• Garkavtsev, I.V., Kley, N., Grigorian, I.A. and Gudkov, A.V. (2001) The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control. Oncogene 20:8276-8280.
• Kondratov, R.V., Komarov, P.G., Becker, Y., Ewenson, A. and Gudkov, A.V. (2001) Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein. Proc Natl Acad Sci USA 98:14078-14083.
• Neznanov, N., Kondratova, A., Chumakov, K.M., Angres, B., Zhumabayeva, B., Agol, V.I. and Gudkov, A.V. (2001) Poliovirus protein inhibits tumor necrosis factor (TNF)-induced apoptosis by eliminating the TNF receptor from the cell surface. J Virol 75:10409-10420.
• Komarova, E.A. and Gudkov, A.V. (2001) Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors. Biochem Pharmacol 62:657-667.
• Botchkarev, V.A., Komarova, E.A., Siebenhaar, F., Botchkareva, N.V., Sharov, A.A., Komarov, P.G., Maurer, M., Gudkov, A.V. and Gilchrest, B.A. (2001) p53 Involvement in the control of murine hair follicle regression. Am J Pathol 158:1913-1919.
• Kwek, S.S., Derry, J., Tyner, A.L., Shen, Z. and Gudkov, A.V. (2001) Functional analysis and intracellular localization of p53 modified by SUMO-1. Oncogene 20:2587-2599.
• Skowyra, D., Zeremski, M., Neznanov, N., Li, M., Choi, Y., Uesugi, M., Hauser, C.A., Gu, W., Gudkov, A.V. and Qin, J. (2001) Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. J Biol Chem 276:8734-8739.
• Bacus, S.S., Gudkov, A.V., Lowe, M., Lyass, L., Yung, Y., Komarov, A.P., Keyomarsi, K., Yarden, Y. and Seger, R. (2001) Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 20:147-155.
• Komarova, E.A., Chumakov, P.M. and Gudkov, A.V. (2001) Tp53 in cancer origin and treatment. In Cancer Genetics, Second Edition, J. Cowell, ed. (BIOS Scientific Publishers Ltd. Series).
• Zou, X., Ray, D., Aziyu, A., Christov, K., Boiko, A.D., Gudkov, A.V. and Kiyokawa, H. (2002) Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev 16:2923-2934.
• Gudkov, A.V. (2002) Converting p53 from a killer into a healer (New and Views). Nat Med 8:1196-1198.
• Erez, N., Milyavsky, M., Goldfinger, N., Peles, E., Gudkov, A.V. and Rotter, V. (2002) Falkor, a novel cell growth regulator isolated by a functional genetic screen. Oncogene 21:6713-6721.
• Neznanov, N., Chumakov, K.P., Ullrich, A., Agol, V.I. and Gudkov, A.V. (2002) Unstable receptors disappear from cell surface during poliovirus infection. Med Sci Monit 8:BR 391-396.
• Rokhlin, O.W., Glover, R.A., Taghiyev, A.F., Guseva, N.V., Seftor, R.E., Shyshynova, I., Gudkov, A.V. and Cohen, M.B. (2002) Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription. J Biol Chem 277:33213-33219.
• Budanov, A.V., Shoshani, T., Faerman, A., Zelin, E., Kamer, I., Kalinski, H., Gorodin, S., Fishman, A., Chajut, A., Einat, P., Skaliter, R., Gudkov, A.V., Chumakov, P.M. and Feinstein, E. (2002) Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 21:6017-6031.
• Bacus, S.S., Altomare, D.A., Lyass, L., Chin, D.M., Farrell, M.P., Gurova, K., Gudkov, A., and Testa, J.R. (2002) AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene 21:3532-3540.
• Gurova, K.V., Roklin, O.W., Krivokrysenko, V.I., Chumakov, P.M., Cohen, M.B., Feinstein, E. and Gudkov, A.V. (2002) Expression of prostate specific antigen (PSA) is negatively regulated by p53. Oncogene 21:153-157.
• Gurova, K.V., Kwek, S.S., Koman, I.E., Komarov, A.P., Kandel, E., Nikiforov, M.A. and Gudkov, A.V. (2002) Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor. Cancer Biol Ther 1:39-44.
• Kondratov, R.V., Chernov, M.V., Kondratova, A.A., Gorbacheva, V.Y., Gudkov, A.V. and Antoch, M.P. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev 17:1921-1932.
• Kichina, J.V., Rauth, S., Das Gupta, T.K. and Gudkov, A.V. (2003) Melanoma cells can tolerate high levels of transcriptionally active endogenous p53 but are sensitive to retrovirus-transduced p53. Oncogene 22:4911-4917.
• Gudkov, A. (2003) Microarray analysis of p53-mediated transcription: multi-thousand piece puzzle or invitation to collective thinking. Cancer Biol Ther 2:444-445.
• Gurova, K.V., Rokhlin, O.W., Budanov, A.V., Burdelya, L.G., Chumakov, P.M., Cohen, M.B. and Gudkov, A.V. (2003) Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells. Cancer Res 63:2905-2912.
• Komarova, E.A., Neznanov, N., Komarov, P.G., Chernov, M.V., Wang, K. and Gudkov, A.V. (2003) p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem 278:15465-15468.
• Neznanov, N., Neznanova, L., Kondratov, R.V., Burdelya, L., Kandel, E.S., O'Rourke, D.M., Ullrich, A. and Gudkov, A.V. (2003) Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B. J Biol Chem 278:3809-3815.
• Gudkov, A.V. and Komarova, E.A. (2003) The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 3:117-129.
• Gros, L., Delaporte, C., Frey, S., Decesse, J., de Saint-Vincent, B.R., Cavarec, L., Dubart, A., Gudkov, A.V. and Jacquemin-Sablon, A. (2003) Identification of new drug sensitivity genes using genetic suppressor elements: protein arginine N-methyltransferase mediates cell sensitivity to DNA-damaging agents. Cancer Res 63:164-171.
• Gurova, K.V. and Gudkov, A.V. (2003) Paradoxical role of apoptosis in tumor progression. J Cell Biochem 88:128-137.
• Komarova, E.A. and Gudkov, A. V. (2003) Isolation of p53 inhibitors by screening chemical libraries in cell-based readout systems. In Methods in Molecular Biology, Vol. 223: Tumor Suppressor Genes, Vol. 2: Regulation, Function, and Medicinal Applications, W. el-Deiry, ed. (Totowa, N.J.: Humana Press), pp. Chapter 39, p. 635-648.
• Roninson, I.B. and Gudkov, A.V. (2003) Genetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor Genes. In Methods in Molecular Biology, Vol. 223: Analysis of Tumor Suppressor Genes, Vol. 1: Pathways and Isolation Strategies, W. El-Deiry, ed, (Totowa, N.J.: Humana Press), Chapter 26, p. 413-436.
• Vaziri, S.A., Hill, J., Chikamori, K., Grabowski, D.R., Takigawa, N., Chawla-Sarkar, M., Rybicki, L.R., Gudkov, A.V. , Mekhail, T., Bukowski, R.M., Ganapathi, M.K. and Ganapathi, R. (2005) Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin. Mol Cancer Ther. 4:1880-1890.
• Tarunina, M., Alger, L., Chu, G., Munger, K., Gudkov, A., and Jat, P.S. (2004) Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Mol Cell Biol 24:10792-10801.
• Gudkov, A. V. (2004) Cancer drug discovery, the wisdom of imprecision. Nat Med 10:1298-1299.
• Singhi, A.D., Kondratov, R.V., Neznanov, N., Chernov, M.V., and Gudkov, A.V. (2004) Selection-subtraction approach (SSA): a universal genetic screening technique that enables negative selection. Proc Natl Acad Sci USA 101:9327-9332.
• Lu, T., Burdelya, L.G., Swiatkowski, S.M., Boiko, A.D., Howe, P.H., Stark, G.R., and Gudkov, A.V. (2004) Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells. Proc Natl Acad Sci USA 101:7112-7117.
• Komarova, E.A., Wang, K., Kondratov, R.V., Christov, K., Golovkina, T.V., Goldblum, J. and Gudkov, A.V. (2004) Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoetic injury but protects from gastro-intestinal syndrome in mice. Oncogene 22:3265-3271.
• Gurova, K.V., Hill, J.E., Razorenova, O.V., Chumakov, P.M. and Gudkov, A.V. (2004) p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res 64:1951-1958.
• Neznanov, N., Neznanova, L., Kondratov, R.V., O'Rourke, D.M., Ullrich, A. and Gudkov, A.V. (2004) The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha. DNA Cell Biol 23:175-182.
• Neznanov, N., Neznanova, L., Angres, B. and Gudkov, A.V. (2005) Serologically Defined Colon Cancer Antigen 3 Is Necessary for the Presentation of TNF Receptor 1 on Cell Surface. DNA Cell Biol. 24:777-785.
• Gurova K.V., Hill, J.E., Prokvolit, A., Burdelya, L.G., Samoylova, E., Khodyakova, A.V., Ganapathi, R., Ganapathi, M., Tararova, N.D., Lvovsky, D., Webb, T.R. and Gudkov, A.V. (2005) Small molecules, reactivating p53 in renal cell carcinoma, reveal a new NF- k B-dependent mechanism of p53 suppression in tumors. PNAS 102:17448-17453.
• Kondratova, A.A., Neznanov, N, Kondratov, R.V. and Gudkov, A.V. (2005) Poliovirus Protein 3A Binds and Inactivates LIS1, Causing Block of Membrane Protein Trafficking and Deregulation of Cell Division. Cell Cycle 4:1403-1410.
• Marques, J.T., Rebouillat, D., Ramana, C.V., Murakami, J., Hill, J.E., Gudkov, A., Silverman, R.H., Stark, G.R. and Williams, B.R. (2005) Down-regulation of p53 by double-stranded RNA modulates the antiviral response. J Virol. 79:11105-11114.
• Gudkov, A.V. and Komarova E.A. (2005) Prospective therapeutic applications of p53 inhibitors. Biochem. Biophys. Res. Commun. 331:726-736.
• Neznanov, N., Chumakov, K.M., Neznanova, L., Almasan, A., Banerjee, A.K. and Gudkov, A.V. (2005) Proteolytic cleavage of the p65-RelA subunit of NF- k B during poliovirus infection. J Biol Chem 270:24153-24158.
• Komarova, E.A., Krivokrysenko, V.I., Wang, K., Neznanov, N., Chernov, M.V., Komarov, P.G., Brennan, M-L., Golovkina, T.V., Rokhlin, O.W., Kuprash, D.V., Nedospasov, S.A., Hazen, S., Feinstein, E. and Gudkov, A.V. (2005) p53 is a suppressor of inflammatory response in mice. FASEB J 19:1030-1032.
• Gudkov, A.V. (2005) Therapeutic strategies based on pharmacological modulation of p53 pathway. In “The p53 Tumor Suppressor Pathway and Cancer”, G. Zambetti, ed. Springer Series: Protein Reviews, Vol. 2.
• Gorbacheva, V.Y., Kondratov, R.V., Zhang, R., Cherukuri, S., Gudkov, A.V., Takahashi, J.S. and Antoch, M.P. (2005) Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. PNAS 102:3407-3412.
• Burdelya, L.G., Komarova, E.A., Hill, J.E., Browder, T., Tararova , N.D. , Marvrakis, L., DiCorleto, P.E., Folkman, J. and Gudkov, A.V. (2006) Inhibition of p53 Response in Tumor Stroma Improves Efficacy of Anticancer Treatment by Increasing Antiangiogenic Effects of Chemotherapy and Radiotherapy in Mice. Cancer Res. 66:9356-9361.
• Chikamori, K., Hill, J.E., Grabowski, D.R., Zarkhin, E., Grozav, A.G., Vaziri, S.A., Wang, J., Gudkov, A.V., Rybicki, L.R., Bukowski, R.M., Yen, A., Tanimoto, M., Ganapathi, M.K. and Ganapathi, R. (2006) Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest. Leukemia 10:1809–1818.
• Strom, E., Sathe, S., Komarov, P.G., Chernova, O.B., Pavlovska, I., Shyshynova, I., Bosykh, D.A., Burdelya, L.G., Macklis, R.M., Skaliter, R., Komarova, E.A. and Gudkov, A.V. (2006) Inhibition of p53 binding to mitochondria by small molecule is sufficient for radioprotection in vivo. Nature Chem. Biol. 2:474-479.
• Patton, J.T., Mayo, L.D., Singhi, A.D., Gudkov , A.V., Stark, G.R. and Jackson, M.W. (2006) Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. Cancer Res. 66:3169-3176.
• Kichina, J., Zeremski, M., Gurova, K.V., Kiyoka wa, H. and Gudkov, A.V. (2006) Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas. Oncogene 25:857-866.
• Boiko, A.D., Porteous, S., Razorenova, O.V., Krivokrysenko, V.I., Williams, B.R. and Gudkov, A.V. (2006) A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role