Department of Immunology
Roswell Park Cancer Institute
Elm and Carlton Streets
Buffalo, New York USA 14263
Tel: 716-845-3421
Fax: 716-845-8906
E-mail: sharon.evans@roswellpark.org

Lab Website: www.roswellpark.org/evans_lab

Current Program 

• Determining which downstream signaling pathways from IL-6 trans-signaling that are induced by fever-range thermal stress induce increased adhesion and ICAM-1 expression.
• Identifying which cells are the source of IL-6 and the soluble IL-6 receptor that enable IL-6 trans-signaling in the HEVs of lymphoid organs.
• Extending these studies into the tumor microenvironment to examine if the unique conditions there can be exploited by the inflammatory stimulus of thermal stress to increase T cell trafficking into tumor sites, by increasing specific adhesion characteristic of tumor vessels.
• Examining if thermal therapy can be used as an adjuvant to improve the responsiveness of patients to adoptive therapy treatments to increase infiltration of the tumor and patient outcome

Please select the link to the left to view a selected list of Dr. Evans' publications, or you can visit this link for a complete list through PubMed.

Profile

Dr. Sharon S. Evans joined the staff of Roswell Park Cancer Institute in 1971 as a research assistant in the Department of Medicine. She joined the Department of Immunology in 1987. She received her PhD in Phyisiology/Immunology (1984) from the Roswell Park Graduate Division of the State University of New York at Buffalo.

Dr. Evans is a member of the American Association for the Advancement of Science, International Society for Interferon and Cytokine Research, Sigma Xi Society, Beta Beta Beta Biological Honor Society, American Association of Immunologists, and North American Hyperthermia Society/Society for Thermal Medicine.