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Lesniak, Wojciech G., PhD
E-mail: Wojciech.Lesniak@RoswellPark.orgDr. Wojciech G. Lesniak joined the Roswell Park Cancer Institute in 2005 as a Research Associate in the Department of Radiation Medicine (Nanotechnology Research). He earned his PhD in Bioinorganic and Biomedical Chemistry (2001) and his MS in Chemistry (1997) at the University of Wroclaw, Poland. He completed his post-doctoral training at the University of Michigan.
Dr. Lesniak's research involves the modification and analysis of PAMAM dendrimers and the analysis and fabrication of nanocomposites. He is particularly interested in the potential to use nanomaterials in cancer diagnosis and therapy, medical imaging, contrast agents, targeted drug delivery, and quantum dots.
Dr. Lesniak is a member of
- The American Chemical Society - Member since 2005
- Sigma Xi The Scientific Research Society - Member since 2004
- The American Association for Cancer Research - Member since 2006
- Nano Science and Technology Institute - Member since 2006
- American Academy of Nanomedicine - Member since 2006
- Association for Research in Otolaryngology Member 2001 - 2003
Dr. Lesniak has authored or coauthored more than 35 journal publications, book chapters and abstracts.
Selected Publications
1. Lesniak, W. G.; Kariapper, M. S. T.; Nair, B. M.; Balogh,L. P.; Khan, M. K. Synthesis and Characterization of PAMAM Dendrimer Multifunctional Composite Nanodevices for Targeting avb3 Integrins. 2007, Bioconjugate Chemistry in press available online.
2. Balogh, L.; Nigavekar, S. S.; Lesniak, W.; Zhang, Ch.; Sung, L. Y.; Nair, B. M.; Kariapper, M. S. T.; El-Jawahri, A.; Llanes, M.; Bolton, B.; Mamou, F.; Minc, L.; M. Khan, K. Significant Effects of Size and Charge on the in vivo Biodistribution of Composite Nanodevices in a Mouse Melanoma Tumor Model System. 2006 submitted.
3. Lesniak, W.; Shi, X.; Bielinska, A. U.; Janczak, K. W.; Sun, K.; Baker Jr. J. R.; and Balogh, L. P. Silver/Dendrimer Nanocomposites as Biomarkers: Fabrication, Characterization, In Vitro Toxicity and Intracellular Detection, Nano Letters 5(11): 2123-2130, 2005.
4. Khan, M. K.; Nigavekar, S. S.; Kariapper, M. S. T.; Nair, B. M.; Lesniak, W. G.; Balogh, L. P. Host-Guest Nanodevices: In Vivo Biodistribution of Dendrimers and Dendrimer Nanocomposites - Implications for Cancer Imaging and Therapy. TCRT 4(6): 603-613, 2005.
5. Lesniak, W.; Pecoraro, V. L. Schacht, J. Ternary Complexes of Gentamicin with Iron And Lipid Catalyze Formation of Reactive Oxygen Species. Chem. Res. Tox. 18: 357-364,2005.
6. Shi X, Banyai I.; Lesniak, W. G.; Islam, MT.; Orszagh, I.; Balogh, P.; Baker, JR Jr.; Balogh, L P. Capillary electrophoresis of polycationic poly(amidoamine) dendrimers. Electrophoresis., 26(15): 2949-59, 2005.
7. Shi, X.; Patri, A.; Banyai, I.; Lesniak, W.; Islam, M. T.; Baker, J. R. Balogh, L. Analysis of poly(amidoamine)-succinamic acid dendrimers by slab-gel electrophoresis and capillary zone electrophoresis. Electrophoresis 26(15): 2960-7, 2005.
8. Shi, X.; Banyai, I.; Lesniak, W.; Islam, M. T.; Davis, D. Z.; Baker, J. Balogh, L. Generational, skeletal and substitutional diversities in generation one poly(amidoamine) dendrimers Polymer, 46: 3022-30-34; 2005.
9. Lesniak, W.; Shi, X.; Islam, M. T.; Bielinska, A.; Janczak, K.; Sun, K.; Baker, J. R.; Balogh, L. P. Labeling Cells with Nanocomposites. MRS Proceedings, 845 AA5.37, 2004.
10. Lesniak, W.; Harris, W. R.; Yudenfreud-Kraviz. J.; Schacht, J., Pcoraro, V. L. Solution chemistry of copper(II)-gentamicin complexes: Relevance to metal-related aminoglycoside toxicity. Inorg. Chem. 42:1420-1429, 2003.
11. Lesniak, W.; Mc Laren, J.;Harris, W. R., Pecoraro V. L.; Schacht, J. An Isocratic Separation of Underivatized Gentamicin Components, 1H NMR Assignment
and Protonation Pattern. Carbohydr. Res. 338: 2853-2862, 2003.
12. Wang, A.; Sha, S.; Lesniak, W.; Schacht, J. Tanshinone preparations (Salviae Miltiorrhizae extract) attenuate aminoglycoside induced free radical formation
in vitro and ototoxicity in vivo. Antimicrob. Agents Ch. 47: 1836-1841, 2003.
13. Jezowska-Bojczuk, M.; Szczepanik , W.; Lesniak, W.; Ciesiolka, J.; Wrzesinski, J.; Bal; W. DNA and RNA damage by Cu(II)-amikacin complex. Eur. J. Biochem., 269: 5547-5556, 2002.
14. Jezowska-Bojczuk, M.; Lesniak, W.; Bal, W.; Kozlowski, H.; Gatner, K.; Jezierski, A.; Sobczak, J.; Mangani, S.; Meyer-Klaucke, W. Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes. Chem. Res. In Toxicol. 14: 1353-1362, 2001.
15. Jezowska-Bojczuk, M.; Szczepanik, W.; Bal, W.; Lesniak, W.; Ciesiolka, J.; Wrzesinski, J. DNA and RNA damage by Cu(II)-amikacin complex - a possible element of ototoxicity of aminoglycosides, J. Inorg. Biochem. 86: 280-280, 2001.
16. Jezowska-Bojczuk, M.; Lesniak, W.; Szczepanik, W.; Gatner, K.; Jezierski, A.; Smoluch, M.; Bal, W. Copper(II)-lincomycin: complexation pattern and oxidative activity. J. Inorg. Biochem. 84: 189-200, 2001.
17. Jezowska-Bojczuk, M.; Lesniak, W. Coordination mode and reactivity of copper(II) complexes with kasugamycin. J. Inorg. Biochem. 85: 99-105, 2001.
18. Krezel, A.; Lesniak, W.; Jezowska-Bojczuk, M.; Mlynarz, P.; Brasun, J.; Kozlowski, H.; Bal, W. Coordination of heavy metals by dithiothreitol, a commonly used thiol group protectant. J. Inorg. Biochem. 84: 77-88, 2001.
19. Kowalik-Jankowska, T.; Lesniak W.; Brasun, J.; Stasiak, M.; Leplawy, M. T. Copper(II) complexes of deltakephalin and its analogues containing alpha-hydroxymethylserine. Polyhedron 19: 241-245, 2000.
20. Boduszek, B.; Latajka, R.; Lesniak, W. Acid-catalyzed cleavage of 2-pyridyl and 4-pyridyl derivatives of aminomethylphosphonic acid. Kinetic and chemical arguments for a mechanism with A-S(E)2 character. Phosphorus Sulfur 165: 53-75, 2000.
