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Preclinical Imaging
| Contact info: | Lab: (716) 845-8896 |
Equipment
4.7 T 33 cm wide bore small animal MR instrument (CSI Omega, GE Medical Systems), upgraded to AVANCE 4.0 OS platform in 2007 (Bruker Biospin MRI, Inc., Billerica, MA) - Real-time fluorescence in vivo imaging system (Lightools, Research, Encinitas, CA)
- Multispectral fluorescence in vivo maging System (Maestro®, CRI, Boston, MA)
Description
The Preclinical Imaging staff specializes in imaging small animal models of disease. We provide training, guidance, technical services, quantitative image analysis of digitally acquired data sets, multidimensional visualization of results and small animal imaging expertise. Services currently include state-of-the-art MR imaging, MR spectroscopy, whole body fluorescence imaging (FI), multispectral optical imaging, customized data analysis and visualization of structural/functional relationships in vivo.
The staff also facilitates multimodality imaging research through collaborative interactions with regionally available instrumentation (e.g., microPET imaging, SUNY Buffalo, Dept. of Nuclear Medicine).
We offer turn-key and customized noninvasive imaging services developed for in vivo tumor characterization incorporating standard and non-standard MR imaging and spectroscopy techniques. For example, blood oxygenation level dependent (BOLD) functional MR (fMR) imaging techniques sensitive to changes in tumor oxygenation and microvascular status have been developed in-house and added to the growing arsenal of available tools to probe tumor physiology. Recently acquired whole body fluorescence in vivo imaging services offer investigators enhanced imaging sensitivity and specificity, real time visual analysis and low imaging cost per animal per time point – essential requisites for screening or phenotyping large cohorts of transgenic mice.
Noteworthy Accomplishments
Patents Filed Through the PIR
- Hybrid Inorganic Nanoparticles: Methods of Using and Methods of Making. Prasad PN, Mazurchuk R, Bharali DJ, Sukumaran DK, Bergey EJ, Spernayk J, Seshadri M. U.S. Patent Application No. #11/392,057. Filing Date: March 29th 2005.
- Optimizing Cancer Therapeutic Strategies Through Tumor Vessel Maturation Caused By Selenium. Bhattacharya A, Tóth, K, Mazurchuk R, Spernyak JA, Rustum YM. U.S. Patent Application No. #60/785,935. Filing Date: March 24th 2006.
Multi-DTPA Conjugated Tetrapyrollic Compounds for Phototherapeutic Contrast Agents. Pandey RK, Goswami L, Spernyak JA, Kanter P, Mazurchuk R. U.S. Patent Application No. #11/479,524 Filing Date: June 30th 2006.
Cover Art
- March 2005 Clinical Cancer Research
- March 2007 Journal of Biological Chemistry
Location
- 4.7 T MR Imaging System: Cancer Cell Center - Ground Floor, Room CCC164
- Fluorescence Imaging Systems: Cancer Cell Center - Ground Floor, Room CCC160
Using the Facility
Investigators should contact either Dr. Spernyak or Dr. Seshadri regarding the design, implementation and use of MRI of fluorescent imaging as a research tool for clinical and basic science studies.
Services
Both structural and functional data acquisitions
- Diagnostic MR Imaging Services: 1D, 2D and 3D acquisitions including spin echo (SE), gradient echo (GRE) and echo planar based methods
- Functional MR Imaging Services: fMR of tumors for assessment of microvasculature, blood level oxygenation dependent (BOLD) imaging, perfusion weighted imaging, diffusion weighted imaging, and heteronuclear MRS
- In Vivo Fluorescence Imaging: Multispectral and in vivo fluorescence imaging of GFP, RFP or other fluorescent probes and transgenic animals metabolically altered to express flourescence
- 2D and 3D Data Analysis: Post-Image Acquisition Processing and 3-D visualization of digital data sets (any modality): analysis packages include ANALYZE, Paravision, Amira, several proprietary software packages, Interactive Data Languages (IDL), etc.
Scheduling and Additional Information
Investigators should contact either Dr. Seshadri or Dr. Spernyak for details.
Billing Procedure
Investigators will be billed at an hourly rate according to use and supplies.
