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Kasturirangan, Venugopalan, PhD
E-mail: Venugopalan.Kasturirangan@RoswellPark.orgDr. Venugopalan Kasturirangan earned his Ph.D., in Biochemistry and Molecular Biology from North Dakota State University, where he specialized in the study of acyl-CoA dehydrogenase and acyl-CoA oxidase catalyzed reactions. Dr. Kasturirangan received his post-doctoral training in the Microbiology Department of GlaxoSmithKline Pharmaceuticals where his research focused on biochemical aspects of anti-bacterial compounds and antibiotic resistance.
Owing to his interest in cancer research, he joined the laboratory of Dr. John McGuire as a post-doctoral associate in the Pharmacology and Therapeutics Department of Roswell Park Cancer Institute. During this period he investigated the signaling pathway involved in enhanced antifolate uptake in leukemic cells. Beginning March 2007, he joined the Department of Radiation Medicine under the supervision of Dr. Mohamed Khan to pursue the design and successful implementation of novel nanodevices for cancer therapy.
Owing to his interest in cancer research, he joined the laboratory of Dr. John McGuire as a post-doctoral associate in the Pharmacology and Therapeutics Department of Roswell Park Cancer Institute. During this period he investigated the signaling pathway involved in enhanced antifolate uptake in leukemic cells. Beginning March 2007, he joined the Department of Radiation Medicine under the supervision of Dr. Mohamed Khan to pursue the design and successful implementation of novel nanodevices for cancer therapy.
Selected publications
- Gopalan, K.V., and Srivastava, D.K. (2002) Beyond the proton abstracting role of Glu-376 in medium chain acyl-CoA dehydrogenase: Influence of Glu à Gln mutation on ligand binding and catalysis. Biochemistry 41, 4638-4648.
- Peterson, K.M., Gopalan, K.V., Nandy, A., and Srivastava, D.K. (2001) Unexpected changes in enthalpy and heat capacity for the binding of slightly altered ligands to wild-type and Glu-376 à Gln mutant forms of medium chain acyl-CoA dehydrogenase. Protein Science 10:1822-1834.
- Yishan, L., Wang, H.-J., Gopalan, K.V., Srivastava, D.K., Nicaud, J.-M., and Thierry, C. (2000) Purification and characterization of the recombinant form of acyl-CoA oxidase 3 (Aox3p) from the yeast Y.lipolytica. Arch. Biochem. Biophys. 384(1), 1-8.
- Peterson, K.M., Gopalan, K.V., and Srivastava, D.K. (2000) Influence of a-CH à NH substitution in C8-CoA on the kinetics of association and dissociation of ligands with medium chain acyl-CoA dehydrogenase. Biochemistry 39, 12659-12670.
- Gopalan, K.V., and Srivastava, D.K. (1997) Inhibition of acyl-CoA oxidase by phenol and its implication in measurement of the enzyme activity via the peroxidase-coupled assay system. Anal. Biochem. 250, 44-50.
- Hanley, P.J., Gopalan, K.V., Lareau, R.A., Srivastava, D.K., von Meltzer, M., and Daut, J. (2003) Beta-oxidation of 5-hydroxydecanoate, a putative blocker of mitochondrial ATP-sensitive potassium channels. J Physiol. 547(Pt.2), 387-93.
