Huss, Wendy, PhD

Dr. Wendy Huss joined the Roswell Park Cancer Institute (RPCI) in 2005 as Assistant Professor in the Department of Urologic Oncology. In 2008 she joined the Department of Pharmacology & Therapeutics.

Dr. Huss earned her doctoral degree in Molecular and Cellular Biology from Baylor College of Medicine, Houston, TX, in 2001 and completed a postdoctoral fellowship in the Department of Pathology and Laboratory Medicine from the University of North Carolina.

Dr. Huss has demonstrated ABCG2-medicated efflux of androgen in putative prostate stem cells and her research interests include the role of androgen regulation or prostate stem cells and targeting the malignant prostate stem cell as a source of recurrent prostate cancer.

Dr. Huss is a member of the American Association for Cancer Research, Society of Basic Urologic Research and Women in Cancer Research. She has authored or co-authored more than 30 articles and abstracts.

Key Publications

• Huss WJ, Gray DR, Tavakoli K, Marmillion ME, Durham LE, Johnson MA, Greenberg NM, Smith GJ.  Origin of Androgen Insensitive Poorly-Differentiated Tumors in the Transgenic Adenocarcinoma of Mouse Prostate Model. Neoplasia, 9: 938-950, 2007.
• Huss WJ, Gray DR, Greenberg NM, Mohler JL, Smith GJ. Breast Cancer Resistance Protein-Mediated Efflux of Androgen in Putative Benign and Malignant Prostate Stem Cells.  Cancer Research, 65: 6640-6650, 2005. 
• Huss WJ, Gregory CW, Smith GJ.  Neuroendocrine Cell Differentiation in the CWR22 Human Prostate Cancer Xenograft: Association with Tumor Cell Proliferation Prior to Recurrence. The Prostate, 60: 91-97, 2004. 
• Huss WJ, Gray DR, Werdin ES, Funkhouser WK, Smith GJ.  Evidence of Pluripotent Human Prostate Stem Cells in a Human Prostate Primary Xenograft Model. The Prostate, 60: 77-90, 2004. 
• Huss WJ, Lai L, Barrios RJ, Hirschi KK, Greenberg NM. Retinoic Acid Slows Tumor Progression and Promotes Apoptosis of Spontaneous Prostate Cancer. The Prostate, 61: 142-152, 2004. 
• Kaplan-Lefko PJ, Chen T-M, Ittmann MM, Barrios RJ, Ayala GE, Huss WJ, Maddison LA, Foster BA, Greenberg NM. Pathobiology of Autochthonous Prostate Cancer in a Pre-clinical Transgenic Mouse Model. The Prostate, 55: 219-237, 2003. 
• Huss WJ, Barrios RJ, Foster BA, Greenberg NM. Differential Expression of Specific FGF Ligand and Receptor Isoforms During Angiogenesis Associated with Prostate Cancer Progression. The Prostate, 54: 8-16, 2003. 
• Huss WJ, Maddison LA, Greenberg NM. Autochthonous Mouse Models for Prostate Cancer: Past, Present, and Future. Seminars in Cancer Biology, 11(3): 245-260, 2001. 
• Huss WJ, Hanrahan CF, Barrios RJ, Simons JW, Greenberg NM. Angiogenesis and Prostate Cancer: Identification of A Molecular Progression Switch. Cancer Research, 61: 2736-2743, 2001