Publications and Patents: Year 2003

Molecular and Cellular Biology

Aalinkeel RK, Nair MPN, Sufrin G, Mahajan SD, Chadha KC, Schwartz, SA. Antisense inhibition of the cyclo-oxygenase-2 gene modulates the expression of pro-angiogenic molecules in prostate cancer cell lines. J Urol 169:220, 2003.

Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau J-F, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Demant P, Doerge RW, Elliott RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu W, Himmelbauer H, Hitzemann R, Hsu H-C, Hunter K, Iraqi FA, Jansen RC, Johnson TE, Jones BC, Campervan G, Lambert F, Lu L, Manly KF, Matthews DB, Medrano JEFF, Meridian M, Mittleman G, Mock BA, Mogul JS, Montagutelli X, Morahan JG, Mountz JD, Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang H-G, Zou F. The nature and identification of quantitative trait loci: a community’s view. Nat Rev Genet 4:911-916, 2003.

Ambrus JL Sr, Dembinski W, Ambrus JL Jr, Sykes DE, Akhter S, Kulaylat MN, Islam A, Chadha KC. Free Interferon -alpha/beta receptors in the circulation of patients with adenocarcinomas. Cancer 98:2730-2733, 2003.

Appenheimer MM, Huang R-Y, Chandrasekaran EV, Dalziel M, Hu Y, Soloway PD, Wuensch SA, Matta KL, Lau JTY. Biologic contribution of P1 promoter mediated expression of ST6Gal I sialyltransferase. Glycobiology 13:591-600, 2003.

Arredouani M, Matthijs P, Van Hoeyveld E, Kasran A, Baumann H, Ceuppens JL, Stevens E. Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release. Immunology 108:144-151, 2003.

Baumann H, Kunapuli P, Tracy E, Cowell JK. The oncogenic fusion protein tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable to interleukin‑6 cytokine receptors. J Biol Chem 278:16198-16208, 2003.

Benekli M, Baer MR, Baumann H, Wetzler W. Signal transducer and activator of transcription proteins in leukemias. Blood 101:2940-2954, 2003.

Bindukumar B, Schwartz SA, Aalinkeel R, Nair MPN, Cherrin C, Chadha KC. Prostate-specific antigen (PSA) regulates production and gene expression of growth factors involved in angiogenesis. 3^rd Annual Buffalo Conference on Immunology and the Boris Albini Award. Abstract, 2003.

Blanchard F, Tracy E, Smith J, Chattopadhyay S, Wang Y, Held WA, Baumann H. DNA methylation controls the responsiveness of hepatoma cells to leukemia inhibitory factor. Hepatology 38:1516-1528, 2003.

Blank RD, Baldini TH, Kaufman M, Bailey S, Gupta R, Yershov Y, Boskey AL, Coppersmith SN, Demant P, Paschalis EP. Spectroscopically determined collagen Pyr/deH-DHLNL cross-link ratio and crystallinity indices differ markedly in recombinant congenic mice with divergent calculated bone tissue strength. Connect Tissue Res 44:134-142, 2003.

Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res 13:1273-1289, 2003.

Chadha KC, Schwartz SA, Nair MPN, Demeter LR, Hewitt RG. Serum interferon inhibitor declines in patients with HIV-1 infection after a change in antiretroviral therapy. Immunol Invest 32:299-312, 2003.

Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW. Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatics 1:343-358, 2003.

Chiang PW, Oiso N, Gautam R, Swank RT, Spritz RA. The Hermansky-Pudlak syndrome 1 (HPS1) and HPS4 proteins are components of two complexes, BLOC-3 and BLOC-4, involved in the biogenesis of lysosome-related organelles. J Biol Chem 278:20332-20337, 2003.

Czarnomska A, Krysiak E, Piskorowska J, Sitarz M, Pysniak K, Pilcik T, Demant P. Opposite patterns of modifier effects on tumors of intestine and mammary gland in Apc^Min mice. Cancer Res 63:4533-4537, 2003.

Demant P. Cancer susceptibility in the mouse – genetics, biology, and implications for human cancer. Nature Reviews Genetics 4:721-734, 2003.

Gollnick SO, Evans SS, Baumann H, Owczarczak B, Maier P, Vaughan L, Wang WC, Unger E, Henderson BW. Role of cytokines in photodynamic therapy-induced local and systemic inflammation. Br J Cancer 88:1772-1779, 2003.

Hochepied T, Berger FG, Baumann H, Libert C. alpha(1)-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Rev 14:25-34, 2003.

Lau JTY, Nasirikenari M, Ostberg JR, Appenheimer, MM. Biologic contribution of ST6Gal I sialyltransferase in the early inflammatory response. Glycobiology 13:abstract 24, 2003.

Li W, Zhang Q, Oiso N, Novak EK, Gautam R, O’Brien EP, Blake DJ, Spritz RA, Copeland NG, Jenkins NA, Amato D, Roe BA, Dell’Angelica EC, Elliott RW, Mishra V, Kingsmore SF, Swank RT. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutations in dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet 35:84-89, 2003.

Lyerla TA, Rusiniak ME, Borchers M, Jahreis G, Tan J, Ohtake P, Novak E, Swank RT. Aberrant lung structure, composition and function in a murine model of Hermansky-Pudlak syndrome. Am J Physiol 285:L643-653, 2003.

Matsuyama T, Kimura MT, Koike K, Abe T, Nakao T, Asami T, Ebisuzaki T, Held WA, Yoshida S, Nagase H. Global methylation screening in the Arabidopsis thaliana and Mus musculus genome: applications of virtual image Restriction Landmark Genomic Scanning (Vi-RLGS). Nucleic Acids Res 31:4490-4496, 2003.

Pan L, Glenn ST, Jones CA, Gronostajski RM, Gross KW. Regulation of mouse renin enhancer activity by nuclear factor I Sp1/Sp3. Biochim Biophys Acta 1625:280-290, 2003.

Rosen GD, La Porte NT, Diechtiareff B, Pung CJ, Nissanov J, Gustafson C, Bertrand L, Gefen S, Fan Y, Tretiak OJ, Manly KF, Park MR, Williams AG, Connolly MT, Capra JA, Williams RW. Informatics center for mouse genomics: the dissection of complex traits of the nervous system. Neuroinformatics 1:327-342, 2003.

Ruivenkamp CAL, Csikos T, Klous AM, van Wezel T, Demant P. Five new mouse susceptibility to colon cancer loci, Scc11-Scc15. Oncogene 22:7258-7260, 2003.

Ruivenkamp C, Hermsen M, Postma C, Klous A, Baak J, Meijer G, Demant P. LOH of PTPRJ occurs early in colorectal cancer. Oncogene 22:3472-3474, 2003.

Ryan MJ, Liu B, Herbowy MT, Gross KW, Hajduczok G. Intercellular communication between renin expressing As4.1 cells, endothelial cells and smooth muscle cells. Life Sci 72:1289-1301, 2003.

Suzuki T, Oiso N, Gautam R, Novak EK, Panthier J, Suprabha PG, Vida T, Swank RT, Spritz RA. The mouse organellar biogenesis mutant buff (bf) results from a mutation in Vps33a, a homologue of yeast VPS33 and Drosophila carnation (car). Proc Natl Acad Sci USA 100:1146-1150, 2003.

Tiwari S, Italiano JE, Barral DC, Mules EH, Novak, E, Swank RT, Seabra MC, Shivdasani RA. Rab27b in NF-E2-dependent pathways of platelet formation. Blood 102:3970-3979, 2003.

Tripodis N, Demant P. Genetic analysis of three-dimensional shape of mouse lung tumours reveals eight lung tumour shape determining (Ltsd) loci, that are associated with tumour heterogeneity and symmetry. Cancer Res 63(1):125-131, 2003.

Vladimirov V, Badalová J, Svobodová M, Havelková H, Hart AAM, Blazkova H, Demant P, Lipoldová M. Different genetic control of cutaneous and visceral disease after Leishmania major infection in mouse. Infec Immun 71:2041-2046, 2003.

Wang J, Williams RW, Manly KF. WebQTL: Web-based complex trait analysis. Neuroinformatics 1:299-308, 2003.

Wenner CE, Yan S. Biphasic role of transforming growth factor beta in signal transduction and crosstalk. J Cell Physiol 196:42-50, 2003.

Wong T-W, Tracy E, Oseroff AR, Baumann H. Photodynamic therapy mediates immediate loss of cellular responsiveness to cytokines and growth factors. Cancer Res 63:3812-3818, 2003.

Young JE, Vogt T, Gross KW, Khani SC. A short highly active enhancer/promoter region upstream of the human rhodopsin kinase gene. Invest Ophthalmol Vis Sci 44:4076-4085, 2003.

Zhang Q, Zhao B, Li W, Oiso N, Novak EK, Rusiniak ME, Gautam R, Chintala S, O’Brien EP, Zhang Y, Roe BA, Elliott RW, Eicher E, Liang P, Kratz C, Legius E, Spritz RA, O’Sullivan TN, Copeland NG, Jenkins NA, Swank RT. Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6. Nat Genet 33:145-153, 2003.