variation.

 

The study of gene expression and the investigation into the roles of sequence variation in the genome are thought to be natural adjuncts to microarray analysis. Training, support and consultation are provided for investigation into the roles of DNA sequence variation in the genome.

 

Software and training are provided for researchers to enable them to analyze large data sets and obtain meaningful results from these experiments. A large number of state-of-the-art programs are available to afford analyses of different data types and the expertise is available to implement and advise on their usage.