Albanese C, D'Amico M, Reutens AT, Fu MF, Watanabe G, Lee RJ, Kitsis RN, Henglein B, Avantaggiati M. Somasundaram K, Thimmapaya B, Pestell RG. Activation of the cyclin D1 gene by the EPA-associated protein p300 through AP-1 inhibits cellular apoptosis. J.Biol.Chem., 274(48):34186-34195, 1999

Alhonen L, Pietila M, Halmekyto M, Kramer LD, Janne J, Porter CW. Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analogue, N1,N11-diethylnorspermine. Mol. Pharm. 54:693-698, 1999

Arbeit JM, Riley RR, Huey B, Porter CW, Kelloff G, Lubet R, Ward JM, Pinkel D. Difluoromethylornithine chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice. Cancer Res. 59:3610-3620, 1999

Bacchi CJ, Goldberg B, Rattendi D, Gorrell TE, Spiess AJ, Sufrin JR. Metabolic effects of a methylthioadenosine phosphorylase analog on African trypanosomes. Biochem. Pharmacol. 57:89-96, 1999

Barnes MJ, Estlin EJ, Taylor GA, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson ADJ, Newell DR. The effect of polyglutamation on sensitivity to classical antifolates in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in a CCRF-CEM cell line. Clin. Cancer Res. 5:2548-58, 1999

Berleth ES, Nadadur S, Henn AD, Eppolito C, Shiojiri S, Gurtoo HL, Ehrke MJ, Mihich E. Identification, characterization and cloning of TIP-B1, a novel protein inhibitor of Tumor Necrosis Factor induced lysis. Cancer Res. 59:5497-5506, 1999

Berleth ES, Ujhazy P, Meer JM, Dolnick BJ, Ehrke MJ. Measurement of low-abundance cytokine mRNA in cells of murine lymphoid organs: a new quantitative reverse transcription/polymerase chain reaction Method. Cancer Immunology and Immunotherapy, 48:471-481, 1999

Black AR, Azizkhan-Clifford J. Regulation of E2F: A family of transcription factors involved in proliferation control. Gene 237:281-302, 1999

Black AR, Jensen DE, Lin SY, Azizkhan JC. Growth/cell cycle regulation of Sp1 phosphorylation. J. Biol. Chem. 274:1207-1215, 1999

Blessing RH, Smith GD. Difference structure factor normalization for heavy-atom or anomalous scattering substructure determinations. J. Appl. Cryst. 32:664-670, 1999

Cao S, McGuire JJ, Rustum YM. Antitumor activity of ZD1694 (Tomudex) against human head and neck cancer in nude mouse models: Role of dosing schedule and plasma thymidine. Clin. Cancer Res. 5: 1925-1934, 1999

Cao S, Lu K, Toth K, Slocum HK, Shirasaka T, Rustum YM. Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-Fluorouracil prodrug in a colorectal tumor model. Clin. Can. Res. 5:267-274, 1999

Cmarik JL, Min HZ, Hegamyer G, Zhan SN, Kulesz-Martin M, Yoshinaga H, Matsuhashi S, Colburn NH. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc. Natl. Acad. Sci. USA 96(24):14037-14042, 1999

Dai HQ, Kramer DL, Yang CY, Murti KG, Porter CW. Cleveland JL. The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects. Cancer Res. 59(19):4944-4954, 1999

Darcy KM, Wohlhueter AL, Zangani D, Vaughan MV, Russell JA, Shoemaker E, Horn E, Lee P, Huang R, Varela L, Ip M. Selective changes in EGF receptor expression and function during the proliferation, differentiation, and apoptosis of mammary epithelial cells. Eur. J. Cell Biol. 78:511-523, 1999

Dimitroff CJ, Klohs W, Sharma A, Pera P, Driscoll D, Veith J, Steinkampf R, Schroeder M, Klutchko S, Sumlin A, Henderson B, Dougherty TJ, Bernacki RJ. Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: Implications for combination treatment with photodynamic therapy. Investigational New Drugs 17(2):121-135, 1999

Dimitroff CJ, Pera P, Dall'Olio F, Matta KL, Chandrasekaran EV, Lau JT, Bernacki RJ. Cell surface N-acetylneuraminic Acid *2,3 galactoside-dependent intercellular adhesion of human colon cancer cells. Biochem. Biophys. Res. Comm. 256:631-636, 1999

Dong Y, Asch H, Medina D, Ip C, Ip M, Guzman R, Asch B. Deregulation of gelsolin and cyclin D1 is common to the majority of breast cancers in humans and rodents. Int. J. Cancer 81:930-938, 1999

Evans SS, Bowman L, Schleider DM, Kansas G, Black JD. Association of L-selectin with the lymphocyte cytoskeletal matrix. J. Immunol. 162(6):3615-3124, 1999

Evans SS, Schleider DM, Bowman LA, Francis ML, Kansas GS, Black JD. Association of L-selectin with the lymphocyte cytoskeletal matrix. J. Immunol. 162(6):3615-3624, 1999

Faessel HM, Levasseur LM, Slocum HK, Greco WR. Parabolic growth patterns in 96-well plate cell growth experiments. In Vitro Cell Dev Biol. 35:270-278, 1999

Faessel HM, Slocum HK, Rustum YM, Greco WR. Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydor-3H-pyrimidino [5,4,6][1,4]thiazin-6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034). Biochem. Pharm. 57:567-577, 1999

Frydman B, Westler WM, Valsinas A, Kramer DL, Porter CW. Regioselective binding of spermine N1,N12Bisethylspermine to tRNAPheas revealed by 750 MHz 1H-NMR and its possible correlation with cell cylcing and cytotoxicity. Brazil. J. Biochem. 10:334-345, 1999

Giordano A, Avantaggiati ML. p300 and CBP: Partners for life and death. J. Cellular Physiology 181:218-230, 1999

Guo DY, Blessing RH, Langs DA, Smith GD. On 'Globicity' of low resolution protein structures. Acta Cryst. D55:230-237, 1999

Guo B, Yin MB, Cao S, Azrak RG, Rustum YM. Dimerization of mitochondrial Bax is associated with increased drug response in Bax-transfected A253 cells. Oncology Research 11:91-99, 1999

Ip MM, Masso-Welch PA, Shoemaker SF, Shea-Eaton WK, Ip C. Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture. Exp. Cell Res. 250:22-34, 1999

Kramer DL, Vujcic S, Diegelman P, Alderfer J, Miller JT, Black JD, Bergeron RJ, Porter CW. Differential induction of the p53/p21WAF1/CIP1-Rb pathway by polyamine analogs determines G1 arrest and programmed cell death responses in human melanoma cells. Cancer Res. 59:1278-1286, 1999

Langs DA, Blessing RH, Smith GD. Crunch: a phase refinement program for high resolution macromolecular structures. J. Appl Cryst. 32:664-670, 1999

Marquez VE, Goddard A, Alvarez E, Ford H, Christman JK, Sheiknejad G, Brank A, Marasco CJ, Sufrin JR, Ogara M, Cheng X. Oligonucleotides containing 5,6-dihydro-5-azacytosine at CpG sites can produce potent inhibition of DNA cytosine-C5-methyltransferase without covalently binding to the enzyme. Antisense & Nucleic Acid Drug Devel. 9:415-421, 1999

Masso-Welch PA, Black JD, Erikson J, Repasky EA. Polarized expression of immunoglobulin, spectrin, and protein Kinase C Beta II occurs in B cells from normal BALB/c, autoimmune 1pr and anti-ssDNA transgenic, tolerant mice. J. Leukocyte Biology 66(4):617-624, 1999

Masso-Welch PA, Verstovsek G, Ip MM. Alterations in the expression and localization of protein kinase C isoforms during mammary gland differentiation. Europ. J. Cell Biology 78:497-510, 1999

Matsui SI, Endo W, Wrzosek C, Haridas K, Seetharamulu P, Hausheer FH, Rustum YM. Characterisation of a synergistic interaction between a thymidylate synthese inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor Karenitecin, BNP1100: mechanisms and clinical implications. Europ. J. Cancer 35(6):984-993, 1999

McGuire JJ. Antifolate polyglutamylation in preclinical and clinical antifolate resistance. In: Anticancer drug development guide: antifolate drugs in cancer therapy, A.L. Jackman, Ed., Humana Press, Totowa, NJ, 1999, pp. 339-363

McGuire JJ, Canestrari JM, Nagel GS. Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on the growth of human squamous cell carcinoma of the head and neck and human leukemia cell lines. Int. J. Oncol. 15: 1245-50, 1999

McHugh MM, Beerman TA. C-1027 induced alterations in Epstein-Barr viral and mitochondrial DNA replication in latently infected cultured human Raji cells: Relationship to DNA damage. Biochemistry 38:6962-6970, 1999

McHugh MM, Beerman TA. Purification of large quantities of high molecular weight Epstein-Barr viral and cellular genomic DNA from cultured human Raji cells. Biotechniques 26:188-194, 1999

McHugh MM, Kuo SR, Walsh-O'Beirne MH, Liu JS, Melendy T, Beerman TA. Bizelesin, a bifunctional cyclopropylpyrroloindile alkylating agent, inhibits SV40 replication in trans. Biochemistry 38:11508-11515, 1999

Meropol NJ, Rustum YM, Creaven PJ, Blumenson LE, Frank C. Phase I and pharmacokinetic study of weekly 5-fluorouracil administered with granulocyte-macrophage colony-stimulating factor and high dose leucovorin: A potential role for growth factor as mucosal protectant. Cancer Investigations 17(1):1-9, 1999

Mihich E, Croce CM. Meeting report: Ninth Annual Pezcoller Symposium: The biology of tumors. Cancer Res. 59:491-497, 1999

Mihich E, Strong L, Klausner R. Meeting report: Tenth Annual Pezcoller Symposium: The genetics of cancer susceptibility. Cancer Res. 59:3271-3279, 1999

Minderman H, Cao S, Rustum YM. Rational design of Irinotecan administration based on preclinical models. Oncology 12(8):22-30, 1999

Nadadur SS, Ehrke MJ, Gurtoo HL. A novel TNF-inducible message with putative growth suppressor function. Biochim.Biophys. Acta Gene Struct. Expression 1489(2-3):433-439, 1999

Nair MG, Fayard ML, Lariccia JL, Amato AE, McGuire JJ, Galivan JH, Kisliuk RL. Metabolism blocked classical folate analogue inhibitors of dihydrofolate reductase-1: Synthesis and biological evaluation of mobiletrex. Med. Chem. Res. 9:176-185, 1999

Ojima I, Bounaud PY, Bernacki R.J. Designing taxanes to treat multidrug-resistant tumors. Modern Drug Discovery 2: 45-52, 1999

Ojima I, Wang T, Miller ML, Lin SN, Borella CP, Geng XD, Pera P, Bernacki RJ. Synthesis and structure-activity relationships of new second-generation taxoids. Bioorg. Med. Chem.Lett. 9(24):3423-3428, 1999

Richards JP, Stickelmeyer MP, Frank BH, Pye S, Barbeau M, Radziuk J, Smith GD, DeFelippis MR. Preparation of a Microcrystalline Suspension Formulation of LysB28ProB29-Human Insulin with Ultralente Properties. Journal of Pharmaceutical Sciences, 88:861-867,1999

Rustum YM, Cao S. New Drug in Therapy of Colorectal Cancer: Preclinical studies. Seminars in Oncology, 26(6):612-620, 1999

Sharma M, Slocum HK. Prevention of quinone-mediated DNA arylation by antioxidants. Biochem. Biophys. Res. Commun., 262(3):769-774, 1999

Sheikhnejad G, Brank A, Christman JK, Goddard A, Alvarez E, Ford H, Marquez VE, Marasco CJ, Sufrin JR, O'Gara M, Cheng XD. Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. J. Mol. Biol. 285(5):2021-2034, 1999

Suppola S, Pietila M, Parkkinen JJ, Korhonen VP, Alhonen L, Halmekyto M, Porter CW, Janne J. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: Evidence for a striking post-transcritional regulation of the transgene expression by a polyamine analogue. Biochem. J. 338:311-316, 1999

Vanhoefer U, Harstrick A, Kohne CH, Achterrath W, Rustum YM, Seeber S, Wilke H. Phase I study of a weekly schedule of irinotecan, high-dose leucovorin, and infusional fluorouracil as first-line chemotherapy in patients with advanced colorectal cancer. J.Clin.Oncol. 17(3):907-913, 1999

Vanhoefer U, Müller MR, Hilger RA, Lindtner B, Klaassen U, Schleucher N, Rustum YM, Seeber S, Harstrick A. Reversal of MDR1-associated resistance to topotecan by PAK-200S, a new dihydropyridine analogue, in human cancer cell lines, Br. J.Cancer 81(8):1304-1310, 1999

Yin MB, Guo B, Panadero A, Frank C, Wrzosek C, Slocum HK, Rustum YM. Cycline E-Cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor, Tomudex. Exptl. Cell Research 247:189-199, 1999

Yin MB, Toth K, Cao S, Guo B, Frank C, Slocum HK, Rustum YM. Involvement of Cyclin D1-Cdk5 overpexpression and MCM3 cleavage in Bax-associated spontaneous apoptosis and differentiation in an A253 human head and neck carcinoma xenograft model. Intl. J. of Cancer 83(3):341-348, 1999

Zangani D, Darcy KM, Masso-Welch PA, Bellamy ES, Desole MS, Ip MM. Multiple differentiation pathways of mammary stromal cells in vitro: acquisition of a fibroblast, adipocyte or endothelial phenotype is dependent on hormonal and extracellular matrix stimulation. Differentiation 64: 91-101, 1999

Zangani D, Darcy KM, Shoemaker S, Ip M. Adipocyte-epithelial interactions regulate the in vitro development of normal mammary epithelial cells. Experimental Cell Research 247:399-409, 1999