E-mail: MuhammedTaju.Kariapper@RoswellPark.org

Dr. Kariapper who comes from a multidisciplinary research background joined the Department of Radiation Medicine, Roswell Park Cancer Institute in October of 2004. He earned his PhD in Chemistry at the University of Toledo, Ohio. After graduation he underwent post doctoral training at the Medical School of University of Michigan studying TGF-alpha/Smad and sonic hedgehog signaling pathways using biochemical, cell & molecular biological methods, and transgenic mouse tumor model. Later he joined the Department of Radiation Oncology at the University of Michigan where he was studying molecular and magnetic resonance imaging of small animal models as well as anti-angiogenesis research.

His current nanotechnology based translational and preclinical research in Dr. Khan’s laboratory focuses on designing and biological characterization of nanodevices for cancer imaging and therapy

Selected publications

1. *Lesniak WG, *Kariapper MST, Nair BM, Tan W, Hutson A, Balogh LP, Khan MK. (2007) “Synthesis and Characterization of PAMAM Dendrimer-Based Multifunctional Nanodevices for Targeting alpha(v)beta(3) Integrins” Bioconjug Chem. 2007 Jun 13 (*equal contribution)
2. Mamou F, May K, Schipper MJ, Gill N, Kariapper MST, Nair BM, Brewer G, Normolle D, Khan MK (2006) “Tetrathiomolybdate Blocks bFGF- but not VEGF-induced Incipient Angiogenesis In Vitro” Anticancer Research. 26(3A):1753-8
3. Moffat BA, Chen M, Kariapper MST, Hamstra DA, Hall DE, Stojanovska J, Johnson TD, Blaivas M, Kumar M, Chenevert LT, Rehemtulla A, and Ross BD (2006) “Inhibition of VEGF-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D” Clinical Cancer Research (Imaging, Diagnosis, Prognosis ) 12(5) 1525 
4. Khan MK, Mamou F, Schipper MJ, May K, Kwitny A, Warnat A, Bolton B, Nair BM, Kariapper MST, Miller M, Brewer G, Normolle D, Merajver S and Teknos T (2006) “Combination of Tetrathiomolybdate and Radiation in a Mouse Model of HNSCC” Archives of Otolaryngology—Head & Neck Surgery 132(3), 333
5. Khan MK, Nigavekar SS, Minc LD, Kariapper MST, Nair BN, Lesniak WG and Balogh LP (2005) “In Vivo Biodistribution of Dendrimers and Dendrimer Nanocomposites – Implications for Cancer Imaging and Therapy” Technology in Cancer Research & Treatment 4, (6) 603-13
6. Hutchin ME, Kariapper MST, Grachtchouk M, Wang A, Wei L, Cummings D, Liu J, Michael LE, Glick A, Dlugosz AA (2005) “Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle” Genes & Development 15; 19(2):214-23.
7. Hutchin, ME; Kariapper, MST; Grachtehouk, M; et al. (2004) “Conditional expression of Gli2 in skin reveals a requirement for sustained hedgehog signaling in basal cell carcinoma growth” Journal of Investigative Dermatology 122 (3): A27-A27 157
8. Brault, P. A.; Kariapper, MST; Pham, CV; Flowers II, RA; Gunning, WT; Shah, P.; Funk, MO, Jr. (2002) “Protein Micelles from Lipoxygenase 3” Biomacromolecules 3: 649-654
9. Kariapper, MST; Dunham, W. R.; and Funk, MO (2001) “Iron Extraction from Soybean Lipoxygenase 3 and Reconstitution of Catalytic Activity from the Apoenzyme” Biochemical and Biophysical Research Communications. 273: 677-680.
10. Zimmerman, C., S.; Kariapper, MST; Mathews, L. S.; (1998) “Smad Proteins Physically Interact with Calmodulin” Journal of Biological Chemistry. 273: 677-680.