Affiliate Member
Department of Immunology
Roswell Park Cancer Institute
Instructor
Immunology Program
Roswell Park Graduate Division
University at Buffalo
Dr. William J. Magner joined the faculty of Roswell Park Cancer Institute in 1999 as a Research Scientist in the Department of Immunology, and was appointed Affiliate Member in 2000.
Dr. Magner earned his doctoral degree in Biochemistry, with a minor in Immunology, from Case Western Reserve University, Cleveland, OH, in 1994. Between 1994 and 1999, he completed postdoctoral fellowship training at the National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD. Dr. Magner also is Instructor, Immunology Program, Roswell Park Graduate Division, University at Buffalo.
Dr. Magner’s research interests, in collaboration with Dr. Tomasi, include the role of miRNA in regulating immune gene expression; the effect of histone acetylation on gene expression; effect of trichostatin A treatment on expression of genes of immunological interest in various tumors; use of targeted therapeutics which activate immune gene expression and enhance tumor immunogenicity; definition of the mechanisms of action of trichostatin A.
Dr. Magner has authored or co-authored a number of journal publications and abstracts.
Key Publications:
Khan AN, Magner WJ, Tomasi TB. An epigenetic vaccine model active in the prevention and treatment of melanoma. J Transl Med. 2007 Dec 10;5(1):64.
Asirvatham AJ, Gregorie CJ, Hu Z, Magner WJ, Tomasi TB. MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol. 2008 Apr;45(7):1995-2006.
Tomasi TB, Magner WJ, Khan AN. Epigenetic regulation of immune escape genes in cancer. Cancer Immunol Immunother. 2006 Oct;55(10):1159-84.
Chou SD, Khan AN, Magner WJ, Tomasi TB. Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. Int Immunol. 2005 Nov;17(11):1483-94.
Magner WJ, Tomasi TB. Apoptotic and necrotic cells induced by different agents vary in their expression of MHC and costimulatory genes. Mol Immunol. 2005 May;42(9):1033-42.
Khan AN, Magner WJ, Tomasi TB. An epigenetically altered tumor cell vaccine.
Cancer Immunol Immunother. 2004 Aug;53(8):748-54.
Magner WJ, Kazim AL, Stewart C, Romano MA, Catalano G, Grande C, Keiser N, Santaniello F, Tomasi TB. Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. J Immunol. 2000 Dec 15;165(12):7017-24.
Magner WJ, Chang AC, Owens J, Hong MJ, Brooks A, Coligan JE. Aberrant development of thymocytes in mice lacking laminin-2. Dev Immunol. 2000;7(2-4):179-93.
Magner WJ, Tomasi TB. Chromatin-immune connections: regulation of MHC and other genes. J Reprod Immunol. 2000 Aug;48(1):1-15.
Halvorson MJ, Magner W, Coligan JE. alpha4 and alpha5 integrins costimulate the CD3-dependent proliferation of fetal thymocytes. Cell Immunol. 1998 Oct 10;189(1):1-9.
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